Effect of cellulose acetate/cellulose triacetate ratio on reverse osmosis blend membrane performance

Surface functionalization and modification including the grafting process are effective approaches to improve and enhance the reverse osmosis (RO) membrane performance. This work is aimed to synthesize grafted/crosslinked cellulose acetate (CA)/cellulose triacetate (CTA) blend RO membranes using N-isopropylacrylamide (N-IPAAm) as a monomer and N,N-methylene bisacrylamide (MBAAm) as a crosslinker. The morphology of these membranes was analyzed by scanning electron microscopy and their surface roughness was characterized by atomic force microscopy. The performance of these membranes was evaluated through measuring two major parameters of salt rejection and water flux using RO unit at variable operating pressures. It was noted that the surface average roughness obviously decreased from 148 nm for the pure CA/CTA blend membrane with 2.5% CTA to 110 nm and 87 nm for the grafted N-IPAAm and grafted/crosslinked N-IPAAM/MBAAm/CA/CTA-RO membranes, respectively. Moreover, the contact angle decreased from 51.98° to 47.6° and 43.8° after the grafting and crosslinking process. The salt rejection of the grafted CA/CTA-RO membrane by 0.1% N-IPAAm produced the highest value of 98.12% and the water flux was 3.29 L/m²h at 10 bar.     

In vitro evaluation and in vivo performance of lyophilized gliclazide

Enhancement of the dissolution rate of the poorly water-soluble hypoglycemic agent, gliclazide, by the aid of lyophilization was investigated. Mannitol, sodium lauryl sulfate (SLS) and polyvinyl pyrrolidone (PVP-k-30) were employed in different weight ratios (43%, 56% and 64% w/w, respectively) as water-soluble excipients in the formulation. Lyophilized systems were found to exhibit extremely higher in vitro dissolution rate compared to the unprocessed drug powder. Solid state characterization of the lyophilized systems using X-ray powder diffraction, Fourier transform infrared spectroscopy and differential scanning calorimetry techniques revealed that dissolution enhancement was attributable to transformation of gliclazide from the crystalline to an amorphous state in the solid dispersion formed during the lyophilization process. The gastrointestinal absorption and hypoglycemic effect of the lyophilized gliclazide/SLS system were investigated following oral administration to Albino rabbits. C_max and area under the plasma concentration–time curve of gliclazide (AUC_0–12) after administration of the lyophilized formulations were significantly higher than those obtained after administration of the unprocessed gliclazide.     

National survey of blindness and low vision in Lebanon

Here we report a case that presented with sudden onset of neurological symptoms and was treated with ganciclovir. Polymerase chain reaction analysis for human herpes virus-6 (HHV-6) from his cerebrospinal fluid was later found to be positive. He subsequently recovered with minimal residual neurological symptoms. Encephalitis secondary to this virus may be more common than previously thought in patients undergoing bone marrow transplantation. This condition should be considered in the differential diagnosis of sudden onset neurological symptoms after bone marrow transplantation.     

Computation of the stability radius of a Schur polynomial: an orthogonal projection approach

The robust Schur stability of a polynomial with uncertain coefficients will be investigated. A formula for the stability radius of a Schur polynomial is established. The result is the counterpart of [1] for linear discrete-time systems     

Theoretical analysis of heat transfer in laminar pulsating flow

Pulsation effect on heat transfer in laminar incompressible flow, which led to contradictory results in previous studies, is theoretically investigated in this work starting from basic principles in an attempt to eliminate existing confusion at various levels. First, the analytical solution of the fully developed thermal and hydraulic profiles under constant wall heat flux is obtained. It eliminates the confusion resulting from a previously published erroneous solution. The physical implications of the solution are discussed. Also, a new time average heat transfer coefficient for pulsating flow is carefully defined such as to produce results that are both useful from the engineering point of view, and compliant with the energy balance. This rationally derived average is compared with intuitive averages used in the literature. New results are numerically obtained for the thermally developing region with a fully developed velocity profile. Different types of thermal boundary conditions are considered, including the effect of wall thermal inertia. The effects of Reynold and Prandtl numbers, as well as pulsation amplitude and frequency on heat transfer are investigated. The mechanism by which pulsation affects the developing region, by creating damped oscillations along the tube length of the time average Nusselt number, is explained.     

Effects of cocaine on dopamine receptor gene expression: a study in the postmortem human brain

The effects of chronic cocaine exposure on dopamine D1 and D2 receptor gene expression in the human brain were studied in postmortem samples from chronic cocaine abusing and matched control subjects. Using in situ hybridization of receptor autoradiography to examine messenger ribonucleic acid (RNA) and binding sites, respectively, neither D1 nor D2 receptor expression was found to be changed in the nucleus accumbens, caudate, putamen, or substantia nigra of the cocaine-exposed subjects. Although chronic cocaine exposure can produce alterations in dopaminergic neurotransmission, sustained compensatory changes in dopamine receptor expression do not appear to occur in the human.     

Thermal and hydraulic performance of a modified two-stage evaporative cooler

The thermal and hydraulic performance of a modified two-stage evaporative cooler is evaluated. Variables considered are the mode of operation, packing thickness, mass flow rate of the water flowing to the precooler, and the mass flux of water flowing over the packing media. The effectiveness of the system increased with the increase of the mass flow rate of water flowing to the precooler, decreasing the mass flux of water flowing to the packing, and with the increase of the packing thickness. The effectiveness of the system with structured packing was higher than that with sheathy leaf base or natural fiber packing.The air-side pressure drop per unit length in the direction of air flow was nearly constant when the structured packing was used. For the sheathy leaf and natural fiber packings, the air pressure drop increased at a uniform rate as the mass flux of water flowing over the packing increased. The air pressure drop was lowest for the setup with the structured packing.