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Deletion of low molecular weight protein tyrosine phosphatase (Acp1) protects against stress‐induced cardiomyopathy 下载免费PDF全文
Fallou Wade Pearl Quijada Kamar Mohamed Adib Al‐Haffar Salma Mahmoud Awad Muhammad Kunhi Haruhiro Toko Qussay Marashly Karim Belhaj Israa Zahid Falah Al‐Mohanna Stephanie M Stanford Roberto Alvarez Yingge Liu Dilek Colak Maria C Jordan Kenneth P Roos Abdullah Assiri Waleed Al‐Habeeb Mark Sussman Nunzio Bottini Coralie Poizat 《The Journal of pathology》2015,237(4):482-494
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Control of histone H3 phosphorylation by CaMKIIδ in response to haemodynamic cardiac stress 下载免费PDF全文
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Khattab Mohamed Fawzy Kannan Tareq M. A. Morsi Ahmed Al-Sabbagh Qussay Hadidi Fadi Al-Sabbagh Mohammed Qussay M.Taha Muzahem Bourghli Anouar Obeid Ibrahim 《European spine journal》2020,29(8):1806-1812
European Spine Journal - The outbreak of COVID-19 erupted in December 2019 in Wuhan, China. In a few weeks, it progressed rapidly into a global pandemic which resulted in an overwhelming burden on... 相似文献
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Cytokine polymorphisms in men with chronic prostatitis/chronic pelvic pain syndrome: association with diagnosis and treatment response 总被引:18,自引:0,他引:18
PURPOSE: The chronic pelvic pain syndrome is a common disorder of unknown etiology. Elevated cytokines in prostate fluid and semen are frequent findings. We studied genetic polymorphisms that can alter cytokine gene expression in men with the chronic pelvic pain syndrome. MATERIALS AND METHODS: Genomic DNA was extracted from blood from 36 men with the chronic pelvic pain syndrome. Reversed sequence specific oligonucleotide probing was used to genotype the polymorphisms for cytokine promoter sites, namely tumor necrosis factor (TNF)-alpha 308, transforming growth factor (TGF)-beta 25, TGF-beta 10, interleukin (IL)-10 1082 and IL-6 174. Genotype frequencies were compared with 252 controls as well as among groups of patients with the chronic pelvic pain syndrome according to diagnostic category and treatment response. RESULTS: There were no differences in men with the chronic pelvic pain syndrome and control patients in the frequency of TNF-alpha, TGF-beta or IL-6 alleles, although those with the chronic pelvic pain syndrome were more likely to express the genotype associated with low IL-10 production (30.6% versus 12.1%, p = 0.007). When comparing National Institutes of Health diagnoses, category IIIa patients were more likely to have the low TNF-alpha genotype (categories II, IIIa and IIIb 33%, 100% and 18%, respectively, p = 0.04). All 11 of the 28 patients treated with the anti-inflammatory quercetin in whom treatment failed had the low TNF-alpha genotype versus 29.4% of those in whom treatment succeeded (p = 0.0003). Similarly men with quercetin treatment failure were much less likely to have the low IL-10 genotype than those with treatment success (9.1% versus 47.1%, p = 0.04). CONCLUSIONS: Patients with the chronic pelvic pain syndrome are more likely to have a low IL-10 producing genotype, suggesting autoimmunity as a potential etiology. Anti-inflammatory phytotherapy failure was associated with low TNF-alpha and high IL-10 phenotypes, which may help define a subset of patients with the chronic pelvic pain syndrome without an inflammatory etiology. 相似文献
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Qussay Marashly MD Iosif Taleb MD Christos P. Kyriakopoulos MD Elizabeth Dranow PhD Tara L. Jones MD PharmD Anwar Tandar MD Sean D. Overton MD Joseph E. Tonna MD MS Kathleen Stoddard RN Omar Wever-Pinzon MD Line Kemeyou MD Antigone G. Koliopoulou MD Kevin S. Shah MD Kimiya Nourian BS MS Tyler J. Richins BS Tyson S. Burnham BS Frederick G. Welt MD Stephen H. McKellar MD MSc Jose Nativi-Nicolau MD Stavros G. Drakos MD PhD 《Catheterization and cardiovascular interventions》2021,98(7):1275-1284
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