Synthesis of amino-cosubstituted polyorganophosphazenes and fabrication of their nanoparticles for anticancer drug delivery

The development of safe drug carriers is cardinal in cancer therapy, which can target the cancer cells and release the loaded drug on-demand without damaging the healthy cells of the body. In our work, we synthesized three different biodegradable polymers, poly[(ethyl aminobezoate) (ethyl glycinato) phosphazenes] (PABGPs), in different mole ratio of side groups. The successful synthesis of these PABGPs was confirmed by ¹H NMR, ³¹P NMR, FT-IR, and gel permeation chromatography. These PABGPs were fabricated into drug (camptothecin, CPT, a hydrophobic anticancer drug) loaded nanoparticles. These drug-loaded nanoparticles showed good drug release behaviors under normal physiological conditions (pH 7.4 and temperature 37°C). These PABGPs-based nanoparticles may find their application as effective drug carriers for cancer therapy.     

Synthesis of Ferrocene-Based Hyperbranched Polyether and Its Catalytic Performance for Thermal Decomposition of Ammonium Perchlorate

A series of ferrocene-based hyperbranched polyethers (HBPE-Fc) with different ferrocene content were synthesized by esterification of ferrocenecarbonyl chloride and hyperbranched polyether (HBPE). ¹H NMR and FT-IR were used to confirm the structure of HBPE and HBPE-Fc. GPC was used to calculate the molecular weights. The catalytic performance of the synthesized HBPE-Fc for thermal decomposition of ammonium perchlorate (AP) was investigated by TG and DTG techniques. The results showed that HBPE-Fc exhibited good catalytic activity on the thermal decomposition of AP. The influence factors on catalytic performances, such as substitution degree of ferrocene and mass ratio of AP/HBPE-Fc were discussed as well.     

Studies on Preparation and Hydrogen Storage Properties of Dual-Metal Ferrocenyl Coordination Polymer Microspheres

A series of dual-metal ferrocenyl coordination polymer microspheres (M₁M₂-CPMs, M₁M₂ = CoMn, CoCu, MnCu) were synthesized by the reaction of 1,1′-ferrocene dicarboxylic acid with mixed metal salts via solvothermal method. From SEM and TEM images, it was found that all the as-synthesized coordination polymers showed microspheres structures. The products were also characterized by X-ray photoelectron spectroscopy (XPS), fourier transform infrared (FT-IR), powder X-ray diffraction (PXRD) and thermogravimetric analysis (TGA). The M₁M₂-CPMs showed good thermostability and remained stable up to 250 °C. These M₁M₂-CPMs exhibited hydrogen uptake capacity. More interestingly, through the comparison among three microspheres we found that the M₁M₂-CPMs with hollow structures showed better hydrogen uptake.