排序方式: 共有15条查询结果,搜索用时 27 毫秒
1.
C. Vijaya Kumar Reddy D. Sreeramulu M. Raghunath 《Food research international (Ottawa, Ont.)》2010,43(1):285-288
Epidemiological studies from other parts of the world indicate that increased consumption of fruits and vegetables are associated with lower risk of chronic degenerative diseases. Fruits are an important component of Indian diets. Studies indicate that fruits and vegetables are rich sources of phenolic compounds and antioxidant activity (AOA). Present study was taken up to determine the AOA and phenolic content of fresh and dry fruits commonly consumed in India by two different (radical scavenging) methods and relate it to their total phenolic content (TPC) for the first time. Fourteen commonly consumed fresh fruits and ten dry fruits were studied. AOA and TPC contents of both fresh and dry fruits showed marked variation. Correlation analysis between the TPC and AOA as assessed by the two methods showed that phenolics may contribute maximally to the ABTS (r = 0.84) and to lesser extent to DPPH (r = 0.77) in fresh fruits, where as in dry fruits they correlated well to DPPH activity (r = 0.97) and to a lesser extent to FRAP (r = 0.87). In general, the results indicate that majority of the fresh and dry fruits studied are rich in phenolic antioxidants with potent free radical scavenging activity imply their importance to human health. 相似文献
2.
In this paper, modes I and II crack tip fields in polycrystalline plastic solids are studied under plane strain, small scale yielding conditions. Two different initial textures of an Al-Mg alloy, viz., continuous cast AA5754 sheets in the recrystallized and cold rolled conditions, are considered. The former is nearly-isotropic, while the latter displays distinct anisotropy. Finite element simulations are performed by employing crystal plasticity constitutive equations along with a Taylor-type homogenization as well as by using the Hill quadratic yield theory. It is found that significant texture evolution occurs close to the notch tip which profoundly influences the stress and plastic strain distributions. Also, the cold rolling texture gives rise to higher magnitude of plastic strain near the tip. 相似文献
3.
Dr. Barbara Wienen‐Schmidt Tobias Wulsdorf Dr. Hendrik R. A. Jonker Dr. Krishna Saxena Dr. Denis Kudlinzki Verena Linhard Dr. Sridhar Sreeramulu Prof. Dr. Andreas Heine Prof. Dr. Harald Schwalbe Prof. Dr. Gerhard Klebe 《ChemMedChem》2018,13(18):1988-1996
A ligand‐binding study is presented focusing on thermodynamics of fragment expansion. The binding of four compounds with increasing molecular weight to protein kinase A (PKA) was analyzed. The ligands display affinities between low‐micromolar to nanomolar potency despite their low molecular weight. Binding free energies were measured by isothermal titration calorimetry, revealing a trend toward more entropic and less enthalpic binding with increase in molecular weight. All protein–ligand complexes were analyzed by crystallography and solution NMR spectroscopy. Crystal structures and solution NMR data are highly consistent, and no major differences in complex dynamics across the series are observed that would explain the differences in the thermodynamic profiles. Instead, the thermodynamic trends result either from differences in the solvation patterns of the conformationally more flexible ligand in aqueous solution prior to protein binding as molecular dynamics simulations suggest, or from local shifts of the water structure in the ligand‐bound state. Our data thus provide evidence that changes in the solvation pattern constitute an important parameter for the understanding of thermodynamic data in protein–ligand complex formation. 相似文献
4.
M. Madhusudhana Reddy G. Ramanjaneya Reddy K. Chennakesavulu E. Sundaravadivel S. S. Prasath A. M. Rabel J. Sreeramulu 《Journal of Porous Materials》2017,24(1):149-156
The present work describes the synthesis of multiwall carbon nanotubes (CNT), zinc oxide (ZnO) and their photocatalytic evolutions. Nickel doped fumed SiO2 used as substrate for the synthesis of CNT by in chemical vapour deposition method. In-situ synthesis of ZnO:CNT composites was achieved in alkaline ethanolic medium with zinc chloride and CNT. The prepared composites were investigated by the Fourier Transform Infrared spectroscopy, confocal Raman spectroscopy, diffuse reflectance UV–visible spectrophotometer (DRS), X-ray diffraction, X-ray Photoelectron Spectroscopy (XPS), Brunaur–Emmett–Teller surface area and field emission scanning/transmission electron microscopy. The composites were employed in the degradation methylene blue and Reactive red-198 under visible light irradiation. The photocatalytic activity was determined by the spectrophotometric technique. The percentage of degradation was more for ZnO:CNT composites and shows higher capacitance, when compared to that of ZnO and CNTs. The recovered and reused catalysts catalytic activity was compared with that of fresh catalyst. 相似文献
5.
6.
The components involved in the respiratory system of the euryarcheon Halobacterium salinarum were investigated by spectroscopic and polarographic techniques. Previous results about the cytochrome composition could be verified. However, under low oxygen tension, the expression of a d-type cytochrome was detected. Membranes exerted an NADH- and succinatecytochrome-c oxidoreductase as well as an NADH and succinate oxidase activity. These activities could be blocked by the following inhibitors: 7-jodocarboxylic acid, giving evidence for the presence of a type II NADH dehydrogenase, antimycin A, and myxothiazol, indicating the presence of a complex III analog, and the typical succinate dehydrogenase (SDH) and terminal oxidase inhibitors. Complex I inhibitors like rotenone and annonine were inactive, clearly excluding the presence of a coupled NADH dehydrogenase. In addition, no [Fe-S] resonances in the region of the NADH dehydrogenase (NDH) clusters could be observed after NADH addition. One of the terminal oxidases could be shown to act as a cytochrome-c oxidase with a Km value of 37 microM and an activation energy of 23.7 kJ/mol. The relative molecular mass of the endogenous c-type cytochrome could be determined as 14.1 kD. The complex III analog could be enriched after detergent extraction with Triton X-100 and hydroxylapatite (HTP) chromatography. The partially purified complex contained a Rieske iron-sulfur cluster, b- and c-type cytochromes, and was catalytically active in the decylubiquinone-cytochrome-c oxidoreductase assay. 相似文献
7.
Epidemiological evidence suggests that consumption of vegetables can prevent degenerative diseases caused by oxidative stress. Considering scanty data available on antioxidant activity (AOA) of roots, tubers and vegetables commonly consumed in India, the objective of the present study was to assess their AOA and relate it to their total phenolic content. AOA was assessed in vegetables (n = 19) and roots/tubers (n = 10) by DPPH (2,2′-diphenyl-1-picryl hydrazyl) scavenging activity and FRAP (ferric reducing antioxidant power) methods and the total phenolic content (TPC) using Folin–Ciocalteu reagent. Although AOA as well as TPC showed wide variation among roots, tubers and vegetables studied. AOA (both DPPH and FRAP) was significantly correlated with TPC among all the foods studied, with the correlation coefficient (r) values being 0.76 and 0.85 (p < 0.01) respectively with FRAP and DPPH activity among roots and tubers while among the vegetables studied, the corresponding values were 0.85 and 0.79 (p < 0.01) respectively. The results suggest that phenolic compounds may be significant contributors to the AOA of the vegetables, roots and tubers studied. 相似文献
8.
D Sreeramulu KM Nair SS Qadri KV Rao B Sivakumar 《Canadian Metallurgical Quarterly》1997,41(2):126-136
Different modes of iron depletion and repletion were studied in monkeys to understand the sequential changes in and the relative importance of different biochemical indicators of iron status. Six control monkeys were divided into two groups, one was fed an iron-deficient diet (group 1) and the other underwent phlebotomy in addition to receiving an iron-deficient diet (group 2). Previously iron-depleted monkeys were subdivided into 4 groups of 3 animals each. While one group was continued on the iron-deficient diet (group 3), the second group received parenteral iron (group 4), the third group (group 5) received a sufficient-iron-containing diet, and the fourth group was fed 50% of the iron requirement. All indicators of iron status like hemoglobin (Hb), erythrocyte protoporphyrin (EPP), serum transferrin saturation and serum ferritin were monitored periodically, in addition to liver and bone marrow iron. all the indicators except serum ferritin and liver iron showed a decrease in group 2. On the other hand, animals receiving parenteral iron (group 4) showed an increase in all the parameters except serum ferritin. The dietary supplementation produced an increase in Hb and a decrease in EPP only (groups 5 and 6). There was a significant positive correlation between changes in bone marrow iron and Hb concentration depending on the severity of depletion and repletion. Both serum ferritin and liver iron did not respond to changes in dietary iron. Another parameter which responded to repletion was EPP. Serum ferritin and liver iron did not respond to changes in dietary iron or was not sensitive to subclinical iron deficiency. The results indicate that change in Hb is more sensitive to detect the deficiency of iron. It was also observed that different parameters respond variably under different modes of depletion and repletion. 相似文献
9.
Optical,electrical, and electrochemical properties of graphene based water soluble polyaniline composites 下载免费PDF全文
Venkanna Meriga Sreeramulu Valligatla Sivaprakash Sundaresan Caroline Cahill Vinod R. Dhanak Amit K. Chakraborty 《应用聚合物科学杂志》2015,132(45)
Polyaniline (PANI) is one of the most common polymers known for its conducting properties. However, poor water solubility limits its applications. In this work, PANI has been functionalized with sulfonic acid groups to produce sulfonated PANI (SPANI) offering excellent solubility in water. To compensate for the decrease of electrical conductivity due to functionalization, SPANI was combined with reduced graphene oxide (RGO) to form SPANI/RGO composites with interesting optical, thermal, and electrical properties. The composites have been characterized using X‐ray diffraction (XRD), field emission scanning electron microscopy, UV–vis absorption spectroscopy, Raman spectroscopy, Fourier‐transform infrared spectroscopy, X‐ray photoelectron spectroscopy, thermogravimetric analysis, cyclic voltammetry, and four probe electrical conductivity measurement. The SPANI/RGO composites show increased thermal stability, reduced optical band gap and improved electrochemical properties compared with the pure polymer. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132, 42766. 相似文献
10.
Oliver Binas Vanessa de Jesus Tom Landgraf Albrecht Eduard Völklein Jason Martins Daniel Hymon Jasleen Kaur Bains Hannes Berg Thomas Biedenbänder Dr. Boris Fürtig Dr. Santosh Lakshmi Gande Dr. Anna Niesteruk Andreas Oxenfarth Dr. Nusrat Shahin Qureshi Tatjana Schamber Robbin Schnieders Alix Tröster Dr. Anna Wacker Dr. Julia Wirmer-Bartoschek Maria Alexandra Wirtz Martin Elke Stirnal Dr. Kamal Azzaoui Dr. Christian Richter Dr. Sridhar Sreeramulu Dr. Marcel Jules José Blommers Prof. Dr. Harald Schwalbe 《Chembiochem : a European journal of chemical biology》2021,22(2):423-433
We report here the nuclear magnetic resonance 19F screening of 14 RNA targets with different secondary and tertiary structure to systematically assess the druggability of RNAs. Our RNA targets include representative bacterial riboswitches that naturally bind with nanomolar affinity and high specificity to cellular metabolites of low molecular weight. Based on counter-screens against five DNAs and five proteins, we can show that RNA can be specifically targeted. To demonstrate the quality of the initial fragment library that has been designed for easy follow-up chemistry, we further show how to increase binding affinity from an initial fragment hit by chemistry that links the identified fragment to the intercalator acridine. Thus, we achieve low-micromolar binding affinity without losing binding specificity between two different terminator structures. 相似文献