A new supervised classification algorithm in artificial immune systems with its application to carotid artery Doppler signals to diagnose atherosclerosis

Because of its self-regulating nature, immune system has been an inspiration source for usually unsupervised learning methods in classification applications of Artificial Immune Systems (AIS). But classification with supervision can bring some advantages to AIS like other classification systems. Indeed, there have been some studies, which have obtained reasonable results and include supervision in this branch of AIS. In this study, we have proposed a new supervised AIS named as Supervised Affinity Maturation Algorithm (SAMA) and have presented its performance results through applying it to diagnose atherosclerosis using carotid artery Doppler signals as a real-world medical classification problem. We have employed the maximum envelope of the carotid artery Doppler sonograms derived from Autoregressive (AR) method as an input of proposed classification system and reached a maximum average classification accuracy of 98.93% with 10-fold cross-validation method used in training-test portioning. To evaluate this result, comparison was done with Artificial Neural Networks and Decision Trees. Our system was found to be comparable with those systems, which are used effectively in literature with respect to classification accuracy and classification time. Effects of system's parameters were also analyzed in performance evaluation applications. With this study and other possible contributions to AIS, classification algorithms with effective performances can be developed and potential of AIS in classification can be further revealed.     

Effect of gravity on InGaSb crystal growth

The effect of gravity on dissolution of GaSb in InSb melt and growth of InGaSb was experimentally investigated. Experiments were carried out in a GaSb(seed)/InSb/GaSb(feed) sandwich system under an imposed temperature gradient. In the experiments, the GaSb feed crystal dissolved into the InSb melt to supply the required GaSb component for the growth of In_0.1Ga_0.9Sb crystal. Two parameters were considered: (1) the inclination angle (θ) of the sample for gravity as 0° and 53°, and (2) the sample diameter (D) as 9 mm and 5mm. When θ was 0°, the interface was almost flat, indicating that convection was axisymmetric and stable. Whereas the interface was distorted towards gravitational direction when θ was 53°, indicating that solutal convection was dominant. The decrease of growth temperature and sample diameter reduced the distortion of interface and the dissolution amount of GaSb feed. The homogeneous crystals were grown at the initial growth stage by supplying the GaSb component during growth.     

Turned trochoidal disturbance on a liquid jet surface

This paper shows that a turned trochoidal function disturbance may lead to peripheral drops production. The resulting model is used to describe that a turned trochoidal disturbance leads to peripheral drops production on the liquid jet surface without the necessity for superimposed disturbances. The trochoid is a non-unique parametric function. Only non-unique parametric functions disturbances may lead to peripheral drops production. The trochoidal function disturbance is decomposed to Fourier series. Every Fourier element receives an amplification factor in accordance to the Rayleigh inviscid jet model. Peripheral drops are received on the jet surface. The paper shows that all trochoidal disturbance functions, prolate cycloid, cycloid and curtate cycloid have a capability of peripheral drops producing. A limited capability of peripheral drops production is introduced for the trochoidal curtate cycloid. Produced drops size are reduced for increasing the jet velocity and wave number. Smaller drops are also received by transition from the prolate cycloid to curtate cycloid disturbance.     

Misalignment tolerance analysis of free-space optical interconnects via statistical methods

System-level packaging is one of the critical issues that need to be addressed for free space optical interconnections (FSOI) to become useful in desktop systems. The performance of FSOI, e.g., in terms of system bit-error rate, is greatly affected by misalignments in the optical system. Therefore tolerancing, i.e., the ability to analyze and predict the effects of misalignments in the system, is of prime importance to system designers. We introduce an approach in which we study the effects of optical misalignments and other tolerance factors using statistical methods. We use Monte Carlo simulations, design of the experiments, and regression techniques to fit a polynomial equation that expresses the relationship between the system performance and the tolerance factors. This prediction model can be used for design, cost optimization, and quality control purposes. In addition, we perform a sensitivity analysis to determine those tolerance variables that have the greatest effect on system performance.     

A receptor-based bioassay for quantitative detection of gallium

The detection of gallium in biological samples is required due to its role in the diagnosis of tumor and for possible treatment of malignancies. However, the use of purely instrumental techniques is unsuitable for detection of low levels of gallium in biological matrixes. We have synthesized new protein conjugates based on 4-(2-pyridylazo) ligands. The conjugates were successfully employed for the detection of gallium in biological matrixes using a nonantibody-based sandwich assay format. The recovery level obtained was between 97 and 101.3 with a relative standard deviation of less than 5%. The assay resulted in a detection limit of 5 x 10(-8) M and a remarkable selectivity for gallium(III) relative to other metals investigated. The new method provided adequate accuracy for gallium applicable for animal physiology and clinical toxicology.     

Correlation of analyte structures with biosensor responses using the detection of phenolic estrogens as a model

The apparent increase in hormone-induced cancers and disorders of the reproductive tract in wildlife and humans has led to a search for an accurate and reliable method for monitoring endocrine-disrupting chemicals (EDCs). This study presents a generic approach that may allow researchers to establish screening procedures for potential EDCs by correlating the analyte structures with biosensor responses and explain possible reaction mechanisms. A simple amperometric tyrosinase-based biosensor (Tyr-CPE) has been developed for the detection of phenolic EDCs. The investigation of the enzymatic oxidation of selected phenolic estrogens was first carried out using UV-vis spectroscopy. The result was used to correlate sensor responses to enzymatic activity. Natural phytoestrogen polyphenols, including resveratrol (RES), genistein (GEN), and quercetin (QRC), were compared with synthetic estrogens, for example, bisphenol A (BPhA), nonylphenol (NPh), and diethylstilbestrol (DES). The Tyr-CPE biosensor resulted in rapid, simple, and accurate measurement of phenolic estrogens with varying degrees of sensitivity, selectivity, and response times. The sensor responses have been evaluated for the detection of binary and tertiary mixtures of EDCs and natural estrogens. The results showed that BPhA could be successfully discriminated in a composite mixture containing NPh and DES at various ratios. In the case of natural phenolic estrogens GEN, RES, and QRC, the sensor allows the determination of a total phenolic content. The sensor was also validated for the detection of BPhA in a real environmental water sample, and the results was compared with standard ASTM method 9065. Mechanistically, our results indicated that the number of OH groups, the nature and the position of aryl ring substituents, or both could affect the detection limit and the biosensor sensitivity.     

Highly conductive polymer materials based multi-walled carbon nanotubes as counter electrodes for dye-sensitized solar cells

Poly(3,4-ethylenedioxxythiophene) (PEDOT), polyaniline (PANI) and polythiophene (PTh) based multi-walled carbon nanotube (MWCNT) composites were successfully prepared using RF-rotating plasma grafting method. Morphological characterizations of composites were determined using scanning electron microscopy (SEM), which showed that conducting polymers (CPs) of PEDOT, PANI and PTh were coated on the surface of CNTs. The surface properties of the Carbon Nanotube (CNT) composites were also determined by using Infrared Spectra (FT-IR), X-ray Photon Spectra (XPS), and Scanning Electron Microscopy-Energy Dispersive X-ray Spectra (SEM-EDX) analysis. X-ray photon spectra results confirmed the formation of the composites. Composites of MWCNT were used in dye-sensitized solar cells (DSSCs) as counter electrodes and exhibited short-circuit photocurrent densities of 11.19, 10.70 and 8.54 mA/cm² for PANI/MWCNT, PTh/MWCNT and PEDOT/CNT, respectively.     

A Bound for the Order of Characteristic Set Elements of an Ordinary Prime Differential Ideal and some Applications

With respect to an elimination ordering, we give an upper bound for the order of characteristic set elements of an ordinary prime differential ideal. Using some results of complexity in the algebraic case, we show that computing characteristic sets of ordinary prime differential ideals, by change of ordering, is single exponential time. Received: January 8, 1997; revised version: May 6, 1999     

Teacher beliefs and technology integration practices: A critical relationship

Early studies indicated that teachers’ enacted beliefs, particularly in terms of classroom technology practices, often did not align with their espoused beliefs. Researchers concluded this was due, at least in part, to a variety of external barriers that prevented teachers from using technology in ways that aligned more closely with their beliefs. However, many of these barriers (access, support, etc.) have since been eliminated in the majority of schools. This multiple case-study research was designed to revisit the question, “How do the pedagogical beliefs and classroom technology practices of teachers, recognized for their technology uses, align?”     

A colloidal method for manganese oxide addition to alumina powder and investigation of properties

Various methods can be applied to introduce additives to ceramic materials. Of these methods, mechanical mixing may not always be suitable to obtain a uniform distribution of the small quantities of additive within the structure, requiring colloidal methods to be applied for the purpose. The addition of manganese oxide to alumina powder has been studied using a colloidal method. The effect of the manganese addition on alumina microstructure and the later stages of the densification behaviour was investigated, together with the hardness and mechanical strength. No evidence of secondary phase formation was detected between the manganese cation and alumina powder for up to 0.5wt% manganese addition, suggesting that manganese is in solid solution with alumina. The microstructural evidence presented suggests that small quantities of a manganese addition to alumina enhance the densification process through the formation of fast diffusion paths within the crystalline structure, similar to the effect of TiO₂ addition.