Increased Emulsion Stability for Reverse Y‐Shaped Sugar‐Based Surfactants

A series of reverse Y‐shaped surfactants containing aromatic and aliphatic linkers to combine two short hydrocarbon chains and one carbohydrate head group was prepared. Liquid crystalline behavior, air–water interfacial properties, and efficiency as an emulsifier was investigated for each reverse Y‐shaped surfactant. All reverse Y‐shaped surfactants mediated higher emulsion stabilities for water‐in‐oil compared to common typical reference surfactants, reflecting an improved ability to cope with a curvature towards water. The introduction of a benzene ring into the linker substantially increased the affinity of the surfactant for hydrophobic media, resulting in improved emulsion stability for both water‐in‐oil and oil‐in‐water.     

Nanovesicles Based on Mixtures of a Biantennary Glycolipid with Ionic Co‐Surfactants

A biantennary surfactant based on a synthetic C₁₆‐maltoside was chosen to prepare vesicles for a potential vesicular drug delivery system. The synthesis comprised of three stages: Initial synthesis of β‐d ‐maltose octaacetate was followed by glycosidation of 2‐hexyl‐decanol and final glycolipid deacetylation. Both α‐ and β‐anomers were prepared and their anomeric purity was evaluated by ¹H NMR. Owing to the low water solubility of the glycolipid, addition of ionic co‐surfactants was believed to promote the surfactant distribution, thus leading to smaller and more uniform vesicles. The assembly behavior of the surfactant systems was studied by contact penetration under an optical polarizing microscope, while interfacial properties were determined by surface tension measurements. Vesicles were prepared by injection of an ethanolic solution into bulk water and investigated by dynamic light scattering and field emission scanning electron microscopy. Contact of the surfactant mixtures with water indicated a high tendency to exhibit the lamellar phase and confirmed the expected low molecular solubility. These findings suggest a potential of the surfactant to form stable vesicles. Injection of an ethanolic surfactant solution into bulk water gave sub‐micrometer sized vesicles with a narrow size distribution. Application of ionic co‐surfactants reduced the vesicle size. In particular ～20 % of anionic SDS proved highly effective, lowering the vesicle size by nearly one decade, thus accessing nano‐sized vesicles. Encapsulation of a water‐soluble drug was achieved in a 76 ± 10 % efficiency.     

A Review on the Role of miR-149-5p in the Carcinogenesis

miR-149 is an miRNA with essential roles in carcinogenesis. This miRNA is encoded by the MIR149 gene on 2q37.3. The miR-149 hairpin produces miR-149-5p and miR-149-3p, which are the “guide” and the sister “passenger” strands, respectively. Deep sequencing experiments have shown higher prevalence of miR-149-5p compared with miR-149-3p. Notably, both oncogenic and tumor suppressive roles have been reported for miR-149-5p. In this review, we summarize the impact of miR-149-5p in the tumorigenesis and elaborate mechanisms of its involvement in this process in a variety of neoplastic conditions based on three lines of evidence, i.e., in vitro, in vivo and clinical settings.     

The Emerging Role of Non-Coding RNAs in the Regulation of Virus Replication and Resultant Cellular Pathologies

Non-coding RNAs, particularly lncRNAs and miRNAs, have recently been shown to regulate different steps in viral infections and induction of immune responses against viruses. Expressions of several host and viral lncRNAs have been found to be altered during viral infection. These lncRNAs can exert antiviral function via inhibition of viral infection or stimulation of antiviral immune response. Some other lncRNAs can promote viral replication or suppress antiviral responses. The current review summarizes the interaction between ncRNAs and herpes simplex virus, cytomegalovirus, and Epstein–Barr infections. The data presented in this review helps identify viral-related regulators and proposes novel strategies for the prevention and treatment of viral infection.     

Soil aquifer treatment using advanced primary effluent

Soil aquifer treatment (SAT) using primary effluent (PE) is an attractive option for wastewater treatment and reuse in many developing countries with no or minimal wastewater treatment. One of the main limitations of SAT of PE is rapid clogging of the infiltration basin due to high suspended solid concentrations. Some pre-treatment of PE before infiltration is likely to reduce this limitation, improve performance of SAT and help to implement this technology effectively. The effects of three pre-treatment options namely sedimentation (SED), coagulation (COAG) and horizontal roughing filtration (HRF) on SAT were analyzed by conducting laboratory-scale batch and soil column experiments. The sedimentation and coagulation pre-treatments led to less head loss development and reduction of clogging effect. The head loss development in soil column using PE + COAG and PE + SED was reduced by 85 and 72%, respectively, compared to PE alone without any pretreatment. The overall dissolved organic carbon (DOC) removal of pre-treatments and soil column collectively were 34, 44, 51 and 43.5% for PE without any pre-treatment, PE + SED, PE + COAG and PE + HRF, respectively. Coagulation pre-treatment of PE was found to be the most effective option in terms of suspended solids, DOC and nitrogen removal. Sedimentation pre-treatment of PE could be attractive where land is relatively less expensive for the construction of sedimentation basins.     

A Review on the Role of Non-Coding RNAs in the Pathogenesis of Myasthenia Gravis

Myasthenia gravis (MG) is an autoimmune condition related to autoantibodies against certain proteins in the postsynaptic membranes in the neuromuscular junction. This disorder has a multifactorial inheritance. The connection between environmental and genetic factors can be established by epigenetic factors, such as microRNAs (miRNAs) and long non-coding RNAs (lncRNAs). XLOC_003810, SNHG16, IFNG-AS1, and MALAT-1 are among the lncRNAs with a possible role in the pathoetiology of MG. Moreover, miR-150-5p, miR-155, miR-146a-5p, miR-20b, miR-21-5p, miR-126, let-7a-5p, and let-7f-5p are among miRNAs whose roles in the pathogenesis of MG has been assessed. In the current review, we summarize the impact of miRNAs and lncRNAs in the development or progression of MG.     

Development of a solar cooker in Brunei Darussalam

A program to develop, test and evaluate a solar cooker was carried out with the primary objective of its suitability as an alternative means of cooking using sun rays. Factors considered in the evaluation of the solar cooker include the maximum temperature attained, time taken to boil rice, time taken to cook a variety of Malay dishes, ease of use, portability, material cost and ease of manufacture. Initially a box type solar cooker was developed using improvised materials. The evaluation of the solar cooker based on the test results, the feasibility and possible modification in the design to improve the efficiency is discussed.     

Amide-Based Surfactants from Methyl Glucoside as Potential Emulsifiers

A series of amide-linked surfactants from methyl glucoside was synthesized and investigated for their potential use as water-in-oil emulsifiers. The synthetic concept combined a nucleophilic substitution approach with a Staudinger coupling of the intermediate azide. Both straight and Guerbet-type branched fatty acids ranging from C₈ to C₁₆ were applied. All surfactants exhibited very high Krafft temperatures, which were related to the amide linkage and exclusively formed the hexagonal H₁-phase. The Guerbet C₁₆ surfactant enabled the formation of a stable water-in-oil gel at ambient temperature, which, however, required heating to form the corresponding fluid emulsion.