Tissue-Engineered Vascular Grafts: Emerging Trends and Technologies

Vascular tissue engineering has made prodigious progress in recent years by converging multidisciplinary approaches. Latest technological advancements foster the development of next-generation tissue-engineered vascular grafts (TEVGs) for treating various vasculopathies. While traditional therapeutic methods rely on bypassing the severely damaged vessels with synthetic counterparts with no growth potential, contemporary perspectives focus on biodegradable conduits bestowing an inherent remodeling capability. This review highlights emerging innovative trends and technologies adopted to pragmatically fulfill current scientific needs while improving overall TEVG performance in pre-clinical and clinical settings. A comprehensive overview of various milestones achieved in the past few decades is first summarized, followed by an appraisal of the significant hurdles for clinical translation. The latest techniques to rationally address critical challenges, viz., intimal hyperplasia, thrombosis, constructive graft remodeling, and adequate neo-tissue formation are discussed. Finally, an update on ongoing clinical trials is provided and future perspectives required to persuade TEVGs to become a clinical reality are delineated.     

An outlook on comparison of hybrid welds of different root pass and filler pass of FCAW and GMAW with classical welds of similar root pass and filler pass

In the present study, gas metal arc welding and flux cored arc welding were applied on SA516 Gr70 carbon steel material. Two different hybrid passes were applied, wherein flux cored wire and solid wire were applied to root pass and filler pass one by one and vice versa. Besides, two more welds of similar electrode root pass and filler pass of flux cored arc welding and gas metal arc welding were acquired. The comparative analysis was carried out in terms of macrostructure and microstructure examination, tensile testing, hardness variations, and impact testing for these classical welds and hybrid welds. The results reveal that, hybrid welds lead to better impact properties relative to classical welds. Maximum angular distortion of 2.66° was reported with classical weld of gas metal arc welding with solid wire root pass and same filler pass. The maximum impact toughness of 49 J/m³ was reported for flux cored root pass and solid wire filler pass at the weld zone. Maximum tensile strength of 596 MPa was reported for hybrid weld of solid root pass and flux cored filler pass. Microstructures are reported with the presence of different acicular ferrite and grain boundary ferrite. Maximum acicular ferrite of 61% was reported with classical weld of flux cored arc welding.     

Study of Amorphous Compounds Obtained by Ball Milling in the Si–C–O System

Generally, the Si–C–O system is composed of SiO₂, SiC, and pure C as crystalline phases. In the present study, we focus on the preparation of ternary silicon oxycarbide compound. For this purpose, different mixtures of quartz, silicon, and graphite were ball milled to cover the following range of composition: (1) SiC _x O_{2(1 – x)} + excess of C; (2) SiC _x O_{2(1 – x)} stoichiometric; (3) SiC _x O_{2(1 – x)} + excess of Si. The course of the reaction is followed by X-ray diffraction, by measuring the relative intensity change of the Bragg's peaks as a function of the mechanical treatment. The Rietveld method is applied to the patterns for quantitative analysis and determination of crystallite size and microstrain. Finally, the behavior of each phase is reported across the three starting compositions examined here and the presence of silicon oxycarbide compounds induced by ball milling is assessed by [²⁹Si-MAS]NMR.     

Investigation on various welding consumables on properties of carbon steel material in gas metal arc welding under constant voltage mode

In this present work, the influence of different consumables on weld properties of carbon steel plate was studied by automatic gas metal arc welding under constant voltage mode. For all experiments, the process parameters such as welding current of 200 A, voltage of 28 V and welding speed of 200 mm/min were kept constant. The results indicate that the angular distortion remained higher for solid wire, whereas it was minimum for flux-cored wire and the lowest in metal-cored wire. Mechanical properties such as yield strength, tensile strength, elongation and joint efficiency remained high for solid wire relative to cored wire. Excellent impact toughness of the weld metal and heat-affected zone was reported for the flux-cored welds compared with solid wire and metal-cored welds.     

Influence of Friction Stir Processed Parameters on Superplasticity of Al-Zn-Mg-Cu Alloy

Friction stir processing (FSP) is a novel technique for refining the microstructure. In this study, the effect of FSP process parameters such as tool rotation, traverse speed and tool tilt on resulting grain size, microstructure and superplastic behavior of high-strength thick Al-Zn-Mg-Cu alloy is reported. The microstructure examination of the stir zone (SZ) was performed by optical as well as scanning electron microscope. Microstructure variation attributed to different process parameters is reflected in the SZ. It is observed that grain size increases with increasing tool rotation speed, and decreases with increasing traverse speed. However, tool tilt has no significant effect on grain size. Moreover, at higher tool tilt distorted grains were observed in microscopic images. The highest average value of hardness in the SZ is obtained for low heat input value corresponding to higher tool rotation and traverse speed. In this study, hardness has shown no dependency on the grain size of the SZ due to the strengthening of phase particles. Process parameter of 1500 rpm, 31.5 mm/min and 2° tool tilt (low heat input) only exhibited superplastic elongation of 225% at a superplastic condition of 400°C and 3 × 10^?4 s^?1 because of an appropriate material flow without any defect.     

Traveling Wire Electrochemical Discharge Machining (TW-ECDM) of Quartz Using Zinc Coated Brass Wire: Investigations on Material Removal Rate and Kerf Width Characteristics

Silicon - In this era, advanced non-conducting materials are gaining importance due to their superior properties. However, it is difficult to micro-machine these materials inefficiency and also...     

Influence of heat input/multiple passes and post weld heat treatment on strength/electrochemical characteristics of friction stir weld joint

The V-95 and D-19 precipitation hardened Russian aluminum alloys are widely used in the Russian aircraft industry and these alloys are not weldable by conventional fusion weld techniques. This paper intends to evaluate the effect of spindle and weld speed on joint strength characteristics of a single pass (SP) and double pass (DP) friction stir lap weld through a common heat index and to analyze the effect of retrogression and re-ageing treatment (RRA) on joint strength and corrosion characteristics. The strength characteristics were analyzed by welding and shear testing of specimens and corrosion susceptibility of joint through immersion in EXCO solution as per ASTM G34. The trials revealed that the joint strength of the welded alloy is inversely proportional to the heat index and the DP weld provided significantly higher strength than an SP weld. The heat affected zone of the joint was found most sensitized to corrosion. The RRA treatment was found to improve the strength of the joints welded with higher heat input while it slightly degraded the joint strength for low heat input welds. The corrosion characteristics of the welded joint is also significantly improved by the post weld RRA treatment.     

Barium ion leaching from barium titanate powder in water

A submicrometer-sized commercial BaTiO₃ (BT) powder was aged in water under three different conditions: pH, aging times, and pre-heat treatments of the powder. The amount of Ba²⁺ ions leaching from the BT particles was determined by the EDTA titration method. As predicted by thermodynamic calculation, the greater extent and the faster rate of Ba²⁺ leaching were found at the lower solution pH, leveling off at pH 8. The pre-heat treatments of the BT powder increased the amount of Ba²⁺ leaching when compared to the as-received one. This result was shown by the formation of soluble surface BaCO₃, which was detected using FT-IR spectroscopy. It was also shown that organic passivation agents were effective reducing the Ba²⁺ leaching but at high solution pH.