Spatial memory deficits following stimulation of hippocampal 5-HT1B receptors in the rat

The authors review the principles of reconstructive surgery for lower limb salvage after severe lower limb trauma to determine factors that have been used as decision-making criteria for limb salvage or amputation in severe lower extremity injuries and the methods of reconstruction and their outcome. The use of scoring systems and their value in acute decision making (primary amputation or limb salvage) are described. Soft-tissue reconstructive techniques, with emphasis on the use of flaps and the importance of selecting the best technique and time for the reconstruction are reviewed. Skeletal reconstructive techniques are described, including available options and currently held views on indications and use of the best contemporary methods. It is essential for the physician to make a good initial decision on the need for primary amputation or limb salvage. A multidisciplinary approach is fundamental to successful salvage.     

Improved genetic algorithm for channel allocation with channel borrowing in mobile computing

This paper exploits the potential of the Genetic Algorithm to solve the cellular resource allocation problem. When a blocked host is to be allocated to a borrowable channel, a crucial decision is which neighboring cell to choose to borrow a channel. It is an optimization problem and the genetic algorithm is efficiently applied to handle this. The Genetic Algorithm, for this particular problem, is improved by introducing a new genetic operator, named pluck, that incorporates a problem-specific knowledge in population generation and leads to a better channel utilization by reducing the average blocked hosts. The pluck operator makes the crucial decision of when and which cell to borrow with the future consideration that the borrowing should not lead the network to chaos. It makes a channel borrowing decision that minimizes the number of blocked hosts and improves the long-term performance of the network. Efficacy of the proposed method has been evaluated by experimentation.     

Interaction of nonylphenol and hepatic CYP1A in rats

Both estradiol and nonylphenol (NP) inhibited hepatic microsomal 7-ethoxyresorufin O-deethylase (EROD) activity of beta-naphthoflavone-treated rats. Enzyme kinetic analyses (Lineweaver-Burk plots) using different estradiol and NP concentrations with graded increases in the concentrations of the substrate, ethoxyresorufin, showed that the inhibition was of a competitive nature at all concentrations of estradiol or NP used. Thus, the mechanism by which NP inhibits EROD activity is similar to that of estradiol. NP, however, was much less potent than estradiol. Young rats treated in vivo with 80 mg/kg body weight of NP demonstrated a slight but significant decrease in their hepatic microsomal EROD activity and CYP1A protein as measured by western blot analysis. In addition, treatment with NP led to a decrease in the steady-state levels of hepatic CYP1A mRNA in rats, suggesting that NP acted at the pre-translational level. The competitive nature of inhibition by NP on hepatic microsomal EROD activity indirectly suggests that this compound is a possible substrate of the CYP1A enzyme. Furthermore, NP had a moderate modulating effect on the expression of CYP1A in rat liver.     

First-principles investigation of F-functionalized ZGNR/AGNR for nanoscale interconnect applications

Journal of Computational Electronics - Zigzag and armchair graphene nanoribbons (ZGNR and AGNR) have been investigated using the density functional theory (DFT) and nonequilibrium Green’s...     

Enhancement of electromechanical properties of natural rubber by adding barium titanate filler: An electro-mechanical study

Natural rubber is one of the most potential electro-active polymers for sensors, actuators, and energy harvesting applications. Enhancing the characteristic properties of polymers by reinforcing with fillers that possess multifunctional attributes have attracted considerable attention. In the present study, barium titanate reinforced natural rubber composite is prepared by using two-roll mill mixing. Afterwards, mechanical, electrical, and electromechanical properties of the composites are extensively analyzed by reinforcing different amounts of barium titanate into the matrix of natural rubber. The fabricated dielectric composite shows excellent properties such as high dielectric constant, low dielectric losses, high dielectric breakdown strength, and extreme stretchability. It is observed that as the filler loading reaches the value of 11 parts per hundred rubber (phr), maximum agglomeration of the particles occurs. Maximum stretchability and highest ratio of dielectric constant to elastic modulus are obtained at 8 phr of barium titanate fillers and at the loading, a maximum actuation strain of 11.24% is achieved. This study provides a simple, economical, and effective method for preparing enhanced mechanical, electrical, and electromechanical properties of natural rubber composites, facilitating the wide applications of dielectric materials as actuators and generators.     

Reliable before-fabrication forecasting of MEMS piezoresistive pressure sensor: mathematical modelling and numerical simulation

Microsystem Technologies - Micro-mechanical systems (MEMS) based piezoresistive pressure sensors have significant importance in several pressure sensor devices in real world, i.e., aviation, IoT...     

Cutting force and hole quality analysis in micro-drilling of CFRP

Micro-drilling in carbon fiber reinforced plastic (CFRP) composite material is challenging because this material machining is difficult due to anisotropic, abrasive and non-homogeneous properties and also downscaling of cutting process parameters affect the cutting forces and micro-drilled hole quality extensively. In this work, experimental results based statistical analysis is applied to investigate feed and cutting speed effect on cutting force components and hole quality. Analysis of variance based regression equation is used to predict cutting forces and hole quality and their trend are described by response surface methodology. Results show that roundness error and delamination factor have similar trends to those of radial forces and thrust force, respectively. Non-linear trends of cutting forces and hole quality errors are observed during downscaling of the micro-drill feed value. Optimization results show that cutting forces and hole quality errors are minimum at a feed value which is almost equal to the tool edge radius rather than at the lowest feed value. Therefore, the presented results clearly show the influences of size effects on cutting forces and hole quality parameters in micro-drilling of CFRP composite material.     

Fairness of Transitions in Diagnosability of Discrete Event Systems

Failure diagnosability has been widely studied for discrete event system (DES) models because of modeling simplicity and computational efficiency due to abstraction. In the literature it is often held that for diagnosability, such models can be used not only for systems that fall naturally in the class of DES but also for the ones traditionally treated as continuous variable dynamic systems. A class of algorithms for failure diagnosability of DES models has been successfully developed for systems where fairness is not a part of the model. These algorithms are based on detecting cycles in the normal and the failure model that look identical. However, there exist systems with all transitions fair where the diagnosability condition that hinges upon this feature renders many failures non-diagnosable although they may actually be diagnosable by transitions out of a cycle. Hence, the diagnosability conditions based on cycle detection need to be modified to hold for many real-world systems where all transitions are fair. In this work, however, it is shown by means of an example that a system may have some transitions fair and some unfair. A new failure diagnosability mechanism is proposed for DES models with both fair and unfair transitions. Time complexity for deciding diagnosability of DES models with fair and unfair transitions is analyzed and compared with the time complexities of other DES diagnosability analysis methods reported in the literature.     

Boundedness analysis of finitely recursive processes. I. Concurrentprocesses

In the finitely recursive process (FRP) model of discrete event systems (DES), concepts about processes and process operators have been introduced. An infinite set of process expressions or functions can be built recursively through function composition using a few elementary operators. Given any process realization, it is important to find out whether the process is bounded, i.e., whether it has a finite state realization. In the FRP setting this translates to the problem of finding out whether the set of post-process expressions is finite or not. In Cieslak and Varaiya (1990) it has been shown that the boundedness problem is undecidable for general FRPs. This paper investigates the decidability of the problem for subclasses of FRP. In Inan and Varaiya (1988), it was conjectured that the set of functions that can be recursively generated using the parallel composition operator and different change operators (i.e. without using the sequential composition operator) will be finite and FRPs constructed over this set of functions will naturally be bounded. In the present work a counterexample has been provided to disprove the conjecture about the finiteness of the above set of functions. However, using a suitable post-process computation procedure, it has been shown here that the FRPs, built recursively over this set of functions, are bounded     

Stress intensity factors for an interfacial crack between an orthotropic half-plane bonded to a dissimilar orthotropic layer with a punch

The plane strain problem of determining Stress Intensity Factors (SIF) for a moving interfacial Griffith crack between an elastic orthotropic half-plane and a dissimilar orthotropic layer with a moving punch situated along the boundary of the layer have been considered. The problem is reduced to the solution of three simultaneous singular integral equations with Cauchy-type singularities. Expressions for SIF for the case of a general loading are obtained. Numerical results for some particular cases are also presented graphically.