Prolonged poststrike elevation in tongue-flicking rate with rapid onset in gila monster,Heloderma suspectum: Relation to diet and foraging and implications for evolution of chemosensory searching

Experimental tests showed that poststrike elevation in tongue-flicking rate (PETF) and strike-induced chemosensory searching (SICS) in the gila monster last longer than reported for any other lizard. Based on analysis of numbers of tongue-flicks emitted in 5-min intervals, significant PETF was detected in all intervals up to and including minutes 41–45. Using 10-min intervals, PETF lasted though minutes 46–55. Two of eight individuals continued tongue-flicking throughout the 60 min after biting prey, whereas all individuals ceased tongue-flicking in a control condition after minute 35. The apparent presence of PETF lasting at least an hour in some individuals suggests that there may be important individual differences in duration of PETF. PETF and/or SICS are present in all families of autarchoglossan lizards studied except Cordylidae, the only family lacking linguallly mediated prey chemical discrimination. However, its duration is known to be greater than 2-min only in Helodermatidae and Varanidae, the living representatives of Varanoidea. That prolonged PETF and SICS are typical of snakes provides another character supporting a possible a varanoid ancestry for Serpentes. Analysis of 1-min intervals showed that PETF occurred in the first minute. A review of the literature suggests that a pause in tongue-flicking and delay of searching movements are absent in lizards and the few nonvenomous colubrid snakes tested. The delayed onset of SICS may be a specific adaptation of some viperid snakes to allow potentially dangerous prey to be rendered harmless by venom following voluntary release after envenomation and preceding further physical contact with the prey.     

Myoblast-mediated gene transfer to the joint

Several genetic and acquired pathologic conditions of the musculoskeletal system, such as arthritis and damage to ligament, cartilage, and meniscus, may be amenable to gene therapy. Even though ex vivo gene transfer with synovial cells has been shown to deliver genes encoding for anti-arthritic proteins into the rabbit knee joint, its success has been limited by a transient transgene expression. In this study, data were investigated regarding the use of muscle cells as an alternative gene-delivery vehicle to the joint in newborn rabbit and adult severe combined immunodeficiency mice. We demonstrated that myoblasts were transduced more efficiently than synovial cells with use of the same adenoviral preparation in vitro. After intra-articular injection, the engineered muscle cells adhered to several structures in the joint, including the ligament, capsule, and synovium. In addition, myoblasts fused to form many post-mitotic myotubes and myofibers at different locations of the joint of the newborn rabbit 5 days after the injection. In the knee of the adult mouse, myoblasts fused and expressed the reporter gene for at least 35 days after the injection. The presence of post-mitotic myofibers in the knee joint raises the possibility of long-term expression of the secreted protein. Currently, numerous tissues in the joint (ligament, meniscus, and cartilage) have poor intrinsic healing capacity and frequently need surgical corrections. A stable gene-delivery vehicle to the joint producing proteins that ameliorate these different musculoskeletal conditions may change the clinical implications of these pathologies.     

Low Velocity Impact,Fatigue and Visco-elastic Behaviour of Carbon/E-glass Intra-ply fibre-Reinforced Nano-silica Toughened Epoxy Composite

Silicon - This current research dealing the effect of adding high stiffness carbon fibre along with E-glass fibre and addition of nano-silica particles as a toughening agent in epoxy resin. The...     

Information Systems Offshore Outsourcing: An Exploratory Study of Motivations and Risks in Large Spanish Firms

Prior research has documented that IT investment increases market returns. Economic theories predict such returns to be recognized in accounting profitability; this relationship remains ambiguous in prior literature. We reexamine the relationship between IT investment and firm profitability. Our approach is unique in that we examine complementarities between distinct IT components. We document that a firm’s investments in IT components exhibit different impacts on its profitability conditional on the level of investments in complementary components.     

Complementary Effects of Information Technology Investment on Firm Profitability: The Functional Forms of the Complementarities

Abstract

This paper focuses on developing economic theory on the interrelation between information technology investment components. Three functional forms to model the joint effects between components of investment on firm accounting profitability are identified and empirically tested. The results suggest that the complementarities between components of IT investment can be best modeled by using the multiplicative functional forms, providing a framework to model the joint effects of different factors that impact firm profitability.     

Magnetic quadrupole doublet focusing system for high energy ions

A high energy focused ion beam microprobe using a doublet arrangement of short magnetic quadrupole lenses was used to focus 1-3 MeV protons to spot sizes of 1x1 microm2 and 1-4.5 MeV carbon and silicon ion beams to spot sizes of 1.5x1.5 microm2. The results presented clearly demonstrate that this simple doublet configuration can provide high energy microbeams for microanalysis and microfabrication applications.     

Comprehensive Automation for Specialty Crops: Year 1 results and lessons learned

Comprehensive Automation for Specialty Crops is a project focused on the needs of the specialty crops sector, with a focus on apples and nursery trees. The project’s main thrusts are the integration of robotics technology and plant science; understanding and overcoming socio-economic barriers to technology adoption; and making the results available to growers and stakeholders through a nationwide outreach program. In this article, we present the results obtained and lessons learned in the first year of the project with a reconfigurable mobility infrastructure for autonomous farm driving. We then present sensor systems developed to enable three real-world agricultural applications—insect monitoring, crop load scouting, and caliper measurement—and discuss how they can be deployed autonomously to yield increased production efficiency and reduced labor costs.     

Loop Shifting for Loop Compaction

The idea of decomposed software pipelining is to decouple the software pipelining problem into a cyclic scheduling problem without resource constraints and an acyclic scheduling problem with resource constraints. In terms of loop transformation and code motion, the technique can be formulated as a combination of loop shifting and loop compaction. Loop shifting amounts to moving statements between iterations thereby changing some loop independent dependences into loop carried dependences and vice versa. Then, loop compaction schedules the body of the loop considering only loop independent dependences, but taking into account the details of the target architecture. In this paper, we show how loop shifting can be optimized so as to minimize both the length of the critical path and the number of dependences for loop compaction. The first problem is well-known and can be solved by an algorithm due to Leiserson and Saxe. We show that the second optimization (and the combination with the first one) is also polynomially solvable with a fast graph algorithm, variant of minimum-cost flow algorithms. Finally, we analyze the improvements obtained on loop compaction by experiments on random graphs.     

Arthemis: annotation software in an integrated capturing and analysis system for colonoscopy

Colonoscopy is an endoscopic technique that allows physicians to inspect the inside of the human colon. During a colonoscopic procedure, a tiny video camera at the tip of the endoscope generates a video signal of the internal mucosa of the colon. In current practice, the entire colonoscopic procedure is not routinely captured. Software tools providing easy access to important contents of videos that are digitally captured during colonoscopy are not available. Hence, it is very time consuming to review an entire video, locate important contents, annotate them, and extract the annotated contents for research, teaching, and training purposes. Arthemis, a software application, was developed to facilitate this process. For convenient data sharing, Arthemis allows annotation according to the European Gastrointestinal Society for Endoscopy (ESGE) Minimal Standard Terminology (MST), an internationally accepted standard for digestive endoscopy. Arthemis is part of our integrated capturing and content analysis system for colonoscopy called Endoscopic Multimedia Information System (EMIS). This paper presents Arthemis as a component of EMIS, the design and implementation of Arthemis, and key lessons learned from the development process.     

Molecular dynamics simulations of oscillatory flows in microfluidic channels

In this paper we apply the direct non-equilibrium molecular dynamics technique to oscillatory flows of fluids in microscopic channels. Initially, we show that the microscopic simulations resemble the macroscopic predictions based on the Navier–Stokes equation very well for large channel width, high density and low temperature. Further simulations for high temperature and low density show that the non-slip boundary condition traditionally used in the macroscopic equation is greatly compromised when the fluid–wall interactions are the same as the fluid–fluid interactions. Simulations of a system with very narrow channel width confirm earlier findings of Poiseuille flow, namely, that the velocity profiles are modulated. We find that these modulations cannot be explained by the local area density model.