Effect of the Mn/Fe Ratio on the Microstructure and Magnetic Properties in the Powder Form (Fe<Subscript>1−<Emphasis Type="Italic">x</Emphasis></Subscript>Mn<Subscript><Emphasis Type="Italic">x</Emphasis></Subscript>)<Subscript>2</Subscript>P System

The structure, morphology, and magnetic properties of the mechanically alloyed iron manganese phosphides (Fe_1?x Mn _x )₂P with 0.15 ≤ x ≤ 0.75 (Mn/Fe ratio = 0.17, 0.33, 0.66, and 3) have been studied by means of X-ray diffraction, scanning electron microscopy coupled with energy-dispersive X-ray spectrometry, and BS1 and BS2 magnetometry. The powder form (Fe_1?x Mn _x )₂P compounds exhibit multiphase structures that contain Fe(Mn)-type solid solution and Fe₂P-type, Mn₂P-type, Fe₃P-type, and MnP/FeP-type phosphides. The magnetization versus temperature reveals the existence of multiple magnetic phase transitions. The saturation magnetization, coercivity, and squarness M _r/M _s ratio values are discussed as a function of both the Mn content and the temperature. From the approach to saturation magnetization studies, several fundamental magnetic parameters were extracted. The local magnetic anisotropy constant K ₁ was determined.     

A multi-agent architecture for dynamic scheduling of steel hot rolling

Steel production is a complex process and finding coherent and effective schedules for the wide variety of production steps, in a dynamic environment, is a challenging task. In this paper, we propose a multi-agent architecture for integrated dynamic scheduling of the hot strip mill (HSM) and the continuous caster. The scheduling systems of these processes have very different objectives and constraints, and operate in an environment where there is a substantial quantity of real-time information concerning production failures and customer requests. Each process is assigned to an agent which independently, seeks an optimal dynamic schedule at a local level taking into account local objectives, real-time information and information received from other agents. Each agent can react to real-time events in order to fix any problems that occur. We focus here, particularly, on the HSM agent which uses a tabu search heuristic to create good predictive–reactive schedules quickly. The other agents simulate the production of the coil orders and the real-time events, which occur during the scheduling process. When real-time events occur on the HSM, the HSM agent might decide whether to repair the current schedule or reschedule from scratch. To address this problem, a range of schedule repair and complete rescheduling strategies are investigated and their performance is assessed with respect to measures of utility, stability and robustness, using an experimental simulation framework.     

Modeling and solving a one-supplier multi-vehicle production-inventory-distribution problem with clustered retailers

This paper considers a supply chain management problem which integrates production, inventory, and distribution decisions. The supply chain is composed of one supplier production facility and several retailers located in a given geographic region. The supplier is responsible for the production and the replenishment of the inventory of retailers, in a vendor managed inventory (VMI) context. The distance between retailers is negligible compared to the distance between the supplier and the retailers’ region. Thus, for each vehicle, there is a major fixed cost for traveling to the cluster of retailers and a minor fixed cost for visiting each individual retailer. The problem consists of determining quantities to be produced, quantities to be delivered to retailers, vehicles to be used, and retailers to be serviced by each vehicle. This problem is an extension of the one warehouse multi-retailer problem with the consideration of production planning and storage and vehicle capacity limitations in addition to fixed vehicle utilization costs and retailer servicing costs. The objective is to minimize a total cost composed of production, transportation, and inventory holding costs at the supplier and at the retailers. Two mixed integer linear programming formulations are proposed and six families of valid inequalities are added to strengthen these formulations. Two of these families are new and the others are adapted from the literature. The numerical results show that the valid inequalities considerably improve the quality of the formulations. Moreover, the parameters that influence the most computational times are analyzed.     

X-ray diffraction,Mössbauer spectrometry and thermal studies of the mechanically alloyed (Fe1−xMnx)2P powders

(Fe_1?xMn_x)₂P phosphide powders in the composition range 0.15?≤?x ≤ 0.75 have been mechanically alloyed and their structural, magnetic and thermal changes with composition have been investigated by means of X-ray diffraction, ⁵⁷Fe Mössbauer spectrometry, magnetization measurements and differential scanning calorimetry. The milling process induces changes in the crystal phase diagram of the (Fe_1?xMn_x)₂P system. The XRD results reveal the coexistence of a bcc Fe(Mn)-type, hexagonal (Fe₂P and Mn₂P-type), orthorhombic (MnP-type) and tetragonal Fe₃P-type structures for all compositions. The room temperature Mössbauer spectra confirm the formation of the Fe(Mn)-type, non-stoichiometric Fe₂P-type, FeP-type and Fe₃P-type structures. Saturation magnetization exhibits a comparable behavior to that of the average hyperfine magnetic field. The DSC scans show the existence of several endothermic and exothermic peaks in the temperature range (100–700)?°C related to different phase transitions. The endothermic peak at about 582–589?°C can be related to the ferromagnetic/paramagnetic transition temperature (Curie temperature, T_C) of the Fe(Mn)-type structure.     

Immunogenicity of four Plasmodium falciparum preerythrocytic antigens in Aotus lemurinus monkeys

Aotus lemurinus monkeys were immunized with pools of either lipid-tailed peptides injected in PBS or peptides in Montanide ISA-51, all derived from four Plasmodium falciparum pre-erythrocytic antigens, namely, LSA1, LSA3, SALSA, and STARP. These formulations were well tolerated. Their immunogenicity was demonstrated by the induction of both B- and T-cell responses to most of the peptides studied (of the 12, 10 induced antibody production, 9 induced T-cell proliferative responses, and all 12 induced gamma interferon secretion). Immune responses proved to be long lasting, since some were still detectable 210 days after immunization. Of particular importance is the fact that B- and T-cell responses elicited in this way by synthetic peptides were specific for native parasite proteins on P. falciparum sporozoites and liver stage parasites.     

Cooperative search for fair nurse rosters

The development of decision support systems acceptable for nurse rostering practitioners still presents a daunting challenge. Building on an existing nurse rostering problem, a set of fairness-based objective functions recently introduced in the literature has been extended. To this end, a generic agent-based cooperative search framework utilising new mechanisms is described, aiming to combine the strengths of multiple metaheuristics. These different metaheuristics represent individual planners’ implicit procedures for improving rosters. The framework enables to explore different ways of assessing nurse rosters in terms of fairness objectives. Computational experiments have been conducted across a set of benchmark instances. The overall results indicate that the proposed cooperative search for fair nurse rosters outperforms each metaheuristic run individually.     

Polymeric compounds in activated sludge supernatant -- Characterisation and retention mechanisms at a full-scale municipal membrane bioreactor

In this study, for the first time a full-scale membrane bioreactor (MBR) was investigated with focus on organic compounds in activated sludge over a period of approximately 2 years. Soluble extracellular polymeric substances (EPS) in the sludge supernatant and permeate as well as bound EPS extracted from fouled membranes were determined photospectrometrically and revealed a typical composition of three main components in the order metals>humic acids>carbohydrates>proteins. Results showed an important influence on membrane fouling by soluble humic substances and carbohydrates in complexes with metal cations. It was found that Fe(2+) and Fe(3+) play a decisive role in natural organic matter (NOM) complexation and subsequent membrane blockage. The determination of molar mass distribution in supernatant and permeate by size exclusion chromatography (SEC) revealed a significant retention of macromolecular compounds by the porous membranes in the range of 10-50%.     

Simulating and modeling the breakdown voltage in a semi-insulating GaAs P+N junction diode

This work aims to determine the characteristic PN junction diode, subject to a reverse polarization, while I （breakdown voltage） of the inverse current in a GaAs specifying the parameters that influence the breakdown voltage of the diode. In this work, we simulated the behavior of the ionization phenomenon by impact breakdown by avalanche of the PN junctions, subject to an inverse polarization. We will take into account both the trapping model in a stationary regime in the P＋N structure using like material of basis the Ⅲ-Ⅴ compounds and mainly the GaAs semi-insulating in which the deep centers have in important densities. We are talking about the model of trapping in the space charge region （SCR） and that is the trap density donor and acceptor states. The carrier crossing the space charge region （SCR） of W thickness creates N electron-hole pairs： for every created pair, the electron and the hole are swept quickly by the electric field, each in an opposite direction, which comes back, according to an already accepted reasoning, to the crossing of the space charge region （SCR） by an electron or a hole. So the even N pair created by the initial particle provoke N2 ionizations and so forth. The study of the physical and electrical behaviour of semiconductors is based on the influence of the presence of deep centers on the characteristic I（V） current-tension, which requires the calculation of the electrostatic potential, the electric field, the integral of ionization, the density of the states traps, the diffusion current of minority in the regions （1） and （3）, the current thermal generation in the region （2）, the leakage current in the surface, and the breakdown voltage.     

Validation of the in vivo intravascular ultrasound measurement of in-stent neointimal hyperplasia volumes

OBJECTIVES: This study was undertaken to validate the in vivo intravascular ultrasound (IVUS) measurement of in-stent neointimal hyperplasia (IH) volumes. BACKGROUND: Because stents reduce restenosis compared to balloon angioplasty, stent use has increased significantly. As a result, in-stent restenosis is now an important clinical problem. Serial IVUS studies have shown that in-stent restenosis is secondary to intimal hyperplasia. To evaluate strategies to reduce in-stent restenosis, accurate measurement of in-stent neointimal tissue is important. METHODS: Using a porcine coronary artery model of in-stent restenosis, single Palmaz-Schatz stents were implanted into 16 animals with a stent:artery ratio of 1.3:1. Intravascular ultrasound imaging was performed at 1 month, immediately prior to animal sacrifice. In vivo IVUS and ex vivo histomorphometric measurements included stent, lumen and IH areas; IH volumes were calculated with Simpson's rule. RESULTS: Intravascular ultrasound measurements of IH (30.4+/-11.0 mm3) volumes correlated strongly with histomorphometric measurements (26.7+/-8.5 mm3, r=0.965, p < 0.0001). The difference between the IVUS and the histomorphometric measurements of IVUS volume was 4.1+/-2.7 mm3 or 15.8+/-11% (standard error of the estimate=0.7). Both histomorphometry and IVUS showed that IH was concentric and uniformly distributed over the length of the stent. Intravascular ultrasound detected neointimal thickening of < or =0.2 mm in 5 of 16 stents. Sample size calculations based on the IVUS measurement of IH volumes showed that 12 stented lesions/arm would be required to show a 50% reduction in IVUS-measured IH volume and 44 stented lesions/arm would be required to show a 25% reduction in IH volume. CONCLUSION: In vivo IVUS measurement of IH volumes correlated strongly with ex vivo histomorphometry. Using volumetric IVUS end points, small sample sizes should be necessary to demonstrate effectiveness of strategies to reduce in-stent restenosis.     

Change in nasopharyngeal carriage of Streptococcus pneumoniae resulting from antibiotic therapy for acute otitis media in children

Although theophylline has been used in the treatment of asthma for decades, it is not a first line choice any more. It is a well-known bronchodilator, but was recently discovered also to be an anti-inflammatory, immunomodulatory and bronchoprotective agent. Therefore we wanted to establish the role of theophylline on prostaglandin and leukotriene production, which plays a part in the pathogenesis of asthma. Theophylline was infused (bolus 5 mg/kg in 15 min and infusion 0.4 mg/kg/h for 1 h 45 min) into healthy volunteers. Thromboxane B2, prostaglandin E2 and leukotriene E4 were measured from the A23187-stimulated whole blood samples and stable metabolites of thromboxane A2; prostacyclin and leukotriene E4 were measured from urine. Theophylline increased prostaglandin E2 production and decreased leukotriene E4 production ex vivo in whole blood, thus increasing the prostanoid/leukotriene ratio. It did not change thromboxane B2 production stimulated by either spontaneous clotting or A23187 in the whole blood. Theophylline had hardly any effect on in vivo thromboxane, prostacyclin and leukotriene E4 production measured as urinary metabolites, 11-dehydro-thromboxane B2, 2,3-dinor-6-keto-prostaglandin F1alpha and leukotriene E4, respectively. Serum theophylline concentrations were at the lower level of normal therapeutic range during the infusion. The increase in PGE2 and the decrease in LTE4 synthesis ex vivo may offer a new explanation for the mode of antiasthmatic action of theophylline. It is notable that this phenomenon occurs at low serum theophylline concentrations. These results confirm the idea that theophylline has an anti-inflammatory and bronchoprotective action and support the use of theophylline as a therapeutic agent in asthmatic patients.