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排序方式: 共有716条查询结果,搜索用时 15 毫秒
1.
Alice Maurer Prof. Dr. Florian P. Seebeck 《Chembiochem : a European journal of chemical biology》2020,21(20):2908-2911
Ergothioneine has emerged as a crucial cytoprotectant in the pathogenic lifestyle of Mycobacterium tuberculosis. Production of this antioxidant from primary metabolites may be regulated by phosphorylation of Thr213 in the active site of the methyltransferase EgtD. The structure of mycobacterial EgtD suggests that this post-translational modification would require a large-scale change in conformation to make the active-site residue accessible to a protein kinase. In this report, we show that, under in vitro conditions, EgtD is not a substrate of protein kinase PknD. 相似文献
2.
Yu. N. Denisyuk N. M. Ganzherli I. M. Maurer S. A. Pisarevskaya 《Technical Physics Letters》1997,23(4):279-280
A thick-layer light-sensitive material consisting of glycerin-containing bichromated gelatin has been prepared and used to
record real-time volume holograms with 0.44 μm helium-cadmium laser radiation. The thickness of the layers is 400–600 μm.
The holographic sensitivity of the material is 1 J/cm2. The highest diffraction efficiency of holograms recorded using a symmetric system with parallel beams is 32%.
Pis’ma Zh. Tekh. Fiz. 23, 62–65 (April 12, 1997) 相似文献
3.
A new diffuser capable of scattering light in one direction (one-dimensional diffuser) has been developed and experimentally
tested. The diffuser is formed in a thick layer of dichromated gelatin. The scattering indicatrices of the diffuser measured
in two mutually perpendicular directions are presented. It is demonstrated that the indicatrix width in one direction is significantly
greater than that in the perpendicular direc-tion. However, no zero-order diffraction has been observed. The proposed one-dimensional
diffuser exhibits close scattering indicatrices for reading at a wavelength of 0.44 and 0.63 μm. 相似文献
4.
Prof. Dr.-Ing. A. M. Miri Dipl.-Ing. F. Schunn Dipl.-Ing. C. Sihler Dr. W. W. Maurer Dr. A. Ulbricht 《Electrical Engineering (Archiv fur Elektrotechnik)》1995,78(4):223-228
Übersicht Um die Betriebssicherheit großer supraleitender Magnetsysteme für die Kernfusionsforschung zu gewährleisten, muß die im Magnetsystem gespeicherte Energie schnell entladen werden können. Durch die veränderlichen großvolumigen Magnetfelder werden in benachbarten leitfähigen Strukturen durch Induktion hohe Wirbelströme hervorgerufen. Durch sie treten dort elektromagnetische Kräfte. auf, die einzelne Komponenten mechanisch überlasten können. Zur Berechnung dieser Kräfte wurde eine einfache numerischanalytische Methode entwickelt, die im folgenden vorgestellt und mit Finite-Elemente-Verfahren verglichen wird.
Calculation of eddy current densities and forces around large superconducting coils for nuclear fusion
Contents The reliable operation of the superconducting magnet systems used for the magnetic confinement in nuclear fusion research requires the ability of a fast discharge of the stored magnetic energy. The corresponding magnetic field variation gives rise to high eddy currents by inductive coupling with surrounding conductive components. The eddy current forces can lead to a mechanical overload of some of these components. A simple numerical-analytical method was developed in order to calculate these forces. This method is presented and compared with the Finite Element Method.相似文献
5.
6.
H. Maurer O. Univ.-Prof. Dr. phil. 《e & i Elektrotechnik und Informationstechnik》2003,120(11):411-413
In this article it is argued that in ten years’ time personal computers as we know them now won’t exist anymore — all their functions will by then be integrated in mobiles which will be our steady companions. As such, mobiles will change our lives to an enormous extent. Technology as well as consequences will be discussed in this paper. 相似文献
7.
M Clodi R Oberbauer W Waldh?usl G Maurer GM Kostner K Kostner 《Canadian Metallurgical Quarterly》1997,40(12):1455-1460
Lp(a), one of the most atherogenic lipoproteins, is believed to contribute significantly to vascular diseases in non-insulin-dependent diabetic (NIDDM) patients. Contradictive data have been published on these patients concerning plasma concentrations of Lp(a) and their relation to renal function. Since apo(a) fragments appear in urine, we measured urinary apo(a) in 134 NIDDM patients and 100 matched controls and related urinary apo(a) concentrations to plasma Lp(a) levels and kidney function. Plasma Lp(a) values were found to be significantly higher in NIDDM patients. NIDDM patients also secreted significantly more apo(a) into their urine as compared to control subjects. There was no correlation between creatinine clearance or albumin excretion and urinary apo(a) concentrations. Patients with macroalbuminuria exhibited a twofold higher apparent fractional excretion of apo(a) in comparison to patients with normal renal function. Urinary apo(a) values in both patients and control subjects were highly correlated to plasma Lp(a), yet no correlation was found with HbA1c or serum lipoproteins. It is concluded that urinary apo(a) excretion is correlated to plasma Lp(a) levels but not to creatinine clearance in patients suffering from NIDDM. 相似文献
8.
DB Fenske KF Wong E Maurer N Maurer JM Leenhouts N Boman L Amankwa PR Cullis 《Canadian Metallurgical Quarterly》1998,1414(1-2):188-204
A new method, based on the ion-translocating properties of the ionophores nigericin and A23187, is described for loading large unilamellar vesicles (LUVs) with the drugs vincristine and ciprofloxacin. LUVs composed of distearoylphosphatidylcholine/cholesterol (DSPC/Chol) (55:45 mol/mol) or sphingomyelin (SPM)/Chol (55:45 mol/mol) exhibiting a transmembrane salt gradient (for example, internal solution 300 mM MnSO4 or K2SO4; external solution 300 mM sucrose) are incubated in the presence of drug and, for experiments involving divalent cations, the chelator EDTA. The addition of ionophore couples the outward movement of the entrapped cation to the inward movement of protons, thus acidifying the vesicle interior. External drugs that are weak bases can be taken up in response to this induced transmembrane pH gradient. It is shown that both nigericin and A23187 facilitate the rapid uptake of vincristine and ciprofloxacin, with entrapment levels approaching 100% and excellent retention in vitro. Following drug loading, the ionophores can be removed by gel exclusion chromatography, dialysis, or treatment with biobeads. In vitro leakage assays (addition of 50% mouse serum) and in vivo pharmacokinetic studies (in mice) reveal that the A23187/Mn2+ system exhibits superior drug retention over the nigericin/K+ system, and compares favorably with vesicles loaded by the standard DeltapH or amine methods. The unique features of this methodology and possible benefits are discussed. 相似文献
9.
Examined perceived environment, perceived incentive and outcome, and person constructs for relationships with interest and participation in voluntary learning and development activity by nonmanagement employees. All 3 groups of constructs were related to development activity. In relationships with development activity, perceived outcome and environment variables interacted with workers' personal values relevant to aspects of a development setting, illustrating the potentially important role that differences in values may play in a development context. Additionally, small relationships were observed between several demographic variables and values within a development setting. Results provide implications for the design and implementation of successful development programs and highlight the need to carefully consider individual differences in this context when targeting many different types of employees for participation. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献
10.