Evaluation of the stability and analysis of halogenated furanones in disinfected drinking waters

A refined method for the sub-nanomolar analysis of 13 halogenated furanones in chlorinated drinking water is proposed which uses liquid-liquid extraction, methylation where necessary, gas chromatographic separation, and either micro-electron capture or ion trap mass spectrometric detection. Liquid-liquid extraction with methyl tert-butyl ether was demonstrated to be effective for recovery of halogenated furanones. Confirmation of the halogenated furanones identity and reduction of natural organic matter interference were achieved by ion trap tandem mass spectrometry. Compound stabilities and procedural efficiencies were evaluated to permit optimization of the method for reasonable sample volumes and a 1000:1 pre-concentration factor that would permit feasible sample collection in the field. Both chlorinated and brominated analogues of MX (3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone) were included in a suite of compounds targeted in a national occurrence study of disinfection by-products.     

Thiophene systems. 7. Pyrido[3,2-b]thieno[3,4-e][1,4]diazepine derivatives with potential cns activity

Pyrido[3,2-b]thieno[3,4-e][1,4]diazepines ( 1a-d ) were synthesized to investigate their potential CNS activity. Synthesis of the desired ring system was effected by condensation of 2,3-diaminopyridine ( 3 ) with methyl tetrahydro-4-oxo-3-thiophenecarboxylate ( 4 ). Structural assignment of the major condensation product 5 was determined by comparison of ¹H nmr absorptions of 5 with those of related methyl lactam derivatives 11 and 14. A discussion of the possible mechanism leading to 5 in preference to isomeric lactam 6 is presented. Biological evaluation of 1a-d revealed no interesting properties.     

Transition‐Metal‐Free Formal Sonogashira Coupling and α‐Carbonyl Arylation Reactions

Transition‐metal‐free formal Sonogashira coupling and α‐carbonyl arylation reactions have been developed. These transformations are based on the nucleophilic aromatic substitution (S_NAr) of β‐carbonyl sulfones to electron‐deficient aryl fluorides, producing a key intermediate that, depending on the reaction conditions, gives the aromatic alkynes or α‐aryl carbonyl compounds. The development of these reactions is presented and, based on investigations under basic and acidic conditions, mechanisms have been proposed. To develop the formal Sonogashira coupling further, a milder, two‐step protocol is also disclosed that expands the reaction concept. The scope of these reactions is demonstrated for the synthesis of Sonogashira and α‐carbonyl arylated products from a range of electron‐deficient aryl fluorides with a variety of functional groups and aryl‐, heteroaryl‐, alkyl‐, and alkoxy‐substituted sulfone nucleophiles. These transition‐metal‐free reactions complement the metal‐catalyzed versions in terms of substitution patterns, simplicity, and reaction conditions.     

Total synthesis of clathculins A and B

Clathculins A and B represent a new class of vic-diamine alkaloids containing a PA2 unit as the basic structure. We report the first total syntheses of 1 and 2, which confirm the assigned structure of each. Dependence of their NMR spectroscopic behavior as a function of protonation state has been observed.     

Synthesis of 5,7-dihydrobenzo[a]phenazin-5-one derivatives

The synthesis, purification and spectroscopic characterization of several phenazines was undertaken with the goal of discovering useful or improved fluorescent probes.     

Continuous and pulsed quantum zeno effect

Continuous and pulsed quantum Zeno effects were observed using a 87Rb Bose-Einstein condensate. Oscillations between two ground hyperfine states of a magnetically trapped condensate, externally driven at a transition rate omega(R), were suppressed by destructively measuring the population in one of the states with resonant light. The suppression of the transition rate in the two-level system was quantified for pulsed measurements with a time interval deltat between pulses and continuous measurements with a scattering rate gamma. We observe that the continuous measurements exhibit the same suppression in the transition rate as the pulsed measurements when gammadeltat=3.60(0.43), in agreement with the predicted value of 4. Increasing the measurement rate suppressed the transition rate down to 0.005 omega(R).     

Parametric amplification of scattered atom pairs

We have observed parametric generation and amplification of ultracold atom pairs. A 87Rb Bose-Einstein condensate was loaded into a one-dimensional optical lattice with quasimomentum k0 and spontaneously scattered into two final states with quasimomenta k1 and k2 . Furthermore, when a seed of atoms was first created with quasimomentum k1 we observed parametric amplification of scattered atoms pairs in states k1 and k2 when the phase-matching condition was fulfilled. This process is analogous to optical parametric generation and amplification of photons and could be used to efficiently create entangled pairs of atoms. Furthermore, these results explain the dynamic instability of condensates in moving lattices observed in recent experiments.     

Parameter choices and a better bound on the list size in the Guruswami–Sudan algorithm for algebraic geometry codes

Given an algebraic geometry code C_L(D, aP){C_{\mathcal L}(D, \alpha P)}, the Guruswami–Sudan algorithm produces a list of all codewords in C_L(D, aP){C_{\mathcal L}(D, \alpha P)} within a specified distance of a received word. The initialization step in the algorithm involves parameter choices that bound the degree of the interpolating polynomial and hence the length of the list of codewords generated. In this paper, we use simple properties of discriminants of polynomials over finite fields to provide improved parameter choices for the Guruswami–Sudan list decoding algorithm for algebraic geometry codes. As a consequence, we obtain a better bound on the list size as well as a lower degree interpolating polynomial.     

Highly Coherent Spectroscopy of Ultracold Atoms and Molecules in Optical Lattices

Cooling and trapping of neutral atoms using laser techniques has enabled extensive progress in precise, coherent spectroscopy. In particular, trapping ultracold atoms in optical lattices in a tight confinement regime allows us to perform high‐resolution spectroscopy unaffected by atomic motion. We report on the recent developments of optical lattice atomic clocks that have led to optical spectroscopy coherent at the one second timescale. The lattice clock techniques also open a promising pathway toward trapped ultracold molecules and the possible precision measurement opportunities such molecules offer.