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A novel pH-sensitive complex was prepared by using oxidized konjac glucomannan and 4-aminosalicylic acid (4-ASA) through glutaraldehyde
as a cross-linking agent. The product was characterized by FTIR and 13C NMR spectra, and the thermogravimetric analysis was also studied. The drug release studies in vitro showed that the amount of 4-ASA released from the complex was about 4%, 56% and 17% after 12 h at pH 1.2, 6.8 and 7.4, respectively.
The data demonstrate that the rate of the drug release of the complex can be more effectively controlled by pH value. The
results showed that the novel pH-sensitive complex could be potentially useful for colon-targeting drug delivery system. 相似文献
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通过在水中复配魔芋葡甘聚糖(KGM)、黄原胶(XG)和β-环糊精(β-CD),制备了KGM/XG/β-CD复合水凝胶。探讨了β-CD含量对凝胶平衡溶胀度的影响,并探讨了介质pH和温度对凝胶溶胀度的影响。结果表明,当m(KGM):m(XG):m(β-CD)=1:1:1时,复合凝胶的平衡溶胀度最大;复合凝胶的溶胀度在溶胀初期增加很快,随着溶胀时间的延长,溶胀度增加变慢,约7 h内基本达到平衡;随着介质pH的增大或体系温度从25℃增加至37℃,KGM/XG/β-CD复合凝胶的溶胀度随之增大。 相似文献
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A novel pH-sensitive complex was prepared by using oxidized konjac glucomannan and 4-aminosalicylic acid (4-ASA) through glutaraldehyde as a cross-linking agent. The product was characterized by FTIR and 13C NMR spectra, and the thermogravimetric analysis was also studied. The drug release studies in vitro showed that the amount of 4-ASA released from the complex was about 4%, 56% and 17% after 12 h at pH 1.2, 6.8 and 7.4, respectively. The data demonstrate that the rate of the drug release of the complex c... 相似文献
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以魔芋葡甘聚糖(KGM)-黄原胶(XG)共混多糖为载体,进一步复配β-环糊精(β-CD)得到KGM/XG/β-CD复合干凝胶;以香兰素为模型香精,制备了装载香精的KGM/XG/β-CD复合凝胶,研究了装载香兰素的复合凝胶的释放行为,并与KGM/XG复合凝胶的释放行为做了比较。结果表明:在p H分别为5,7和9的缓冲液中,KGM/XG/β-CD复合凝胶中的香兰素12 h后累积释放率分别为29.5%,47.7%和60.6%,较KGM/XG复合凝胶中的香兰素在12 h后累积释放率(分别为45.0%,69.3和82.3%)低,表明具有空腔结构的β-CD对香兰素的释放起到了较好的缓释作用。 相似文献
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结构可控PBMA-b-PSt嵌段共聚物的合成及结构表征 总被引:1,自引:0,他引:1
原子转移自由基聚合(ATRP)方法是一种新发展起来的可控/“活性”自由基聚合方法,在合成结构可控共聚物过程中具有广泛应用。采用二步加料方式的ATRP方法合成了一系列具有可控结构的PBMA-b-PSt嵌段共聚物,聚合物的分子量分布小于1.5,分子量可简单地通过改变反应投料单体/引发剂比及控制单体转化率得到调控,同时对嵌段共聚物的结构进行了IR,^1H-NMR,PGC,DSC表征,确证了其结构。结果表明,所合成的嵌段共聚物具有PBMA-b-PSt-X和PSt-b-PBMA-X的结构特征。 相似文献
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