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Quan-Qi Yu Juan-Juan Gao Xue-Xian Lang Hong-Yao Li Prof. Ming-Qi Wang 《Chembiochem : a European journal of chemical biology》2021,22(6):1042-1048
The development of small molecules that can selectively target G-quadruplex (G4) DNAs has drawn considerable attention due to their unique physiological and pathological functions. However, only a few molecules have been found to selectively bind a particular G4 DNA structure. We have developed a fluorescence ligand Q1 , a molecular scaffold with a carbazole–pyridine core bridged by a phenylboronic acid side chain, that acts as a selective ascaris telomere antiparallel G4 DNA ASC20 ligand with about 18 nm blue-shifted and enhanced fluorescence intensity. Photophysical properties revealed that Q1 was sensitive to the microenvironment and gave the best selectivity to ASC20 with an equilibrium binding constant Ka=6.04×105 M−1. Time-resolved fluorescence studies also demonstrated that Q1 showed a longer fluorescence lifetime in the presence of ASC20. The binding characteristics of Q1 with ASC20 were shown in detail in a fluorescent intercalator displacement (FID) assay, a 2-Ap titration experiment and by molecular docking. Ligand Q1 could adopt an appropriate pose at terminal G-quartets of ASC20 through multiple interactions including π–π stacking between aromatic rings; this led to strong fluorescence enhancement. In addition, a co-staining image showed that Q1 is mainly distributed in the cytoplasm. Accordingly, this work provides insights for the development of ligands that selectively targeting a specific G4 DNA structure. 相似文献
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Under the circumstance of perceptual consumption, it is still challenging to grasp consumer's emotions and demands due to the large search space, diversified preferences, and easy fatigue of consumers. To reduce user fatigue and enlarge search space, a novel method was presented to design and optimize the pattern of yarn-dyed plaid fabric using the isolation niche genetic algorithm and rough set theory. Each pattern was encoded as a chromosome based on the real number code. The population was initialized and evolved using INGA to maintain the diversity. The rough set theory was adopted as the fitness function of isolation niche genetic algorithm to extract the consumer's demands. After multiple evolutions, a large set of practical patterns of the yarn-dyed plaid fabric are obtained. Experiments were carried out by 24 testers of different ages and genders. The results prove that the proposed method based on the isolation niche genetic algorithm and rough set theory is feasible and effective, supplying references to the designer. 相似文献
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文章设计了一种具有可调增益功能的振动监测系统。首先从监测层和测量层两个方面提出了振动监测系统的整体框架,之后给出了硬件系统和软件系统的设计方法及软件实现代码,利用控制芯片和可调增益放大器,在监测系统中整合了一套可根据采集信号幅值大小调整增益的数据采集装置;利用模拟信号发生器对不加增益和设置可调增益之后的两种信号进行了对比分析,并在汽轮发电机组实际工况下进行了振动信号采集。结果表明,具备可调增益功能的振动监测系统可有效提高采集信号的信噪比,提高汽轮发电机组的振动监测能力。 相似文献
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属性约简是粗糙集理论的重要应用。考虑将决策表中的每行都作为一条决策规则时,若把表中出现相同决策规则的次数作为权,可得到带权决策表。提出了关于带权决策表的正域约简相应的辨识矩阵并给出了证明,从而得到了约简算法。相比于决策表中的正域约简时发现,通过将决策表转化为带权决策表后,再利用算法1进行约简时,其在一定程度上优于前者。提出了近似分类精度约简相应的辨识矩阵并给出了证明。对于2个算法,在选取的UCI数据集上进行了实验验证。通过实验进一步说明了所提出算法的可行性和有效性。 相似文献
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To design robust interval observers for uncertain continuous‐time linear systems, a new set‐integration approach is proposed to compute trajectory tubes for the estimation error. Because this approach, the order‐preserving condition on the dynamics of the estimation error is no longer required. Therefore, synthesis methods can be used to compute observer gains that reduce the impact of the system uncertainties on the accuracy of the estimated state enclosures. The performance of the proposed approach is showcased through illustrative numerical examples. 相似文献
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