全文获取类型
收费全文 | 2210篇 |
免费 | 443篇 |
国内免费 | 14篇 |
学科分类
工业技术 | 2667篇 |
出版年
2024年 | 12篇 |
2023年 | 85篇 |
2022年 | 88篇 |
2021年 | 183篇 |
2020年 | 121篇 |
2019年 | 195篇 |
2018年 | 142篇 |
2017年 | 123篇 |
2016年 | 122篇 |
2015年 | 137篇 |
2014年 | 101篇 |
2013年 | 146篇 |
2012年 | 184篇 |
2011年 | 211篇 |
2010年 | 132篇 |
2009年 | 130篇 |
2008年 | 106篇 |
2007年 | 115篇 |
2006年 | 88篇 |
2005年 | 71篇 |
2004年 | 44篇 |
2003年 | 44篇 |
2002年 | 27篇 |
2001年 | 8篇 |
2000年 | 7篇 |
1999年 | 6篇 |
1998年 | 4篇 |
1997年 | 3篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 4篇 |
1992年 | 3篇 |
1991年 | 1篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1988年 | 3篇 |
1986年 | 2篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1980年 | 2篇 |
排序方式: 共有2667条查询结果,搜索用时 46 毫秒
91.
通过米曲霉固态发酵花生粕,结合酶解与冷冻干燥技术,制备花生肽。促生长实验表明,以0.5%添加分子量小于3ku的花生肽对保加利亚乳杆菌的促生长作用更为明显,其中乳杆菌的活菌数可提高1个数量级,凝乳效果改善,乙醛含量增加。比较氨基酸组成结果表明,该技术可有效提高氨基酸含量,改善氨基酸组成,乳杆菌生长必需的氨基酸含量达33.61~226.33mg/g。 相似文献
92.
93.
94.
Yuefei Wang Renliang Huang Wei Qi Yanyan Xie Mengfan Wang Rongxin Su Zhimin He 《Small (Weinheim an der Bergstrasse, Germany)》2015,11(24):2893-2902
The wetting and drying of drops on flexible fibers occurs ubiquitously in nature, and the capillary force underlying this phenomenon has motivated our great interest in learning how to direct supramolecular self‐assembly. Here, the hierarchical co‐assembly of two aromatic peptides, diphenylalanine (FF) and ferrocene‐diphenylalanine (Fc‐FF), is reported via sequential, combinatorial assembly. The resulting dandelion‐like microstructures have highly complex architectures, where FF microtube arrays serve as the scapes and the Fc‐FF nanofibers serve as the flower heads. Homogeneous FF microtubes with diameters tailored between 1 and 9 μm and wall thickness ranging from 70 to 950 nm are initially formed by controlling the degree of supersaturation of the FF and the water content. Once the FF microtubes are formed, the growth of the dandelion‐like microstructures is then driven by the capillary force, derived from the wetting and drying of the Fc‐FF solution on the FF microtubes. This simple and ingenious strategy offers many opportunities to develop new and creative methods for controlling the hierarchical self‐assembly of peptides and thus building highly complex nano and microstructures. 相似文献
95.
Photoswitchable Membranes Based on Peptide‐Modified Nanoporous Anodic Alumina: Toward Smart Membranes for On‐Demand Molecular Transport 下载免费PDF全文
96.
97.
Nishant Singh Marta Tena-Solsona Juan F. Miravet Beatriu Escuder 《Israel journal of chemistry》2015,55(6-7):711-723
Self-assembly of small peptides offers unique opportunities for the bottom-up construction of supramolecular catalysts that aim to emulate the efficiency and selectivity of natural enzymes. Small, information-rich, simple molecules based on amino acids can self-organise autonomously into complex systems with emergent catalytic properties. The power of noncovalent interactions can be used to construct supramolecular peptidic tertiary structures. Moreover, specific functional groups present in amino acid side-chains may present either a catalytic activity by themselves or be able to bind cofactors such as metal ions. In this scenario, although relevant progress has been achieved in recent years, promising applications in biomaterials science are foreseen. In this review, we discuss the state-of-the-art of this approach at the interface between supramolecular chemistry and peptide science. 相似文献
98.
Avigail Baruch Leshem Shlomo Zarzhitsky Hanna Rapaport 《Israel journal of chemistry》2015,55(6-7):661-670
Amphiphilic peptides can be designed to form ordered supramolecular structures at hydrophilic-hydrophobic interfaces. These systems rely on the ability of peptides to fold into certain secondary structures at interfaces. This review focuses on the design of amphiphilic β-sheet peptide assemblies in monolayers at interfaces, and their relevance to inducing mineralization and interactions with specific ions. In addition, the review discusses recent studies demonstrating the applicability of designed amphiphilic β-sheet peptides to detection of specific small molecules and to elucidating intermolecular interactions relevant to drug delivery and enzyme catalysis systems. 相似文献
99.
Subcritical hydrolysis and characterization of waste proteinaceous biomass for value added applications 总被引:1,自引:0,他引:1 下载免费PDF全文
100.
Julio Valdivia-Silva Jaciel Medina-Tamayo Eduardo A. Garcia-Zepeda 《International journal of molecular sciences》2015,16(6):12958-12985
Chemokines are a burgeoning family of chemotactic cytokines displaying a broad array of functions such as regulation of homeostatic leukocyte traffic and development, as well as activating the innate immune system. Their role in controlling early and late inflammatory stages is now well recognized. An improper balance either in chemokine synthesis or chemokine receptor expression contributes to various pathological disorders making chemokines and their receptors a useful therapeutic target. Research in this area is progressing rapidly, and development of novel agents based on chemokine/chemokine receptors antagonist functions are emerging as attractive alternative drugs. Some of these novel agents include generation of chemokine-derived peptides (CDP) with potential agonist and antagonist effects on inflammation, cancer and against bacterial infections. CDP have been generated mainly from N- and C-terminus chemokine sequences with subsequent modifications such as truncations or elongations. In this review, we present a glimpse of the different pharmacological actions reported for CDP and our current understanding regarding the potential use of CDP alone or as part of the novel therapies proposed in the treatment of microbial infections and cancer. 相似文献