酶学,B型超声,CT及ERCP检查对慢性胰腺炎与胰腺癌的鉴别诊断价值

对经手术和/或病理证实的130例慢性胰腺炎和101例胰腺癌的酶学、B型超声、CT及ERCP检查对比分析。结果表明胰腺癌组ALP和γ-GT明显高于慢性胰腺炎组（ALP84.9％与32.1％，γ-GT93.8％与57.l％，p＜0.01）。B型超声对慢性胰腺炎与胰腺癌的诊断正确率分别为65.7％与72.9％（p＞0.05），CT分别为64.0％与80.0％（p＞0.05），ERCP分别为37.3％与72.7％（p＜0.01）。结果提示ALP/γ-GT与ERCP对慢性胰腺炎与膜腺癌有鉴别诊断意义。     

职业性锰暴露工人健康状况调查分析

对１８２名职业性暴露于锰的电焊工人和１５４名无锰及其它重金属暴露史的对照工人进行健康状况调查，发现暴露组神经系统改变发生率为２６．９６，比数比为２．６２，并且锰暴露年数与神经系统改变呈剂量－反应关系。     

共同性斜视术后的回退问题

共同性斜视矫正术后,近期为双眼正位,但时间长后又能出现以下几种变化:①眼位回退到原斜视方向,②眼位向原斜视方向的相反方向移行;③保持双眼正位。如果我们能将引起眼位变化的因素加以分析,以指导我们手术,会提高斜视矫正手术成功率。现我们将我院的48例共同性斜视(共同性外斜30例,共同性内斜18例)矫正术3年后的情况报告如下:对象和方法一、一般资料;本组病例系1987年12月     

普外术后病人行肠外营养的临床疗效分析

Theanalysisoftheeffecofnutriton(PN)ingeneralsurgicalpostoperativepatientsShaJinhui,ChenYongxiang,JinGuanghua,etal.DepartmentofGeneralSurgery,theMunicipalCentralHospitalofChangChou130051材料与方法一、一般资料PN组：男性8例，女性4例，年龄35～82岁，平均58岁。其中重症胰腺炎3例，胃癌2例，十二指肠球部溃疡五例，结肠癌4例，粘连性绞窄性肠梗阻2例。对照组：男性6例，女性6例，年龄42～74岁，平均53．6岁。其中重症胰腺炎2例，男癌4例，胃溃疡1例，结肠癌3例，广泛性小肠坏死1例，粘连性绞窄性肠梗阻1例。二、两组…     

企业纵横

◎ “中国医院信息化建设推进工程”项目研讨会在京隆重召开“中国医院信息化建设推进工程”项目研讨会于2004年8月8日上午在北京友谊宾馆隆重召开,卫生部原部长钱信忠、国家发展研究中心局长邓寿鹏、信息产业部电子信息中心副主任刘献军等领导应邀出席了会议。随着信息技术的不断发展和人们对医疗保健水平要求的不断提高,建设数字化医院已越来越引起业内外人士的普遍关注并取得初步成效。但建设速度还落后于时代发展步伐。中国信息化推进联盟医药卫生专业委员会针对当前我国医院信息化建设的实际,与北京中科恒业创新科技有限公司等具有技术…     

Rosiglitazone down-regulates lipopolysaccharide-induced expression of CD40 and intercellular adhesion molecule 1 in rat peritoneal mesothelial cells through a NF-κB dependent mechanism

Objective To investigate the effect and mechanism by which PPARγ ligand, rosiglitasone, regulates the expression of CD40 and intercellular adhesion molecule 1 (ICAM-1) in the rat peritoneal mesothelial cells (RPMCs) induced by lipopolysaccharide (LPS). Methods RPMCs were harvested from Sprague-Dawley rat peritoneal cavity and maintained under defined in vitro conditions. The cells were randomly divided into groups as follows: medium, LPS (5 mg/L), LPS (5 mg/L)+BAY11-7085(5 μmol/L, NF-κB inhibitor), rosiglitazone (10 μmol/L or 20 μmol/L, peroxisome proliferator-activated receptor γ activator), LPS (5 mg/L)+rosiglitazone (10 μmol/L)+GW9662 (3 μmol/L, peroxisome proliferator-aetivatcd receptor γ antagonist), and LPS (5 mg/L)+vehicle (DMSO 0.2 ml/L). The expressions of CD40 and ICAM-1 RNA in RPMCs were examined by RT-PCR after 3 hour treatment, and the protein expressions of CD40, ICAM-1, p-NF-κB p65 and p-IκBα were examined by Western blot or immunofluorescence after 24 hour treatment. Results Following treatment with LPS, both the expressions of CD40 and ICAM-1 protein in RPMCs were up-regulated significantly (P<0.05), and the phosphoralation of p65 was increased greatly (1.10±0.17 vs 0.55±0.06, P<0.05). BAY11-7085 (5 μmol/L) significantly decreased the protein expression of p-p65 (0.22±0.11 vs 1.10±0.17, P<0.01), CD40 (0.34±0.02 vs 0.50±0.06, P<0.05) and ICAM-1 (0.35±0.16 vs 0.74±0.03, P<0.05). Pretreated with rosiglitazone for 3 h then added with LPS for 1 h, the levels of p-p65, CD40 and ICAM-1 in RPMCs were significantly decreased compared with those of LPS group (0.77±0.08 vs 0.90±0.10, P相似文献