败酱皂甙及其皂甙元的一般药理作用

本文对败酱皂甙及其甙元的一般药理作用进行了研究。败酱皂甙是败酱(Patrinia scabiosal-folid)中的主要成份,其他败酱属植物中同样含有败酱皂甙。败酱皂甙是十一位碳上的羟基结合葡萄糖的环烯醚萜甙类化合物。败酱皂甙不同给药途径的LD_(50)分别为595毫克/公斤(静注)、350毫克/公斤(皮下)、555毫克/公斤(腹腔)、2克/公斤(口服)。其皂甙元的LD_(50)分别为143毫克/公斤(静注)、234毫克/公斤(皮下)、182     

雪蛤参茸蜂王浆强壮作用的研究

雪蛤参茸蜂王浆有明显的抗疲劳、抗缺氧和抗低温作用。显著增强正常、特别是免疫功能低下小鼠单核—巨噬细胞系统吞噬功能;促使正常小鼠脾、胸腺增大,并能对抗环磷酰胺所致的二者萎缩及白细胞下降;明显提高血清溶血素含量,增强DNCB引起的迟发型超敏反应。对正常幼鼠生长和雄性小鼠睾丸、附性器官发育也有显著的促进作用。     

THE ANTI-ALLERGIC INFLAMMATION ACTION OF SAIKOSAPONINS

Saikosaponins had marked suppressive ef-fect upon allergic inflammation,such as PCAreaction,Arthus reaction,adjuvant arthritis anddelayed hypersensitiveness.It had no obviouseffect on the antibody titre level and the amountof immune complexes in the serum of experi-mental rats in Arthus reaction or on the pha-gocytosis of the reticuloendothelial system ofexperimental mice.Saikosaponins solution did,however,decrease the leucocyte count and theamount of histamine and PGE in the inflamma-tory exudates of the Arthus reaction and blockthe release of histamine.Experimental resultsindicated that the suppressive action of Saikosa-ponins on allergic inflammation was due mainlyto the suppression of the synthesis,release andaction of inflammatory mediators such as his-famine,PGE and 5-HT of the inflammatoryprocess in the later stage of allergic reaction.No obvious effect on the humoral and cellularimmunity was noted.