华蟾素胶囊联合TN化疗方案对中晚期宫颈癌放疗患者血清SCC、TSGF水平及生存质量的影响

目的:探讨华蟾素胶囊联合TN化疗方案(紫杉醇+奈达铂)在中晚期宫颈癌放疗患者中的应用效果。方法:选取中晚期宫颈癌放疗患者71例,按照随机数字表法分组,对照组35例给予TN化疗方案治疗,观察组36例给予TN化疗方案+华蟾素胶囊治疗,观察比较两组临床疗效及治疗前后血清鳞状细胞癌相关抗原（SCC）、肿瘤特异性生长因子（TSGF）水平及生存质量各维度评分变化情况,并统计两组毒副反应发生情况及1年、2年、3年生存率。结果:观察组临床缓解率为83.33%（30/36）,高于对照组57.14%（20/35）（P＜0.05）;治疗4个疗程后观察组血清SCC、TSGF水平低于对照组（P＜0.05）;观察组便秘、腹泻及恶心呕吐发生率与对照组比较,差异无统计学意义（P＞0.05）;观察组白细胞下降发生率为11.11%（4/36）,低于对照组31.43%（11/35）（P＜0.05）;治疗4个疗程后观察组认知、角色、躯体、社会及情绪功能生存质量评分高于对照组（P＜0.05）;观察组1年生存率为91.67%（33/36）、2年生存率为86.11%（31/36）、3年生存率为77.78%（28/36）,与对照组（91.43%、85.71%、74.29%）比较,差异无统计学意义（P＞0.05）。结论:TN化疗方案联合华蟾素胶囊可降低中晚期宫颈癌放疗患者血清TSGF、SCC水平,提高其生存质量,疗效确切,安全性高。     

血清TSGF、CA125与CEA联合测定对卵巢癌的早期诊断价值

探讨肿瘤相关物质(TSGF)、糖类抗原125(CA125)及CEA联合测定在卵巢癌早期诊断中的应用价值.对85例卵巢癌组、54例良性肿瘤组患者及76名对照组分别检测TSGF、CA125和CEA.结果显示:卵巢癌组与良性肿瘤组和对照组相比,三项标志物的血清含量有显著性差异(P＜0.05).检测阳性率、敏感性、特异性、准确度、阳性预测值和阴性预测值六个方面,联合检测均优于单项检测,提示血清TSGF、CA125与CEA联合测定对卵巢癌的早、中期诊断具有一定应用价值.     

原发性肝癌患者血清CA199和TSGF联检的临床意义

目的:探讨了原发性肝癌患者血清TSGF和CA199水平的变化及其临床意义。方法:应用免放法测定33例原发性肝癌患者血清CA199含量,光电比色法测定TSGF含量,并与35名正常健康人作比较。结果:原发性肝癌患者血清TSGF和CA199水平均非常显著地高于正常人组(P<0.01)且与血清AFP水平呈明显的正相关。结论:测定原发性肝癌患者血清TSGF和CA199水平对临床的诊断和治疗均有十分重要的临床价值。     

肺癌患者血清中CA125、CEA、TSGF联合检测的临床意义

目的探讨肺癌患者血清中CA125、CEA、TSGF联合检测的临床意义。方法抽取空腹静脉血2mL,4000r/min下离心10min。采用2010型电化学发光全自动免疫分析仪及试剂进行CA125、CEA、TSGF检测。结果肺癌组血清CA125、CEA、TSGF的表达水平分别显著高于肺部感染组和健康对照组,经统计学分析,有显著性差异(P0.05)。CA125、CEA、TSGF单独及联合检测的特异性、敏感性不同,其中CA125、CEA、TSGF联合检测的灵敏度为最高,达到93.3%。结论CA125、CEA、TSGF联合检测为肺癌的临床诊断、治疗提供了可靠的依据,值得临床广泛应用。     

恶性胸腹水TSGF和CEA联合检测的临床评价

0 引言 恶性肿瘤特异性生长因子(TSGF)被认为是在肿瘤血管发生中起重要作用的内源性血管发生因子,目前将其作为非器官特异性肿瘤标志物用于恶性肿瘤的辅助诊断.我们应用TSGF和癌胚抗原(CEA)联合检测胸腹水,观察其对良、恶性胸腹水的临床鉴别诊断价值.     

Expression and Significance of TSGF,CEA and AFP in Patients Before and after Radical Surgery for Colon Cancer

Objective: To explore the expression and significance of tumor specific growth factor (TSGF), carcinoembryonicantigen (CEA) and alpha fetoprotein (AFP) in cancer tissue and serum of patients with colon cancer. Materialsand Methods: Radical surgery for colon cancer was performed on 43 patients with laparoscopu under conditionsof general anesthesia. The Elisa method was used to detect the levels of serum TSGF, CEA and AFP before andafter radical operation, and cancer tissue underwent TSGF, CEA and AFP immunohistochemistry staining afterlaparoscopic surgery. The decreased conditions of serum TSGF, CEA and AFP in patients with colon cancer atdifferent levels of differentiation and clinical stagings were analyzed, and the relationships of expression ratesbetween histological types, colon cancer morphology, lymph node metastasis and TSGF, CEA as well as AFPin cancer tissue were assessed. Results: Compared with before radical surgery, the levels of serum TSGF, CEAand AFP decreased notably in patients after operations (p<0.01). The decreased degree of TSGF and CEA wasthe largest in patients with poorly differentiated cancer tissue (p<0.01), while that of AFP was noted in patientswith moderately differentiated cancer tissue (p<0.01). The decreased degree of TSGF and AFP was the largestin patients at phase Dukes A (p<0.01), while that of CEA in patients at phase Dukes C (p<0.01). There were nosignificant differences among the positive expression rates of TSGF, CEA and AFP with different histologicaltypes and colon cancer morphologies (p>0.05). The positive expression rates of TSGF and CEA in patients withlymph node metastasis were significantly higher than those without lymph node metastasis (p<0.01). Conclusions:TSGF, CEA and AFP can be used to evaluate the effect of radical operation for colon cancer, and the changedlevels of different markers are associated with tumor differentiation, clinical stating and presence or absence oflymph node metastasis.     

胰腺癌患者血清TSGF和CA199联合检测的临床意义

目的探讨胰腺癌患者血清恶性肿瘤相关物质群(TSGF)和糖类抗原199(CA199)水平的变化及其临床意义。方法应用放免法测定33例胰腺癌血清CA199含量,光电比色法测定TSGF含量,并与35名正常健康人作比较。结果胰腺癌患者血清TSGF和CA199水平均非常显著地高于正常人组(P<0.01),且与血清甲胎蛋白(AFP)水平呈明显的正相关。结论测定胰腺癌患者血清TSGF和CA199水平对临床的诊断和治疗均有十分重要的临床价值。     

血清联检TSGF、CEA、SA诊断肺癌的价值

目的观察肺癌患者血清恶性肿瘤特异性生长因子(TSGF)、癌胚抗原(CEA)、唾液酸(SA)含量变化 ,探讨其在肺癌诊断中的价值。方法用生化比色定量法检测TSGF、SA ,用放射免疫法检测CEA。结果肺癌组TSGF、CEA、SA血清水平分别为(82.9±20.5)KU/L、(33.8±19.5)μg/L、(750.7±172.3)mg/L ,显著高于肺良性疾病组和健康对照组(P<0.001)。三者联合检测则诊断阳性率高达100 %。结论TSGF、CEA、SA检测在肺癌诊断中均有意义 ,三项联合检测则具有更重要的诊断价值 ,并可提高其诊断的敏感性和准确性。     

食管上皮癌变过程的恶性肿瘤特异性生长因子测定

目的：观察食管上皮癌变过程中ＴＳＧＦ（恶性肿瘤特异性生长因子）的变化,验证ＴＳＧＦ对早期食管癌的检测能力。方法：双盲测定食管上皮癌变不同阶段人群ＴＳＧＦ水平;实验数据使用ＳＡＳ软件拟合（ＧＬＭ）过程,用最小显著差法进行分析。结果：食管上皮病变组（食管上皮重度增生、原位癌及中、晚期癌）的ＴＳＧＦ水平均高于正常组,（Ｐ〈０．０５）。在癌变过程中,ＴＳＧＦ水平逐渐增高,至癌前病变达到最高值;当癌前病变发     

血清TSGF、HIF-1α在皮肤鳞状细胞癌中的表达及意义

目的探讨血清TSGF、HIF-1α在皮肤鳞状细胞癌的表达情况及其意义。方法选取90例皮肤鳞状细胞癌患者为观察组,选取同时期的90名体检健康者为对照组,检测与比较两组的血清TSGF、HIF-1α水平及阳性率,同时比较观察组中不同分级、分化程度及病灶部位患者的血清TSGF、HIF-1α水平及阳性率,并采用Logistic回归分析血清TSGF、HIF-1α水平与皮肤鳞状细胞癌的关系。结果观察组的血清TSGF、HIF-1α水平及阳性率均高于对照组,分级较高及分化程度较低的患者血清TSGF、HIF-1α水平及阳性率均高于分级较低及分化程度较高的患者,而不同病灶部位患者的血清TSGF、HIF-1α水平及阳性率差异则无统计学意义,经Logistic回归分析处理显示,血清TSGF、HIF-1α水平均与皮肤鳞状细胞癌有密切的关系。结论血清TSGF、HIF-1α水平在皮肤鳞状细胞癌患者中呈现高表达状态,且上述血清指标对于本病的分级及分化程度均有一定的指导意义,因此在皮肤鳞状细胞癌患者中具有较高的检测价值。