影响电针镇痛因素的实验研究概况

本文介绍了有关影响电针镇痛因素的实验研究概况。多数资料表明,电针刺激的强度、频率以及所选择的穴位和时辰不同可产生不同的镇痛作用;不同参数电针刺激的镇痛效应有不同的神经生理和神经生物化学机制。     

Effects of Moxibustion Pretreating on SOD and MDA in the Rat of Global Brain Ischemia

objective;To probe into the mechanism of moxibustion preconditioning in preventive brain-protecting effect.Methods;The global brain ischemia rat model was developed by blocking 4 artenes.Seventy-eight Wistarmale rats were randomly divided into 5 groups;a nomal control group,a sham-operation group,a brain ischemia group,a brain ischemia preconditioning group,a moxibustion pretreating group.The brains in the 5groups were taken at 24 h,48h,and 72h after operation respectively Superoxide dismulase(SOD)activity was determined with xanthine oxidase method and malondialdehyde(MDA)content with thiobarbituric acid method.Results;After the operation,in the moxibustion preconditioning group,SOD activity significantly increased,especially 24h after moxibustion preconditioning;and MDA content decreased,with a very significant difference as compared with that of the cerebral ischemia group(P＜0.01).Conclusion;Moxibustion preconditioning protects the ischemic and anoxic brain tissue by increasing the activity of endogenous antioxidase.     

不同电针刺激强度和频率对大鼠脑内单胺类神经介质有不同的影响

比较了两种不同电针刺激强度(负载电压峰-峰值3伏,6伏)和频率(10赫兹,200赫兹)对大鼠不同脑区内5-羟色胺(5-HT)及其代谢产物5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NA)和多巴胺(DA)水平的影响。70只体重为250克左右的健康雄性大鼠随机分为五个实验组:Ⅰ对照组,Ⅱ低     

A Multicentral Randomized Control Study on Clinical Acupuncture Treatment of Bell＇s Palsy

To confirm the clinical therapeutic effects of acupuncture and moxibustion on Bell＇s palsy. Methods： 480 cases from 4 hospitals were enrolled for this study, among whom 439 cases completed the whole course of the study. The patients were randomly divided into the following 3 groups, a control group（treated with prednisone, vitamin B 1, vitamin B 12 and dibazol）, an acu-moxibustion group （treated with filiform needle plus moxibustion）, and a basic treatment plus acu-moxibustion group （treated with oral medicine like those in the control group plus acupuncture, and with moxibustion like in the acu-moxibustion group）. The whole treatment course lasted 4 weeks. The therapeutic effects were evaluated according to the symptoms and signs, House-Brackmann grading scale and facial disability indexes（FDI）. Results： All the 4 centers （hospitals） completed this study well, with no statistically significant difference found among the 4 centers in therapeutic effects. The patients with different conditions were well distributed in the 3 groups, thus the basic general data were comparable （P〉0.05）. The therapeutic effects of the two treatment groups were better than the control group （respectively P〈0.05 and P〈0.01）, and it was the best in the acu-moxibustion group （P〈0.01）. Conclusion： Acupuncture and moxibustion may exert definite therapeutic effects on Bell＇s palsy, better than that of the basic treatment group or the basic treatment plus acu-moxibustion group.     

THE ROLE OF ACETYLCHOLINE IN THE RAT BRAIN AND ITS EFFECT ON 5-HYDROXYTRYPTAMINE METABOLISM DURING ELECTROACUPUNCTURE ANALGESIA

After electroacupuncture (EA) for 25 minutes stthe bilateral Shousanli (LI 10) and Huantiao (GB30) points of rats,5-hydroxytryptamine (5-HT) con-tents in medulla oblongata plus pons and midbrainmarkedly increased with elevation of pain threshold.However,preliminary intraperitoneal injection of at-ropine,a muscarinic receptor inhibitor of acetylcho-line,not only partially blocked the effect of electroa-cupuncture analgesia (EAA),but also abolished theincrease of 5-HT in the brain.These results suggest that the cholinergic systemmay play an important role in EAA,which may bemediated through the central serotonergic system inthe brain.     

大鼠腹腔注射纳洛酮对电针镇痛效应及其脑内儿茶酚胺含量变化的影响

<正> 中枢儿茶酚胺(CA)主要有去甲肾上腺素(NA)和(DA)。我们曾观察到电针后大鼠脑内 NA 和 DA 含量发生显著变化,这种效应与所用的电针频率和强度有密切关系。许多实验研究也支持 NA 和 DA参与针刺镇痛过程。此外,阿片受体拮抗剂纳洛酮广泛被用来间接检查某一生理过程是否有内源性吗啡样物质参与。大量实验表明,无论全身性或脑室注射纳洛酮可以阻断或降低针刺的效应。由于脑内多种神经化学物质在代谢和功能上有着密切的联系。在本工作中,我们观察了大鼠腹腔注射纳洛酮对电针镇痛效应及其脑内 NA 和 DA 含量变化的影响,以便探讨阿片受体在针刺镇痛中对中枢 CA 的调节作用。     

Acupuncture Treatment for 57 Cases of Hiccup

In recent years,the author has treated 57 casesof hiccup due to radiotherapy,chemotherapy orintroducing therapy by acupuncture with satisfactoryresults as reported in the following.     

两种不同电针刺激强度和频率对大鼠脑内单胺类神经介质影响的比较

<正> 目前针刺临床和针刺原理研究中常常采用电针代替手法捻针,因此,电针刺激参数成为针刺临床和针刺原理研究中的一个基本重要研究问题。这方面的研究对阐明针刺原理和提高针刺治疗效果将是非常必要的。电针刺激参数包括波形、波幅、波宽、频率、节律和持续时间等。本文比较了两种不同电针刺激强度和频率对大鼠不同脑区内5-羟色胺(5-HT)、5-羟吲哚乙酸(5-HIAA)、去甲肾上腺素(NA)和多巴胺(DA)水平的影响。     

电针和电刺激猫皮层SⅡ区对血浆皮质醇含量的影响

电针穴位、电刺激皮层ＳⅡ区及电针＋电刺激ＳⅡ区对猫血浆皮质醇含量的影响是相似的，提示可能有某种共同的中枢机制参与电针和电刺激ＳⅡ区对肾上腺皮质功能的调节。ＳⅡ区也可能参与电针的这种调节作用。