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T. V. Kochikyan M. A. Samvelyan E. V. Arutyunyan V. S. Arutyunyan A. A. Avetisyan M. G. Malakyan L. A. Vardevanyan S. A. Badzhinyan 《Pharmaceutical Chemistry Journal》2011,44(10):525-527
A series of new derivatives of 1,2,4-triazoles have been synthesized and their antioxidant properties have been studied. It
was established that the obtained compounds exhibit a stabilizing effect on cell membranes and demonstrate antioxidant activity
with respect to erythrocytes under oxidative stress conditions. 相似文献
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TB Bukharova IV Arutyunyan SA Shustrov IS Alekseeva IA Fedyunina LV Logovskaya AV Volkov AA Rzhaninova AS Grigor'yan AA Kulakov DV Gol'dshtein 《Bulletin of experimental biology and medicine》2011,152(1):153-158
We developed a new method of creation of tissue engineering constructs for regeneration of the bone tissue based on the principle of free distribution of cells in a fibrin clot within a scaffold. The tissue engineering construct includes multipotent stromal adipose tissue cells committed in osteogenic lineage, platelet-rich plasma, and resorbed material on the basis of xenogeneic bone collagen. The culture of bone progenitor cells was characterized by the main markers of osteoblastic differon. The material meets all requirements for materials intended for tissue engineering. An innovative high-technological tissue engineering product for clinical application is prepared. 相似文献
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One more probable structural transition in potato virus X virions and a revised model of the virus coat protein structure 总被引:1,自引:0,他引:1
Nemykh MA Efimov AV Novikov VK Orlov VN Arutyunyan AM Drachev VA Lukashina EV Baratova LA Dobrov EN 《Virology》2008,373(1):61-71
We found that a 2-h incubation of potato virus X (PVX) virions in 10 mM Tris-HCl buffer pH 7.5 at -20 degrees C results in a strong but reversible drop in virion stability. Under these conditions, the PVX virions are completely disrupted by low (starting from 50 mM) concentrations of LiCl and CaCl(2) but not of NaCl. Incubation of PVX samples with 0.05-2 M LiCl at +4 degrees C did not result in virion disassembly and the virions were not disrupted upon incubation at -20 degrees C in 10 mM Tris-HCl buffer pH 7.5 without LiCl. We suggest that a 2-h incubation of the PVX virions at -20 degrees C in 10 mM Tris-HCl pH 7.5 results in a structural transition in the virus particles. A revised model of the three-dimensional organization of coat protein subunits in the PVX virions is proposed. This two-domain model explains better the high plasticity of the PVX CP structure. 相似文献
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