A comparative study of the fixation of antibiotics of the tetracycline group by homogenates of organs

Summary The authors established the quantitative fixation of chlortetracycline, tetracycline, and oxytetracycline by homogenates of the liver, kidneys, spleen, lungs, heart, and brain of white rats. Fixation by the organ homogenates was greatest by chlortetracycline, followed by tetracycline and oxytetracycline in that order. Homogenates of the liver, kidneys, and brain fixed the tetracyclines in considerable quantitities, those of the lungs, heart and spleen—to a noticeably lesser degree.Presneted by Active Member AMN SSSR V. V. Zakusov     

The effect of single and repeated doses of tetracyclines on the phagocytic function of the reticulo-endothelial system

Summary As distinct from single administration of antibiotics belonging to the tetracycline group, repeated doses of these antibiotics did not stimulate the phagocytic function of the reticuloendothelial system; the latter was depressed or not affected. The most intensive action on the reticuloendothelial system is produced by chlortetracycline, then by oxytetracycline, and the least by tetracycline.The results were assessed by recording the number of colonies ofStaphylococcus aureus cultivated from the blood of mice into which this microorganism was injected intravenously.Presented by Active Member AMN SSSR V. V. Zakusov Translated from Byulleten' Éksperimental'noi Biologii i Meditsiny, Vol. 55, No. 5, pp. 84–87, May, 1963