不同敷料组合对烧伤患者供皮区创面微环境的影响

Objective To investigate the effect of dressing materials in various combinations on bum wound microenvironment and healing condition. Methods Two hundred donor sites with wounds of 0.3 mm in depth in 186 burn patients, who needed skingrafting and admitted to our ward were enrolled in study, and they were divided into A ( with dressing composed of aiginate + cotton pad for donor area), B ( with dressing composed of vaseline gauze + cotton pad for donor area) , C (with dressing composed of algi-nate+ foam dressing for donor area), D ( with dressing composed of vaseline gauze + foam dressing for donor area) groups according to random table method. Effect of dressings on wound evaporation and pH value were observed. Bacterial colonization, degree of pain complained by patients after dressing change, and wound healing time in each group were compared. Results One hundred and eighty-four patients complied with the study, while 2 patients were excluded due to untimely falling-off of the dressing. Wound evaporaton in respectively, among them B group showed optimal effect of keeping humidity (P<0.01). Wound pH value in A, B, C, D groups was 7.22±0.06, 7.41±0.03, 7.05±0.03, 7.34±0.06, respectively, among them it was highest in B group. The positive rate of bacteria in D group was highest (22.4%), and lowest in C group (4.0%). Pain was lightest in C group (score was 0.98±0.12), and most serious in B group ( score was 8.14±0.82). The shortest wound healing time was seen in C group (6.7±0.8 d) , and longest in D group (15.6±3.5 d). Conclusions Application of various dressings on similar wounds can pro-duce different wound microenvironment, which is closely related to wound healing time. Compared with pH value, humidity is the more important factor for wound healing.     

Pfizer／大正确定精神分裂症项目

Pfizer和日本大正公司已经达成一项最终转让协议，把大正治疗精神分裂症的代谢性谷氨酸（mGlu）激动剂TS-032，除日本外的全球权利转让给了Pfizer。Pfizer将独家开发这种临床前化合物并使其商业化。其他致力于mGlu领域的公司还有Lilly，它已经报道其候选药LY2140023的Ⅱ期试验阳性数据。     

Bioxell寻找elocalcitol的后期伙伴

意大利Bioxell生物技术公司在准备实施其领先候选产品elocalcitol（I）的Ⅱ期试验的同时寻找其开发和商品化伙伴。     

不同敷料组合对烧伤患者供皮区创面微环境的影响

Objective To investigate the effect of dressing materials in various combinations on bum wound microenvironment and healing condition. Methods Two hundred donor sites with wounds of 0.3 mm in depth in 186 burn patients, who needed skingrafting and admitted to our ward were enrolled in study, and they were divided into A ( with dressing composed of aiginate + cotton pad for donor area), B ( with dressing composed of vaseline gauze + cotton pad for donor area) , C (with dressing composed of algi-nate+ foam dressing for donor area), D ( with dressing composed of vaseline gauze + foam dressing for donor area) groups according to random table method. Effect of dressings on wound evaporation and pH value were observed. Bacterial colonization, degree of pain complained by patients after dressing change, and wound healing time in each group were compared. Results One hundred and eighty-four patients complied with the study, while 2 patients were excluded due to untimely falling-off of the dressing. Wound evaporaton in respectively, among them B group showed optimal effect of keeping humidity (P<0.01). Wound pH value in A, B, C, D groups was 7.22±0.06, 7.41±0.03, 7.05±0.03, 7.34±0.06, respectively, among them it was highest in B group. The positive rate of bacteria in D group was highest (22.4%), and lowest in C group (4.0%). Pain was lightest in C group (score was 0.98±0.12), and most serious in B group ( score was 8.14±0.82). The shortest wound healing time was seen in C group (6.7±0.8 d) , and longest in D group (15.6±3.5 d). Conclusions Application of various dressings on similar wounds can pro-duce different wound microenvironment, which is closely related to wound healing time. Compared with pH value, humidity is the more important factor for wound healing.     

Sepraor／Bial签订抗癫痫药项目

Sepraor公司和Bial公司已达成在北美开发并商业化抗癫痫化合物BIA2—093（eslicarbazepine acetate）（Ⅰ）的协议。（Ⅰ）是一种钠通道拮抗剂，已经在22个国家进行了3项Ⅲ期临床试验。这些试验包括1000多例患者为期18周的急性双盲治疗，以及此后的1年标签公开的后续研究。     

Schering—Plough的sugammadex获得优先审核

美国FDA给了Schering—Plough公司的新型选择性肌松结合药Sugammadex（sugammadex sodium）优先审核地位。公司希望能够在今年第二季度得到FDA的决定。申请的依据是1700多名患者参加的10项全球性Ⅲ期试验，与向EU申请的文件是相同的。EMEA在去年7月已接受该药进行审核。Schering—Plough在11月收购Organon Biosciences时得到该产品。     

青海省藏族人群乙型肝炎病毒感染者基因型及基因突变的观察

乙型肝炎病毒(HBV)在青海省藏族人群的感染较为严重,经多次血清学调查,同德地区为该人群中乙型肝炎高流行区,对其HBV的基因型等基本状态的分析,有助于对该人群的乙型肝炎防制提供策略.     

首个治疗PKU的药物在欧洲申请

Merck Serono向EMEA申请了治疗苯丙酮尿症（PKU）的药物sapropterin（过去称phenoptin，沙丙蝶呤）（I）的许可证，使该药更接近成为欧洲第一个批准治疗PKU的药物。2007年5月Merck Serono的开发伙伴Biomarin在美国同样提出申请。     

Cephalon在美申请Treanda治疗NHL

Cephalon公司已向美国FDA申请其抗肿瘤药Treanda（bendamustine HCl，盐酸苯达莫司汀，从Astellas公司转让）（Ⅰ）的第二适应症——非霍奇金淋巴瘤（NHL）。     

脊髓粘液乳头型室管膜瘤的显微手术治疗（附18例报道）

目的 探讨脊髓粘液乳头型室管膜瘤（MPE）临床特点及显微手术治疗的疗效。方法 回顾性分析2013年1月至2020年1月手术治疗并经病理证的18例脊髓MPE的临床资料。结果 腰痛是最常见首诊症状,其次为大小便功能异常、运动功能障碍及感觉异常;病程2周~20年,平均33.3个月。18例共行28次手术,3例行3次手术,4例行2次手术;首次手术肿瘤全切除6例,非全切除12例;肿瘤全切除率为33.33%。术后随访2个月~7年,平均33.2个月,死亡1例,年总生存率达95.8%;首次术后复发8例,1、2年复发率为5.56%、33.33%,总复发率为44.44%。末次随访,McCormick分级Ⅰ级4例,Ⅱ级2例,Ⅲ级11例,Ⅳ级1例;术后神经功能改善6例,恶化12例。结论 显微手术是脊髓MPE首选治疗方法,首次手术未全切除肿瘤,易出现肿瘤复发,早诊断、早治疗不仅有助于延长病人生存期,也有利于提高病人术后生活质量。