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11.
Weixia Zhong Omar Shahbaz Garrett Teskey Abrianna Beever Nala Kachour Vishwanath Venketaraman Nissar A. Darmani 《International journal of molecular sciences》2021,22(11)
Nausea and vomiting are common gastrointestinal complaints that can be triggered by diverse emetic stimuli through central and/or peripheral nervous systems. Both nausea and vomiting are considered as defense mechanisms when threatening toxins/drugs/bacteria/viruses/fungi enter the body either via the enteral (e.g., the gastrointestinal tract) or parenteral routes, including the blood, skin, and respiratory systems. While vomiting is the act of forceful removal of gastrointestinal contents, nausea is believed to be a subjective sensation that is more difficult to study in nonhuman species. In this review, the authors discuss the anatomical structures, neurotransmitters/mediators, and corresponding receptors, as well as intracellular emetic signaling pathways involved in the processes of nausea and vomiting in diverse animal models as well as humans. While blockade of emetic receptors in the prevention of vomiting is fairly well understood, the potential of new classes of antiemetics altering postreceptor signal transduction mechanisms is currently evolving, which is also reviewed. Finally, future directions within the field will be discussed in terms of important questions that remain to be resolved and advances in technology that may help provide potential answers. 相似文献
12.
Kazadi N. Mutoji Mingxia Sun Garrett Elliott Isabel Y. Moreno Clare Hughes Tarsis F. Gesteira Vivien J. Coulson-Thomas 《International journal of molecular sciences》2021,22(11)
Corneal transparency relies on the precise arrangement and orientation of collagen fibrils, made of mostly Type I and V collagen fibrils and proteoglycans (PGs). PGs are essential for correct collagen fibrillogenesis and maintaining corneal homeostasis. We investigated the spatial and temporal distribution of glycosaminoglycans (GAGs) and PGs after a chemical injury. The chemical composition of chondroitin sulfate (CS)/dermatan sulfate (DS) and heparan sulfate (HS) were characterized in mouse corneas 5 and 14 days after alkali burn (AB), and compared to uninjured corneas. The expression profile and corneal distribution of CS/DSPGs and keratan sulfate (KS) PGs were also analyzed. We found a significant overall increase in CS after AB, with an increase in sulfated forms of CS and a decrease in lesser sulfated forms of CS. Expression of the CSPGs biglycan and versican was increased after AB, while decorin expression was decreased. We also found an increase in KS expression 14 days after AB, with an increase in lumican and mimecan expression, and a decrease in keratocan expression. No significant changes in HS composition were noted after AB. Taken together, our study reveals significant changes in the composition of the extracellular matrix following a corneal chemical injury. 相似文献
13.
Garrett BC Dixon DA Camaioni DM Chipman DM Johnson MA Jonah CD Kimmel GA Miller JH Rescigno TN Rossky PJ Xantheas SS Colson SD Laufer AH Ray D Barbara PF Bartels DM Becker KH Bowen KH Bradforth SE Carmichael I Coe JV Corrales LR Cowin JP Dupuis M Eisenthal KB Franz JA Gutowski MS Jordan KD Kay BD Laverne JA Lymar SV Madey TE McCurdy CW Meisel D Mukamel S Nilsson AR Orlando TM Petrik NG Pimblott SM Rustad JR Schenter GK Singer SJ Tokmakoff A Wang LS Wettig C Zwier TS 《Chemical reviews》2005,105(1):355-390
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Driving a Wedge Between Evidence and Beliefs: How Online Ideological News Exposure Promotes Political Misperceptions 下载免费PDF全文
R. Kelly Garrett Brian E. Weeks Rachel L. Neo 《Journal of Computer-Mediated Communication》2016,21(5):331-348
This article has 2 goals: to provide additional evidence that exposure to ideological online news media contributes to political misperceptions, and to test 3 forms this media‐effect might take. Analyses are based on representative survey data collected during the 2012 U.S. presidential election (N = 1,004). Panel data offer persuasive evidence that biased news site use promotes inaccurate beliefs, while cross‐sectional data provide insight into the nature of these effects. There is no evidence that exposure to ideological media reduces awareness of politically unfavorable evidence, though in some circumstances biased media do promote misunderstandings of it. The strongest and most consistent influence of ideological media exposure is to encourage inaccurate beliefs regardless of what consumers know of the evidence. 相似文献
16.
Ali Hashmi Garrett Heiman Gan Yu Mark Lewis Hyuck-Jin Kwon Jie Xu 《Microfluidics and nanofluidics》2013,14(3-4):591-596
Microstreaming generated from oscillating microbubbles has great potential in microfluidic applications for localized flow control. In this study, we explore the use of teardrop-shaped cavities for trapping microbubbles. Upon acoustic actuation, these microbubbles confined in teardrop cavities can be utilized to generate a directional microstreaming flow. We further show that by altering the acoustic excitation frequency, a flow-switch for altering flow direction in microfluidic environments can be achieved using two oppositely arranged teardrop cavities with different sizes. In the end, we show that an array of such bubble-filled teardrop cavities can act as a fixated microfluidic transport system allowing for on-chip particle manipulation in complex flow patterns. This inexpensive method to create flows to switch and transport elements based on teardrop cavities can be widely employed for microfluidic applications such as drug delivery systems. 相似文献
17.
Single channel currents were activated by GABA (0.5 to 5 microM) in cell-attached and inside-out patches from cells in the dentate gyrus of rat hippocampal slices. The currents reversed at the chloride equilibrium potential and were blocked by bicuculline (100 microM). Several different kinds of channel were seen: high conductance and low conductance, rectifying and "nonrectifying." Channels had multiple conductance states. The open probability (Po) of channels was greater at depolarized than at hyperpolarized potentials and the relationship between Po and potential could be fitted with a Boltzmann equation with equivalent valency (z) of 1. The combination of outward rectification and potential-dependent open probability gave very little chloride current at hyperpolarized potentials but steeply increasing current with depolarization, useful properties for a tonic inhibitory mechanism. 相似文献
18.
Antony Jan Benjamin A. Reeves Yoeri van de Burgt Garrett J. Hayes Bruce M. Clemens 《Advanced Engineering Materials》2018,20(1)
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Milliken Garrett W.; Ferra Gina; Kraiter Kyle S.; Ross Courtney L. 《Canadian Metallurgical Quarterly》2005,119(4):430
Sixteen sifakas (11 Propithecus verreauxi coquereli, 2 Propithecus verreauxi verreauxi form majori, and 3 Propithecus tattersalli) were videotaped as they fed on leaves in an arboreal context. The hand used to feed and the hand used to maintain postural stability was coded. For each subject, the lateral bias of the hand used to feed was opposite the hand used in postural support. Seven sifakas displayed no bias for feeding or posture-related hand use, 7 sifakas displayed significant feeding-related reach preferences for pulling branches to the mouth (5 left- and 2 right-hand preferences), and 9 sifakas exhibited significant hand preferences for postural support (2 left-, 7 right-hand preferent). Although these data do not strongly support the postural origins theory of behavioral lateralization, the modal preference pattern for sifakas that displayed significant hand preferences for posture and feeding involve a left bias for feeding and a right bias for postural support. (PsycINFO Database Record (c) 2010 APA, all rights reserved) 相似文献