27例乙型血友病患者Ⅸ因子基因突变研究

采用ＰＣＲ（聚合酶链反应）及ＧＡＷＴＳ（ＧｅｎｏｍｉｃＡｍｐｌｉｆｉｃａｔｉｏｎｗｉｔｈＴｒａｎｓｃｒｉｐｔｓＳｅｑｕｅｎｃｉｎｇ）技术，研究了江苏、湖北、山东、广东、福建、宁夏六省区２７例乙型血友病患者及其家系成员ＦⅨ（九因子）基因各２．２Ｋｂ　ＤＮＡ序列。在２ｌ例中发现２０种不同类型的突变。其中１２种是未曾报道的新突变。３８％的突变发生在ＣｐＧ二核苷致序列上，进一步证实了ＣｐＧ确系突变热点。同时检出６例女性为致病基因携带者。对开展基因产前诊断及优生优育等，具有重要意义。     

EXPERIMENTAL STUDIES AND NUMERICAL CALCULATION ON TURBULENT BOUNDARY LAYER OF WATER FLOW ALONG CURVED SURFACE

This paper will introduce experimental studies and numerical calculation onturbulent boundary layer of water flow along curved surface in our country in recent years.Onthe basis of the experimental studies,the effects of curvature and roughness on velocitydistribution and pressure distribution and the change of turbulent flow boundary layer onoverflow bucket concave surface is discussed.We proposed the empirical formula of velocity,pressure and the change of turbulent flow boundary layer on outlet bucket concave.According tothe momentum principle,we have deduced the momentum integral equation full water depthboundary layer and using the element as control unit inside the boundary layer on concavesurface of bucket.Combining with continuity equation,we have computed the boundary layerdevelopment on the bucket of a spillway.Compared with the field experimental data,thecalculation results are available.Under polar coordinates,a mathematical model for simulatingtime-averaged flow characteristics in concave surface of bucket is established.The turbulent flowfield on concave surface of bucket is calculated by SIMPLE method and this mathematicalmodel.The flow velocity field,pressure field,distribution of turbulent kinetic energy,distribution of turbulent energy dissipating rate and distribution of shear stress are available.Thecalculation value is consistent with measured test data.     

激光加热在Al2O3/Ti系梯度功能材料制备过程中的作用及机理

梯度功能材料是一种界面连续化的新型复合材料,本文研究了激光加热在合成Al2O3/Ti系梯度功能材料过程中的作用和机理,同时用激光大光斑加热方法制备出直径11mm厚度3mm完整的FGM试样并加以分析,以及首次采用在试样中埋设微细热电偶成功地测出了激光加热造成的温度梯度分布。     

饱和—非饱和土体非稳定渗流数值分析

本文对一般的非饱和渗流有限元计算方法加以改进，有效地消除了非饱和渗流数值计算中存在的数值弥散现象。同时还提出了一种简便有效的逸出面处理新方法，并给出了非饱和非稳定渗流计算的实例。     

Moving Endpoints and the Internal Consistency of Agents' Ex Ante Forecasts

Forecasts by rational agents contain embedded initial and terminal boundary conditions. Standard time series models generate two types of long-run boundary values or steady-state 'endpoints' – fixed endpoints and moving average endpoints. Neither can explain the shifting endpoints implied by postwar movements in the cross-section of forward rate forecasts in the term structure or by post-1979 changes in survey estimates of expected long-run inflation. Multiperiod forecasts by a broader class of 'moving endpoint' time series models provide substantially improved tracking of the historical term structure and generally support the internal consistency of the ex ante long-run expectations of bond traders and survey respondents.     

分形粗糙面的电磁散射－扩展边界条件

用扩展边界条件方法对分形粗糙良导体面及介质面的电磁散射问题进行了分析。用推广的Floquet模式，在分界面处将场分量用Fourier级数展开，根据边界条件及扩展边界条件得到了水平极化和垂直极化散射场的幅度分量的表达式。用其它近似方法（Kirchhoff和Rayleigh方法）及能量守恒准则验证了此方法的有效性。     

河口水流、波浪、潮流、泥沙、河床变形二维数学模型

根据河口“波浪掀沙，潮流输沙”的泥沙运动机制，引入“波浪幅射应力”反应波浪对水体和泥沙的驱动力．考虑波浪对底部泥沙作用力、波浪对水流挟沙能力的影响及风场对水流和泥沙运动的影响．同时考虑泥沙粒径大小、水体含盐度、含沙量及水流紊动程度等因素对絮凝沉速的影响．用ＡＤＩ算法求解沿水深平均方程，破开算子法解悬移质不平衡输沙方程及河床变形方程，引入通度概念处理岸滩不规则边界，建立河口水流、波浪、潮流、泥沙、河床变形二维数学模型．通过实测资料及卫星摇感图像对所建数学模型进行检验，表明它可以较好地预测河口泥沙的运动     

三维有自由表面问题的数值模拟研究

本文采用求解三维弱可压流动模型及带浮力修正的Ｋ－ε两方程湍流模型的方法，用有限差分法数值求解，研究了有密度差的污染物在复杂流场中的对流扩散规律。文中给出一种简单而有效的处理自由面边界的方法，并详细地给出一个三维弱可压的流体动力学计算方法，数值计算表明本文的方法能较好地给出自由面的变化规律、流场的非定常过程及预测了污染物的对流扩散规律。     

用边界拟合坐标下的有限差分法评价城市的地下水资源

本文给出了边界拟合坐标系下的二维地下的二维地下水流的基本方程，并且用该坐标系下的有限差分法对江苏某市的承压水和潜水资源进行评价。预测了１９９１－２０００年的地下水流场，边界拟合坐标下的ＡＤＩ法的计算结果和实测水位比较一致，表明该方法在地下水资源评价中有实际应用价值，尤其在处理边界几何形状复杂的地下水流问题时更为有效。     

NUMERICAL MODEL FOR DYNAMIC SIMULATION OF TRAFFIC FLOW

ＮＵＭＥＲＩＣＡＬＭＯＤＥＬＦＯＲＤＹＮＡＭＩＣＳＩＭＵＬＡＴＩＯＮＯＦＴＲＡＦＦＩＣＦＬＯＷＷｕＺｈｅｎｇ；ＺｅｎｇＬｉ－ｎｏｎｇ（ＤｅｐａｒｔｍｅｎｔＡｐｐｌｉｅｄＭｅｃｈａｎｉｃｓ，ＦｕｄａｎＵｎｉｖｅｒｓｉｔｙ，Ｓｈａｇｈａｉ２００４３３，Ｐ...