KDR基因遗传变异对贝伐珠单抗一线治疗晚期非小细胞肺癌患者临床疗效的影响

目的: 本研究旨在探讨激酶插入区受体（KDR）基因遗传变异对贝伐珠单抗联合化疗治疗晚期非小细胞肺癌（NSCLC）患者疗效的影响。方法:本研究纳入135例一线接受贝伐珠单抗治疗的NSCLC患者,收集外周血及活检癌组织标本分别用来进行基因分型及表达测定。多态性位点的基因型和其他变量的相关性通过logistic回归模型进行分析。基因型和预后的单变量分析用Kaplan-Meier生存分析方法,并通过Cox风险比例模型对其他变量进行校正。结果:在KDR的标记多态性位点中,只发现了V297I位点的临床意义。V297I位点位于该基因的编码区,在研究人群的基因分布频率为：CC型99例（73.33%）,CT型33例（24.44%）,TT型3例（2.23%）,最小等位基因频率为0.14,三种基因型分布频率符合哈迪温伯格平衡（P=0.898）。后期比较将TT型和CT型患者合并,对不同基因型患者进行疗效分析发现：CT/TT基因型患者和野生型CC型患者的客观缓解率（ORR）分别为41.67%和47.47%（P=0.549）。CT/TT和CC基因型患者的中位无进展生存期（mPFS）分别为6.2和8.6个月,差异具有统计学意义（P=0.003）。在总生存期（OS）方面,两种基因型患者的中位总生存期（mOS）分别为18.9和21.5个月,差异具有统计学意义（P=0.017）。对无进展生存期（PFS）构建多变量的Cox模型校正之后发现CT/TT基因型对PFS的影响仍然具有统计学意义（OR=1.95,P=0.019）。另外,进一步在68例癌组织标本的表达分析中发现,CT/TT基因型患者相对于野生型的CC型患者,癌组织中KDR的表达明显较高,且差异具有统计学意义（P<0.01）。结论:在接受贝伐珠单抗治疗的非小细胞肺癌患者中,KDR基因V297I位点可能通过影响KDR基因的表达从而影响贝伐珠单抗一线治疗非小细胞肺癌患者的疗效。     

电源线滤波器对电子设备EMC影响分析

针对电子设备在电磁兼容(Electromagnetic Compatibility,EMC)测试中遇到的问题,从电源线滤波器内部电路入手,分析了电源线滤波器对电子设备EMC性能的影响。描述了如何根据电子设备内部电路、使用条件,尤其是输入端电路特性,对电源线滤波器的阻抗特性、插入损耗等参数进行正确选择。对于影响电子设备EMC性能的电源线滤波器的安装方法进行了分析、讨论,列举了2个实际测试例子,并对整改措施进行描述和分析。     

3dB带状线电桥的研究与设计

首先对90°电桥进行了分析。提出一种特殊结构的宽带3dB电桥的设计方案。该方案可使电桥方向性更好、制作工艺更加简便,其带宽可达到9～11GHz,可以承受较大的功率容量,体积小,新式结构使其实现了低插损、高方向性和宽频带,并且易生产、易调试。实测结果和仿真结果基本吻合,验证了研究结果的一致性。     

开关电源输入EMI滤波器设计与仿真

开关电源中常用EMI滤波器抑制共模干扰和差模干扰。三端电容器在抑制开关电源高频干扰方面有良好性能。文中在开关电源一般性能EMI滤波器电路结构基础上,给出了使用三端电容器抑制高频噪声的滤波器结构。并使用PSpice软件对插入损耗进行仿真,给出了仿真结果。     

Dynamic and kinetic modeling of isotopic transient responses for CO insertion on Rh and Mn–Rh catalysts

Isotopic transient tracer techniques have been employed to study heterogeneous hydroformylation on Rh/SiO₂ and Mn–Rh/SiO₂. Pulse injection of D₂ and allowed tracing of the deuterium and CO incorporation pathway into the aldehyde product. The d₁- and d₂-propionaldehyde responses showed a double-peak, or two-hump, response to the D₂ pulse, while showed a single-hump response to the pulse. Analysis of the product responses to the D₂ pulse in CO/H₂/C₂H₄ and CO/H₂/C₂H₄/C₂H₅CHO suggests that the first hump of the d₁- and d₂-propionaldehyde responses was due to rapid H/D exchange with adsorbed propionaldehyde via enol intermediates. The decay of the second hump was due to reaction of adsorbed acyl with spillover hydrogen/deuterium. The response was due to CO insertion followed by acyl hydrogenation. Compartment modeling of the product responses from the and D₂ pulse inputs allowed determination of residence times of adsorbed intermediates, surface coverages of adsorbed intermediates, and the elementary rate constants for acyl hydrogenation and CO insertion. Elementary rate constants for acyl hydrogenation determined from this study were consistent with the value calculated by transition state theory (TST). The addition of Mn promoter to Rh/SiO₂ increased coverages of , , and and shifted the rate-limiting step for propionaldehyde formation. Acyl hydrogenation is the rate-limiting step on Rh/SiO₂ while CO insertion and acyl hydrogenation are both kinetically significant on Mn–Rh/SiO₂.     

最晚截止期优先带宽转让算法

基于最早截止期优先调度的实时系统，针对有新任务插入(与/或)现行任务加速但系统带宽不足的问题，提出一种最晚截止期优先(LDF)算法，用于系统在运行时选择现行任务转让带宽。采用从最晚作业截止期任务开始判断的方法，经过尽可能少的比较次数，找到合适的受压任务，平滑地完成带宽转让。算法需要的最多比较次数为2n。仿真结果表明，该算法在大多情况下只需要比较1~2次即可完成压缩任务。     

A neural/fuzzy optimal process model for robotic part assembly

A process model for part assembly task, using robotic manipulators, is introduced. A neural network control strategy, based on measured force and moment data, for avoiding jamming during part insertion is presented. Fuzzy set theory, well-suited to the management of uncertainty, is introduced to address the uncertainty problem associated with the part insertion procedure. The degree of uncertainty associated with the part insertion is used as an optimality criterion for a specific task execution. The proposed technique is applicable to a wide range of robotic tasks including part mating with various shaped parts.     

Short communication: Recovery of viable Mycobacterium avium subspecies paratuberculosis from retail pasteurized whole milk in Brazil

Mycobacterium avium ssp. paratuberculosis (MAP) is the etiological agent of paratuberculosis, a chronic granulomatous enteritis that affects all ruminants worldwide. Some researchers have indicated a possible role of MAP in Crohn's disease. Despite extensive research and large and important advances in the past few decades, the etiology of Crohn's disease remains indefinite. The most probable transmission route of MAP from animals to humans is milk and dairy products. Mycobacterium avium ssp. paratuberculosis has already been detected in milk samples worldwide, and some studies have reported that MAP is resistant to pasteurization. In Brazil, MAP has been reported in raw milk samples; however, Brazilian retail pasteurized milk has not yet been tested for viable MAP. The aim of this study was to investigate MAP in pasteurized milk in the region of Viçosa (Minas Gerais, Brazil). Thirty-seven samples were collected and processed for culture of MAP. One colony similar to MAP was observed and confirmed by IS900-nested PCR and sequencing. Analysis revealed 97 to 99% identity with the MAP K-10 strain. This study is the first report of the presence of MAP in retail pasteurized whole milk in Brazil.     

发电机定子现场下线施工工艺

发电机定子现场下线工作量大，施工工艺复杂，对施工的环境条件要求很高。江垭水电站为地下式厂房，施工期间空气相对湿度大，施工场地小，施工相互干扰大。叙述了江垭水电站发电机定子现场下线的施工工艺，介绍了定子电气试验的结果，并对如何控制发电机电晕电压采取的施工措施提出了看法。     

一个2—3树的top—down式插入算法

本文给出一个新的2-3树插入算法ZZ.算法ZZ以top-down方式实现关键字的插入及所需的分裂.与算法Z相比,本算法的时间因子有所改进.然后,本文给出算法Z的两个反例,并对算法ZZ的正确性加以证明.