皮肤T细胞淋巴瘤局部用药和物理治疗的研究进展

皮肤T细胞淋巴瘤(cutaneous T cell lymphoma,CTCL)大多属于惰性淋巴瘤,病情进展缓慢,患者确诊时多处于疾病早期。局部用药和物理治疗在CTCL治疗中占重要地位,包括局部外用皮质类固醇激素、免疫抑制剂、维A酸,放疗及光疗等。近年来,有研究对CTCL传统局部用药和物理治疗方法的有效性和安全性进行了重新评估。同时,新型CTCL局部用药和物理治疗策略也不断涌现,如局部外用他扎罗汀、瑞喹莫特,紫外线A联合新型光敏剂的光化学疗法和光动力治疗等。本文对CTCL局部用药和物理治疗的研究进展作一综述。     

An experimental investigation of refrigerant mixture R32/R290 as drop-in replacement for HFC410A in household air conditioners

In the present paper, the refrigerant mixture R32/R290 (68%/32% by weight) is investigated as the drop-in replacement for R410A in household air conditioners. The GWP of it is only 22% of that of R410A. Theoretical and experimental investigations are conducted on the performance of the air conditioners working with both R32/R290 and R410A. Experimental results show that the refrigerant charge amount of R32/R290 is reduced by 30.0%–35.0%; the cooling and heating capacities are increased by 14.0%–23.7%. For further reducing charge amount and flammability, the micro-channel heat exchanger (condenser) is employed to replace the finned tube one. Compared with the R32/R290 system using finned tube heat exchanger, the R32/R290 charge amount and the power consumption are reduced by 34.1% and 0.4%, respectively; the cooling capacity and the COP are increased by 6.4% and 6.8%, respectively.     

Reducing the power consumption of household refrigerators through the integration of latent heat storage elements in wire-and-tube condensers

This study evaluates the influence of latent heat storage elements on the condenser temperature of a commercial household refrigerator. In order to determine the power consumption and the temperature distribution, a standard wire-and-tube condenser is equipped with different heat storage elements (containing water, paraffin or copolymer compound). The results indicate that particularly the application of phase change materials (PCM) lowers the condenser temperature, which leads to a significantly reduced power consumption.     

Effect of expander shape on cooling characteristics by using a model pulse tube refrigerator

Pulse tube refrigerators do not have moving parts in the cold section, and they have low vibration, high reliability, and long life. The expander in refrigerators typically has an inverted U or coaxial shape because this attains a wider absorber area, lower height, and compactness. However, the performance of a Stirling-type pulse tube refrigerator is inferior to that of a Stirling refrigerator. Cooling characteristics of the pulse tube refrigerator greatly depend on the shape of the expander. In this study, an inertance-type refrigerator, which uses ambient air for the working gas, was developed to examine the effect of expander shape. This refrigerator model with changeable expander operated with a Stirling cycle, and it was composed of a reciprocating compressor, after-cooler, regenerator, absorber, pulse tube, hot-end, and inertance tube with reservoir. The following expander shapes were tested: in-line, L shape, L-L shape, and coaxial shape. The effect of expander shape on cooling capacity was examined experimentally and numerically using the model pulse tube refrigerator. The results of experiments showed that the L shape expander had the highest performance and the coaxial expander had the lowest performance. In addition, the characteristics of the gas flow in each expander were confirmed by fluid dynamics analysis.     

Experimental investigation and analysis of composite silica-gel coated fin-tube heat exchangers

Desiccant coated heat exchanger provides a promising option for desiccant cooling system, since it can handle sensible load and latent load simultaneously within one component. It is fabricated by coating desiccant material on the surface of conventional fin-tube heat exchanger. In order to enhance the performance of conventional silica gel coated heat exchanger (SGCHE), a novel composite silica gel coated heat exchanger (CCHE) is proposed and fabricated. An experimental setup is built to test and compare the dynamic performance of SGCHE and CCHE. Influences of main operation parameters including water temperatures and inlet air conditions on system performance are analyzed in terms of average dehumidification capacity (D_avg) and thermal coefficient of performance (COP_th). Optimization of cycle switch modes is also discussed. Experimental results show that CCHE has better dehumidification performance compared with SGCHE. In addition, pre-cooling before dehumidification process is found to be advantageous to both D_avg and COP_th.     

New optimized model for water temperature calculation of river-water source heat pump and its application in simulation of energy consumption

The energy consumption calculation plays an important role in the analysis of project economic and social benefits. In order to calculate energy consumption accurately, this research presents a water temperature of condenser inlet calculation model of river-water source heat pump unit. The feasibility and calculation error of the model had been analyzed. Additionally, the new water temperature calculation model had been validated via an engineering case. The results showed that the hourly water temperature in 24 h could be replaced by daily average water temperature due to little change of the daily water temperature change. In this case, the calculation error could be less than 5%. It is found that despite water temperature has many influenced factors, there is a remarkable relationship between the daily average water temperature and daily average outdoor dry bulb temperature by data analysis (R² ≈ 0.9). The influence of river sampling location on water temperature calculation of condenser inlet could be ignored due to slight temperature changes (within 0.15 °C). The method proposed in this paper met the engineering accuracy and provided a very effective method for the engineering calculation of energy consumption of water chilling unit.     

冷冻与干燥能量循环利用技术的应用研究

在制冷工程中,制冷剂在冷凝过程中的热量往往被直接排放到周围环境而被浪费掉。从节能环保的角度出发,研究了有效提高压缩机排气温度以提升制冷剂所携带的热量品质,并通过换热回收将该部分热量用于干燥室烘干农产品的加工方法。此法既提高了系统整体性能系数,又节省了设备投资,对于伴随冷冻需求的农产品干燥加工有一定的指导意义。     

Experimental investigation of the effect of condenser subcooling in R134a and R1234yf air-conditioning systems with and without internal heat exchanger

This paper presents an experimental study about the effect of condenser subcooling on the performance of an air conditioning system operating with R134a and R1234yf, under the same operating conditions. For both refrigerants, it has been shown that the COP undergoes a maximum as a consequence of the trade-off between increasing refrigerating effect and increasing specific compression work. At a given operating condition, the system COP increased up to 18% for R1234yf and 9% for R134a. These results confirmed the trends obtained from a previous theoretical analysis, demonstrating that a system operating with R1234yf can benefit more from the condenser subcooling than that with R134a. The experimental results also showed that the presence of an internal heat exchanger significantly reduces the COP increase due to condenser subcooling, since both improvements compete towards reducing the throttling losses. Besides the interference between IHX and condenser subcooling, the use of both simultaneously still yields a more efficient air conditioning system, especially for R1234yf.     

Experimental and numerical study of the compact heat exchanger with different microchannel shapes

Experimental and numerical analysis of heat transfer and fluid flow in the compact heat exchanger has been done in this paper. In an open circuit wind tunnel, developed on purpose for this investigation, the measurement of working media temperatures and mass flow rates for heat exchanger with microchannel coil has been accomplished. In accordance with the heat exchangers used for experiments, numerical 3D simulation of adequate geometry shapes has been done. With utilization of air/water side numerical simulation, more detailed results have been achieved in relation to the simulation that assumes constant temperature or constant heat flux on the pipe wall. Good agreement between experimentally measured and numerically calculated results has been accomplished. The influence of different microchannel shapes on heat transfer effectiveness and pressure drop has been studied numerically. Comparison of results has been made accompanied by the discussion and final conclusions.