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991.
细胞间黏附分子1基因K469E多态性与冠状动脉粥样硬化性心脏病的关联研究 总被引:2,自引:0,他引:2
目的研究中国汉族人群中细胞间黏附分子1(intercellular adhesion moleculel,ICAM1)基因K469E多态性与冠状动脉粥样硬化性心脏病(简称冠心病)的关联。方法采用聚合酶链反应.限制性片段长度多态性方法检测了173例冠心病患者和141名对照的ICAM1基因K469E基因型和等位基因的分布。结果基因型频率符合Hardy-Weinberg平衡。冠心病组的KK基因型的频率显著高于对照组(64.2%比48.9%,P〈0.01),同样,冠心病组K等位基因的频率显著高于对照组(79.2%比69.9%,P〈0.01)。经Logistic回归分析排除年龄,性别,和冠心病其它危险因素的影响后,KK纯合子患冠心病的危险性是KE和EE基因型的2.35倍(95%CI:1.03-5.36,P〈0.05)。结论ICAM1基因K469E多态性与中国汉族人冠心病的危险性相关,其中K等位基因可能是冠心病的遗传危险因素。 相似文献
992.
Green EK Priestley MD Waters J Maliszewska C Latif F Maher ER 《Journal of medical genetics》2000,37(8):581-587
Distal deletion of chromosome 3p25-pter (3p− syndrome) produces a distinct clinical syndrome characterised by low birth weight, mental retardation, telecanthus, ptosis, and micrognathia. Congenital heart disease (CHD), typically atrioventricular septal defect (AVSD), occurs in about a third of patients. In total, approximately 25 cases of 3p− syndrome have been reported world wide. We previously analysed five cases and showed that (1) the 3p25-pter deletions were variable and (2) the presence of CHD correlated with the proximal extent of the deletion, mapping a CHD gene centromeric to D3S18. To define the molecular pathology of the 3p− syndrome further, we have now proceeded to analyse the deletion region in a total of 10 patients (five with CHD), using a combination of FISH analysis and polymorphic markers, for up to 21 loci from 3p25-p26. These additional investigations further supported the location of an AVSD locus within 3p25 and refined its localisation. Thus, the critical region was reduced to an interval between D3S1263 and D3S3594. Candidate 3p25 CHD genes, such as PMCA2 (ATP2B2), fibulin 2, TIMP4, and Sec13R, were shown to map outside the target interval. Additionally, the critical region for the phenotypic features of the 3p− phenotype was mapped to D3S1317 to D3S17 (19-21 cM). These findings will accelerate the identification of the 3p25 CHD susceptibility locus and facilitate investigations of the role of this locus in non-syndromic AVSDs, which are a common form of familial and isolated CHD.
Keywords: congenital heart disease; chromosome 3p25 相似文献
Keywords: congenital heart disease; chromosome 3p25 相似文献
993.
Markus M. Nthen Gisela Knpfle Hans-Jrg Fdisch Klaus Zerres 《American journal of medical genetics. Part A》1993,46(4):467-470
We report on a fetus with alobar holoprosencephaly, microphthalmia, midline cleft lip and palate, absent nose, dysplastic ears, radial defects, pentalogy of Fallot, unilateral renal aplasia, absent gallbladder, vertebral anomalies, and absence of ribs. The father had a cleft palate, bilateral colobomas of the iris and retina, a bifid uvula, vertebral anomalies, and unilateral congential hearing loss. His sister had a cleft lip. On the basis of this family and the family reported by Steinfeld [1982], this malformation syndrome can be defined as a rare autosomal dominant syndrome whose main component manifestations are holoprosencephaly, predominantly radial limb deficiency, heart defects, kidney malformations, absence of gallbladder, and vertebral anomalies. © 1993 Wiley-Liss, Inc. 相似文献
994.
A. I. KUZMIN V. M. POGORELOV D. V. ZARETSKY O. S. MEDVEDEV E. I. CHAZOV 《Acta physiologica (Oxford, England)》1995,155(2):147-155
Using microdialysis, extracellular 3,4-dihydroxyphenylalanine (DOPA), noradrenaline (NA) and adrenaline (AD) concentrations in the adrenal gland were monitored in conscious rats during and after 60 min of immobilization (IMM) as well as after injection of 500 mg kg-1 2-deoxyglucose (2-DG). IMM produced a rapid and transient increase in secretion of AD (20-fold), NA (13-fold) and DOPA (3.6-fold). This was accompanied by an increase in blood pressure (+ 18 mmHg) and heart rate (- 146 b. p.m.). Repeated exposure to IMM (daily 60 min, for 5 days) had no influence on either catecholamine secretion of haemodynamic profiles, indicating the lack of habituation to stressful conditions. Unlike IMM, the stress of 2-DG-induced centralneuroglucopenia stimulated the release of AD without affecting NA secretion. AD levels peaked (5.1-fold increase) 4&60 min after 2-DG injection and then slowly declined. 2-DG induced no changes in blood pressure but reduced the heart rate (-48 b. p.m.). In separate experiments, steady-state dialysate DOPA levels, reached during continuous infusion of decarboxylase inhibitor NSD 1015 into adrenal gland tissue through the dialysis probe, served as an index of adrenomedullary tyrosine hydroxylase (TH) activity. IMM evoked a marked increase in TH activity (DOPA formation increased 2.7-fold), which remained elevated 60 min after the cessation of stress when AD and NA secretion had already fallen to baseline. After 2-DG, despite significant hormonal response, adrenal TH activity was unchanged. These results give clear evidence that IMM and 2-DG-induced neuroglucopenia may be considered as two different types of stressful stimuli. 相似文献
995.
D. J. PATERSON 《Acta physiologica (Oxford, England)》1996,156(3):287-294
In exercise, potassium (K+) is released from contracting muscle predominately through K+ channels associated with the repolarization phase of the action potential. Increases in extracellular K+ are directly related to increases in metabolic rate and may reach concentrations as high as 8–9 mm in the arterial blood during exhaustive work. Exercise-induced hyperkalaemia has been implicated in several physiological processes, in particular skeletal muscle fatigue, hyperaemia, pressor reflex, arterial chemosensitivity and myocardial stability. There is no direct evidence to show that hyperkalaemia causes muscle fatigue, although raised extracellular [K+] may contribute to fatigue during prolonged tetani by depressing the propagation of the action potential down the t-tubule system, thus impairing the release of Ca2+ from the sarcoplasmic reticulum. The vasodilating properties of K+ may transiently contribute to the early phase of exercise hyperaemia and interact synergistically with other vasoactive substances to cause relaxation by hyperpolarizing K+ channels in vascular smooth muscle. Hyperkalaemia has been implicated in the regulation of arterial blood pressure through activation of the muscle afferent reflex where potassium-depolarized C fibres may contribute to a reflex increase in arterial blood pressure. K+ can also increase ventilation and the sensitivity of the ventilatory response to hypoxia through direct excitation of the arterial chemoreceptors. Finally, to maintain myocardial electrical stability in exercise, there is a beneficial interaction between raised K+ and catecholamines on the heart, so that when they combine, each offsets the other's deleterious effects. 相似文献
996.
Atrial automaticity and atrioventricular conduction in athletes: contribution of autonomic regulation 总被引:2,自引:0,他引:2
Stein R Moraes RS Cavalcanti AV Ferlin EL Zimerman LI Ribeiro JP 《European journal of applied physiology》2000,82(1-2):155-157
Little is known about the sinoatrial automatism and atrioventricular conduction of trained individuals who present a normal
resting electrocardiogram. We used transesophageal atrial stimulation, a minimally invasive technique, to evaluate aerobically
trained athletes (n=10) and sedentary individuals (n=10) with normal resting electrocardiograms, to test the hypothesis that parasympathetic tone, as detected by heart rate variability,
could be associated with changes in sinoatrial automatism and atrioventricular conduction. Corrected sinus node recovery time
tended to be longer in athletes than in sedentary individuals, but this difference did not reach statistical significance.
The Wenckebach point occurred at a lower rate in athletes than in the controls. Over a 24-h period of measurement, the mean
RR interval was longer in the athletes than in the sedentary individuals. The mean square root of successive differences (rMSSD)
tended to be higher in athletes than in controls, but this difference did not reach statistical significance. There was a
moderate correlation (r=0.48, P < 0.05) between the index of atrioventricular conduction, the rate at the Wenckebach point, and the logarithmically transformed
rMSSD. Thus, as a corollary to its effects on the sinus node, where increased parasympathetic tone, decreased sympathetic
tone, and non-autonomic components may contribute to sinus bradycardia, it is possible that athletic training may also induce
intrinsic adaptations in the conduction system, which could contribute to the higher prevalence of atrioventricular conduction
abnormalities observed in athletes.
Accepted: 2 January 2000 相似文献
997.
Haemodynamic Adjustments to Mental Stress in Normotensives and Subjects with Mildly Elevated Blood Pressure 总被引:1,自引:0,他引:1
Cardiac output, heart rate, stroke volume, pre-ejection period, total peripheral resistance, systolic and diastolic blood pressure, and oxygen consumption were monitored or derived in young men with mildly elevated casual blood pressures and unambiguously normotensive control subjects before, during, and after exposure to a mental arithmetic stress. Measurements were also taken while subjects underwent graded dynamic exercise. This permitted cardiac output-oxygen consumption regression equations to be calculated and, as a consequence, cardiac output during mental stress to be represented as additional cardiac output. Systolic and diastolic blood pressure were higher during all phases of the study in the mildly elevated blood pressure group. An overall groups effect during the mental stress phase of the experiment was observed for cardiac output and pre-ejection period, and the effect for stroke volume was close to significance. Significant Groups X Periods interactions were found for cardiac output and additional cardiac output, and the heart rate effect was nearly significant. Post-hoc comparisons here indicated that, in the main, group differences in these cardiac variables were more evident during the mental arithmetic stress than during the pre- and post-task baseline periods. Total peripheral resistance did not differ reliably between groups and the cardiac effects were specific to the mental stress phase of the study. 相似文献
998.
目的 观察压力负荷性左室肥厚大鼠心功能异常及心肌钠钙交换体(NCX)和肌浆网钙泵(SERCA2a)的表达变化.方法 缩窄大鼠腹主动脉制备压力负荷性心肌肥厚模型,测定在体血流动力学及左室重量指数(LVWI),用RT-PCR和Western blot法检测左室组织NCX及SERCA2a的表达.结果 与假手术组相比,模型大鼠左室收缩压(LVSP)及左室舒张末压(LVEDP)均显著升高(P<0.01,P<0.001);左室重量指数显著增加(P<0.001)及左室NCX mRNA表达上调(P相似文献
999.
David J McCulley Ji-One Kang James F Martin Brian L Black 《Developmental dynamics》2008,237(11):3200-3209
The endocardial cushions play a critical role in septation of the four-chambered mammalian heart and in the formation of the valve leaflets that control blood flow through the heart. Within the outflow tract (OFT), both cardiac neural crest and endocardial-derived mesenchymal cells contribute to the endocardial cushions. Bone morphogenetic protein 4 (BMP4) is required for endocardial cushion development and for normal septation of the OFT. In the present study, we show that anterior heart field (AHF)-derived myocardium is an essential source of BMP4 required for normal endocardial cushion expansion and remodeling. Loss of BMP4 from the AHF in mice results in an insufficient number of cells in the developing OFT endocardial cushions, defective cushion remodeling, ventricular septal defects, persistent truncus arteriosus, and abnormal semilunar valve formation. 相似文献
1000.
A two-component event-related brain potential consisting of an error-related negativity (ERN/Ne) and positivity (Pe) has been associated with response monitoring and error detection. Both the ERN and Pe have been source-localized to the anterior cingulate cortex (ACC)--a frontal structure implicated in both cognitive and affective processing, as well as autonomic nervous system (ANS) modulation. The current study sought to examine the relationships among the ERN, the Pe, two autonomic measures, and behavior. Electroencephalogram (EEG), heart rate (HR), and skin conductance (SC) were recorded while subjects performed a two-choice reaction-time task. In addition to the characteristic ERN-Pe complex, errors were associated with larger SCRs and greater HR deceleration. The ERN correlated with the number of errors, but was unrelated to ANS activity and compensatory behavior. Pe, on the other hand, was correlated significantly with SCR, and both SCR and Pe were significantly correlated with post-error slowing. 相似文献