Hyaluronan and the Fascial Frontier

The buzz about hyaluronan (HA) is real. Whether found in face cream to increase water volume loss and viscoelasticity or injected into the knee to restore the properties of synovial fluid, the impact of HA can be recognized in many disciplines from dermatology to orthopedics. HA is the most abundant polysaccharide of the extracellular matrix of connective tissues. HA can impact cell behavior in specific ways by binding cellular HA receptors, which can influence signals that facilitate cell survival, proliferation, adhesion, as well as migration. Characteristics of HA, such as its abundance in a variety of tissues and its responsiveness to chemical, mechanical and hormonal modifications, has made HA an attractive molecule for a wide range of applications. Despite being discovered over 80 years ago, its properties within the world of fascia have only recently received attention. Our fascial system penetrates and envelopes all organs, muscles, bones and nerve fibers, providing the body with a functional structure and an environment that enables all bodily systems to operate in an integrated manner. Recognized interactions between cells and their HA-rich extracellular microenvironment support the importance of studying the relationship between HA and the body’s fascial system. From fasciacytes to chronic pain, this review aims to highlight the connections between HA and fascial health.     

基于移动IPv6的平滑切换算法研究

切换时延和数据包丢失一直是制约移动IPv6发展的关键因素.文章针对现有切换算法及存在的问题进行了分析,然后在现有算法的基础上提出了一种改进算法.仿真实验结果表明,该算法能有效地抑制因移动节点的网络切换而导致的通信节点拥塞控制机制的启动,提高了移动网络数据流的正确率和吞吐量,进而提高了移动网络的通信质量.     

玻璃质酸钠润肤霜的处方设计探讨

透明质酸（Hyaluronic Acid,简称HA）的独特分子结构和理化性质使其具有特殊的保湿作用。通过采用不同乳化剂、选取不同配比以及不同的乳化方法配制玻璃质酸钠高级润肤霜,并根据处方稳定性试验研究生产工艺,润肤霜处方工艺能应用于工业化生产。     

生物医用纳米羟基磷灰石(HA)的制备及性能测试

HA是一种活性陶瓷材料,由于其成份接近生物机体骨骼的无机成份、能诱发新骨生长、具有良好的生物相容性和生物活性等特点,作为替代材料已广泛应用于人体硬组织的修复。本文主要研究HA的制备方法及其性能。     

超临界CO2中制备聚乳酸/羟基磷灰石复合支架材料

利用盐析/超临界CO2复合方法制备了一系列的PDLLA/HA三维多孔支架材料.利用这种方法可以避免使用有机溶剂、较高温度和降低常规气体发泡法所需的较长时间.制备的三维多孔支架的孔隙率最高达91%,孔与孔之间相互连通,孔分布均匀,孔径大小为100～300μm,抗压强度明显增加.详细研究了CO2压力、温度、浸润时间以及致孔剂含量等条件的变化对复合材料形貌和孔隙率的影响.     

Ultrasonication‐Induced Modification of Hydroxyapatite Nanoparticles onto a 3D Porous Poly(lactic acid) Scaffold with Improved Mechanical Properties and Biocompatibility

A 3D porous poly(lactic acid) (PLA) scaffold with high porosity and well‐connected pores is fabricated using a vacuum‐assisted solvent casting technique. Its surface is modified with hydroxyapatite (HA) nanoparticles using ultrasonication to prepare an HA‐modified PLA/HA scaffold. For reference, an HA‐blended (b‐PLA‐HA) scaffold is fabricated via the solution blending method. The morphology, porosity, hydrophilicity, swelling ratio, mechanical properties, and cell viability of the PLA, b‐PLA‐HA, and PLA/HA scaffolds are systematically studied. The results show that HA nanoparticles are successfully introduced onto the surface of the PLA/HA scaffold, and strong interactions occur between the HA nanoparticles and the PLA matrix. The PLA/HA scaffold still has a high porosity of more than 85% after ultrasonication. The hydrophilicity and mechanical properties of the PLA/HA scaffold are significantly higher than those of the PLA and b‐PLA‐HA scaffolds. Compared with the PLA and b‐PLA‐HA scaffolds, the attachment and growth of mouse embryonic osteoblasts cells (MC3T3‐E1) cultured on the PLA/HA scaffold significantly improve, due to most HA nanoparticles on the surface, resulting in a good and direct interaction between the cells and the scaffold. Therefore, the PLA/HA scaffold possesses great potential to be used as a tissue engineering scaffold.     

腐殖酸表面接枝对丙烯酸类超强吸水树脂的改性研究

采用腐殖酸（HA）溶液处理丙烯酸类超强吸水树脂颗粒，对丙烯酸类超强吸水树脂颗粒进行表面接枝改性，研究了HA表面改性对丙烯酸类超强吸水树脂颗粒吸水性能、吸水速度以及表面结构的影响。结果表明，HA改性后的吸水树脂颗粒其吸收蒸馏水的能力提高30％，吸收生理盐水的能力可以提高1．1倍，达到饱和溶胀所需要的时间降低，防潮性能大大提高，电镜照片显示吸水树脂颗粒表面形成明显的层状膜。     

“一步法”制备纳米相丝素蛋白/羟基磷灰石生物复合材料

系统分析了羟基磷灰石（HA）的制备方法和丝素蛋白纤维（SF）的溶解方法,提出一种制备纳米丝素蛋白/羟基磷灰石生物复合材料（SF/HA）的新型反应复合方法——“一步法”。并对由“一步法”制得的SF/HA分别进行了钙磷比测定、红外光谱测试、透射电镜观察和X射线衍射测试。结果表明：SF/HA中的钙磷比是1.6692,与标准HA中的钙磷比1.67一致;SF/HA中同时含有SF和HA中各自的官能团;SF/HA的晶粒横向尺度小于100 nm,SF/HA呈针状或柱状晶粒, SF和HA能够形成复合; SF/HA的晶型属于六方晶系, 当SF在SF/HA中所占质量分数为10%时,晶胞参数a=b=9.0319 A,c=7.0148 A,沿c轴方向平均晶粒尺寸是230.7645 A。“一步法”制备SF/HA具有合理性和可行性。     

羟基磷灰石生物复合材料的应用进展

综述了羟基磷灰石(HA)与无机、有机及金属材料的三种复合材料的研究应用与进展;分析了目前各种复合材料存在的主要问题;讨论了羟基磷灰石复合材料的发展方向。     

激光熔覆SiO2/La2O3梯度生物陶瓷涂层生物活性研究

目的研究SiO_2含量对钛合金表面激光熔覆梯度生物陶瓷涂层生物活性的影响。方法利用激光熔覆技术,采用梯度成分设计思想,固定涂层中稀土氧化物La_2O_3的添加量,在钛合金TC4表面制备了掺杂不同含量SiO_2的梯度生物陶瓷涂层。采用金相显微镜(OM)、X射线衍射仪(XRD)、扫描电子显微镜(SEM)、噻唑蓝(MTT)及荧光素双醋酸酯(FDA)染色等测试手段,研究了SiO_2含量对激光熔覆制备梯度涂层的组织结构和生物活性的影响。结果 SiO_2在激光熔覆过程中可以降低梯度生物陶瓷涂层的开裂敏感性,并起到细化晶粒的作用。当SiO_2掺杂量为2.5%时,激光熔覆过程中诱导合成的HA+CaTiO_3数量最大;当SiO_2掺杂量为7.5%时,模拟体液(SBF)实验表明,涂层的矿化沉积能力最强。MTT测试表明,SiO_2掺杂量为7.5%的涂层细胞增殖数量的OD值最大,细胞能够紧贴涂层表面生长。FDA染色分析表明,SiO_2掺杂量为7.5%的涂层上细胞数量最多,且分布均匀。结论 SiO_2掺杂量深刻影响着生物活性陶瓷相HA和Ca_2SiO_4数量,进而影响生物陶瓷涂层的生物活性。SiO_2掺杂量为7.5%的涂层具有最佳的生物相容性及生物活性。