VMI模式下的供应商评价在汽车制造业的应用研究

自2008年蔓延开来的全球性经济危机给汽车制造业带来了沉重的打击,在经济全球化的背景下,雷曼兄弟的倒闭,美国通用、福特、克莱斯勒三大汽车制造商的重组,都对我国汽车制造业带来了严重的冲击。从我国汽车制造业采用的VMI模式进行供应商管理出发,探讨VMI模式下汽车整车制造商对战略供应商的绩效评价体系的有效模式,可以帮助我国汽车制造企业在这个重要的时期提升自身实力,提高供应链运营效率。     

精细化管理在油气输送钢管制造企业中的构建与实施

论述了以＂五精四细＂为模式的精细化管理在渤海石油装备华油钢管公司内的构建和实施。详细阐述了＂五精四细＂的基本内涵,即五精之精化、五精之精髓、五精之精品、五精之精通、五精之精密、四细之细分、四细之细密、四细之细化、四细之细则。通过实施精细化管理,企业管理水平得到全方位提升     

Cost-minimisation analysis of erlotinib in the second-line treatment of non-small-cell lung cancer: a Brazilian perspective

Abstract

Objective: A cost-minimisation and budget impact analysis of erlotinib versus docetaxel or pemetrexed as second-line treatment for advanced non-small-cell lung cancer (NSCLC).

Methods: Costs and budgetary impacts were estimated from the perspective of a Brazilian private healthcare payer, based on results of the BR.21 study of erlotinib and pivotal trials of docetaxel and pemetrexed. A 126-day timeframe was evaluated, based on the progression-free survival determined for erlotinib in BR.21. A Delphi panel identified local practices and associated costs in Brazil. Other costs accounted for included medical payments, pre- and post-chemotherapy medication and drug administration costs. Multivariate sensitivity analyses were performed, but given the short time frame used, discounting was not applied.

Results: Total costs were R$26,825 for erlotinib, R$42,284 for docetaxel and R$79,841 for pemetrexed. Cost savings with erlotinib were attributable to lower acquisition costs (R$26,795 vs. R$40,217 for docetaxel and R$78,911 for pemetrexed) and lower costs for the management of side effects. Sensitivity analyses confirmed the robustness of the results. The budget impact analysis showed savings with erlotinib in the first year, ranging from R$3 million to R$28 million.

Conclusion: Erlotinib is cost-saving over established chemotherapy in the second-line treatment of advanced NSCLC under the Brazilian private healthcare system.     

应用型人才培养的高等数学教学改革

要培养应用型的人才,高等数学的教学应该改变教学理念,改革教学内容、教学方法和考核方式,培养学生运用数学知识解决实际问题的意识和能力。     

管棚法超前支护技术在破碎围岩隧洞开挖中的应用

本文介绍联补水电站导流洞开挖过程中,采取地质大管棚施工工艺进行隧洞超前支护的施工方法,成功进行平洞松软岩层开挖的施工经验。     

基于柔性生产型企业原料仓库内布局规划改造研究

基于柔性生产企业库内运作管理现状,分析库内存在的不合理因素并进行合理优化,提出相应整改方案和实施效果分析。     

Cost-effectiveness implications of increased survival with anastrozole in the treatment of advanced breast cancer

Summary

Anastrozole (Arimidex*) has a survival benefit compared with megestrol acetate in postmenopausal women with advanced breast cancer who have failed on tamoxifen. It was felt appropriate that such a clinical finding should be subjected to economic evaluation.

A cost-effectiveness analysis was undertaken from the viewpoint of a third-party payer, of the data from a combined analysis of two clinical studies. The outcome measures were duration of drug treatment and life years gained. The incremental cost effectiveness ratio (ICER) of anastrozole was £1,608 per life year gained based on UK NHS drug prices in April 1998. Sensitivity analysis showed that the ICER could vary between £5 and £1,643, depending on relative drug costs in a number of countries, between £1,056 and £1,761, depending on the method used to calculate duration of treatment and survival, and could increase to £3,730, based on treatment provided during the extra period of survival.

Anastrozole is a highly cost-effective alternative to megestrol acetate for postmenopausal women with advanced breast cancer.     

以农业技术进步为主线的农业科技园区的制度创新

我国要实现加快农业结构调整、提高农业整体效益、增加农民收入、改善生态环境、加速农业产业化进程目标就必须依靠推进农业技术进步和加强科技引导与示范。农业科技园区的生命力就在于对农业技术进步的巨大促进作用,即以农业技术进步为主线的农业科技园区的制度创新的带动作用:①农业科技体制创新;②农业生产经营制度的创新即农业产业化。     

代表先进文化必须做到“八结合”——学习江泽民“七一”讲话中关于先进文化的论述

中国共产党要始终代表中国先进文化的前进方向,就必须做到以下八方面的结合：物质文明建设和精神文明建设相结合、唱响主旋律和提倡多样化相结合、文化继承与文化创新相结合、依法治国与以德治国相结合、“一手抓繁荣”与“一手抓管理”相结合、实施精品战略与搞好文化普及相结合、强化科学意识与加强化大众意识相结合、加强文化建设与加强作风建设相结合。     

借鉴国际经验加快中国个人信用制度建设

从经济学理论看,个人信用制度的建设对一国经济的健康发展至关重要.应借鉴国外个人信用制度建设的成功经验,并结合中国具体国情,加快中国个人信用制度建设.