基于RL&SM通用夹具系统的主动寻位技术及其实现方法

介绍了RL&SM通用夹具的寻位系统 ,描述了主动寻位与制造信息转换问题 ,提出和实现了相应的控制方法及其系统实现中的关键技术。理论分析与实验结果表明 ,提出的解决方法和技术是可行的 ,为RL&SM通用夹具系统的实际应用奠定了理论基础和技术支持     

用增量有限元法计算金属流动

利用增量有限元理论 ,对金属材料的变形过程进行模拟。为了模拟工程中塑性变形较大的构件的变形规律 ,在每个加载步迭代完成后自动实现坐标更新。     

LehmerDH数在模p剩余系的分布

设 p≥ 3为素数 ,集合A ={a|1≤a 相似文献   

波纹纤维混凝土的动力耗散研究

根据曲线纤维的几何特点和受力性能 ,推导了波纹纤维混凝土的本构关系 ,在本构理论的基础上进行动力耗散研究     

入世对我国环保产业的影响及对策

通过对我国环保产业的市场绩效、整体实力及立法现状进行分析，并针对入世对我国环保产业在机遇与挑战两方面的影响进行深入探讨，提出了完善市场竞争体制以提高市场绩效、调整环保产业结构以增强整体实力、建构环保产业法律体系以维护市场运行等相应的对策。     

变频调速装置在离心机拖动系统上的应用

对离心机拖动系统进行变频改造 ,既节约大量电能和设备维修费用 ,提高安全生产可靠性 ,又能提高生产自动化水平     

轴对称辐射传递逆问题的三种求解算法比较

针对轴对称光学薄火焰,用图像探测器和滤色片获得火焰的单色辐射图像,根据火焰的单色辐射强度,分别采用最小二乘法、正则化方法和线性规划法对辐射传递逆问题进行了求解.对一个轴对称乙烯扩散火焰进行实验检测,通过对三种求解方法的结果比较,表明对辐射强度较高的火焰中部和上部区域,三种方法均可获得较好的重建结果;而对于辐射强度较低的火焰下部区域,由于线性规划法同时具有光滑性和约束性的优点,可以获得较好重建结果,它对求解轴对称辐射传递逆问题是一种比较理想的算法.     

廊坊市“文化信息资源共享工程”建设分析与研究

在介绍廊坊市“文化信息资源共享工程”建设现状基础上,阐述了资源共享的意义,分析了资源共享存在的问题,研究了相应的解决方法。     

The Shwachman-Bodian-Diamond syndrome protein mediates translational activation of ribosomes in yeast

The autosomal recessive disorder Shwachman-Diamond syndrome, characterized by bone marrow failure and leukemia predisposition, is caused by deficiency of the highly conserved Shwachman-Bodian-Diamond syndrome (SBDS) protein. Here, we identify the function of the yeast SBDS ortholog Sdo1, showing that it is critical for the release and recycling of the nucleolar shuttling factor Tif6 from pre-60S ribosomes, a key step in 60S maturation and translational activation of ribosomes. Using genome-wide synthetic genetic array mapping, we identified multiple TIF6 gain-of-function alleles that suppressed the pre-60S nuclear export defects and cytoplasmic mislocalization of Tif6 observed in sdo1Delta cells. Sdo1 appears to function within a pathway containing elongation factor-like 1, and together they control translational activation of ribosomes. Thus, our data link defective late 60S ribosomal subunit maturation to an inherited bone marrow failure syndrome associated with leukemia predisposition.     

Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL

Resequencing genes provides the opportunity to assess the full spectrum of variants that influence complex traits. Here we report the first application of resequencing to a large population (n = 3,551) to examine the role of the adipokine ANGPTL4 in lipid metabolism. Nonsynonymous variants in ANGPTL4 were more prevalent in individuals with triglyceride levels in the lowest quartile than in individuals with levels in the highest quartile (P = 0.016). One variant (E40K), present in approximately 3% of European Americans, was associated with significantly lower plasma levels of triglyceride and higher levels of high-density lipoprotein cholesterol in European Americans from the Atherosclerosis Risk in Communities Study and in Danes from the Copenhagen City Heart Study. The ratio of nonsynonymous to synonymous variants was higher in European Americans than in African Americans (4:1 versus 1.3:1), suggesting population-specific relaxation of purifying selection. Thus, resequencing of ANGPTL4 in a multiethnic population allowed analysis of the phenotypic effects of both rare and common variants while taking advantage of genetic variation arising from ethnic differences in population history.