可溶性细胞间黏附分子-1在急性肝内胆汁淤积兔模型中的表达

目的探讨可溶性细胞间黏附分子(sICAM-1)在急性肝内胆汁淤积兔模型中的表达及其意义。方法39只健康的新生大耳白兔随机分成4组:3个实验组(n=9)和1个空白对照组(n=12)。每个实验组分别为3个时间点处理组(24、48、72 h)。实验组采用1次灌服α-荼异硫氰酸盐(ANIT)200 mg/kg方法造成急性肝内胆汁淤积。按时分批取标本,检测其血清和胆汁中sICAM-1水平。结果实验组血清、胆汁中sICAM-1各时间点水平明显高于正常对照组(P均<0.05),其中48 h>72 h>24 h。结论sICAM-1在胆汁淤积中表达升高,与肝脏损伤程度和病程相关。     

冬凌草单药及与化疗合用治疗食管癌205例

目的:观察冬凌草单药及与化疗合用治疗食管癌的临床疗效.方法:448例患者,均经病理细胞学和X线检查确诊为食管癌.其中早期癌76例,均采用冬凌草单药治疗.晚期癌372例,167例采用冬凌草单药治疗,205例采用冬凌草与化疗合用.结果:用冬凌草单药治疗早期食管癌患者3,5,10,13 a的生存率明显高于未治疗组(98.68% vs 51.52%,84.02% vs 28.62%,63.49% vs 11.45%,50.13% vs 8.59%;P<0.001).对于晚期食管癌,冬凌草联合化疗应用,其总有效率明显高于以PYM(BLM)为基础的单一化疗(66.82% vs 42.85%,P<0.01).冬凌草与化疗合用组与单一化疗对照组相比副作用基本相同,无明显差异(P>0.05).结论:对于早期食管癌患者,冬凌草能控制疾病发展延长生存时间;对于晚期食管癌患者,冬凌草能增强化疗的作用.     

踝关节骨折腓骨钢板的后方固定

目的：探讨踝关节骨折中腓骨钢板固定的位置。方法：2001年1月～2003年1月共手术治疗踝关节骨折患者75例，仅对其中随访资料完整的48例患者进行分析。随访10～24个月，平均15个月。采用Baird和Jackson的踝关节评分系统评定踝关节术后疗效。结果：所有的患者均取得了良好的骨折愈合。术后疗效为优24例，良17例，可5例，差2例。优良率为85、4％。结论：腓骨钢板的后方放置可以减少缝合时的张力，钢板有更好的软组织覆盖，钢板无须过多塑形，固定比较牢固。     

环氧丙烷对实验动物肝脏的影响

用环氧丙烷对大鼠进行实验性肝中毒研究的结果表明:一定剂量的环氧丙烷可引起大鼠血清GPT、GOT活性升高;病理形态学检查肝组织呈炎症反应。     

乳腺良恶性病变的磁共振T2*W首过灌注成像与血管生成相关性研究

Objective： To study the diagnostic value of T2^＊-weighted first-pass perfusion imaging in breast tumors. Methods： We analyzed the magnetic resonance imaging （MRI） information along with the pathological and immunohistochemistry results. Magnetic resonance imaging was performed in 28 patients with breast tumor. The time to signal intensity curves were generated according to the T2^＊-weighted first-pass perfusion imaging. The curve＇s maximal signal intensity drop rate and maximal signal intensity decrease time were analyzed and compared with the pathological diagnoses after surgery. Results： Malignant breast lesions showed higher maximal signal intensity drop rate （44.69% ± 17.07 vs. 17.22% ±7.49, P 〈 0.001） than benign lesions, but there was no significant difference of maximal signal decrease time between those two lesions （23.94 s ± 4.92 vs. 20.02 s ± 6.83, P 〉 0.05）. Conclusion： The T2^＊-weighted first-pass perfusion imaging has enough sensitivity and specificity in breast tumor diagnosis.     

CT导向下~(125)I粒子植入治疗复发性盆腔恶性肿瘤

目的探讨CT导向下125I粒子植入治疗复发性盆腔恶性肿瘤的疗效。方法18例复发性盆腔恶性肿瘤患者采用CT导向下125I放射性粒子植入。粒子植入之前采用TPS模拟布源或遵循Halarism的125I经验公式:mCi=Da×5,Da为靶组织长、宽、高的平均值(L W H)/3,单位为cm,求出术中所需125I粒子的总活度及算出治疗粒子的数量。在螺旋CT导向下将125I放射性粒子植入盆腔肿瘤内。结果全组18例22个病灶治疗后2个月后采用PET-CT评价,完全缓解(CR)6例,部分缓解(PR)8例,稳定(NC)3例,进展(PD)1例。18例随访7~16个月,全部存活,近期平均生存期9.5个月。结论125I放射性粒子植入是治疗复发性盆腔恶性肿瘤的一种有效的方法。     

白术、枳实、玫瑰花挥发油-β-环糊精包合物的制备工艺研究

目的确定白术、枳实、玫瑰花挥发油-β-环糊精包合物的最佳包合工艺。方法采用正交试验法,对挥发油与β-环糊精的包合进行3因素3水平考察。结果挥发油与β-CD投料比为1:9,β-CD与加水量的比为9:100倍,包合时间为4h,包合率为85.3%。结论用此法得到的挥发油-β-环糊精包合物的包合率较高,包合物性质稳定,而且包合操作简单。     

中西医结合治疗类风湿性关节炎的临床研究

目的：观察滋肾通痹颗粒联合小剂量西药“采氟米特”治疗类风湿性关节炎患者临床疗效及免疫学指标的变化。方法：应用中药补肾滋阴类药物生地，女贞子、杜仲、鸡血藤等，联合西药“来氟米特”提高免疫功能，应用中药藤类药物宣痹通络。活血舒筋治疗“顽痹”。中西药结合治疗类风湿性关节炎（RA）患者共70例。治疗前后进行总疗效、主要症状、体征及实验室指标对比观察。结果：70例中临床治愈率24．3％；有效率25．7％；总有效率为94．3％。关节疼痛、肿胀。功能障碍指数、晨僵时间、双手握力和15米步行速度等观察指标治疗后明显优于治疗前（P〈0．01）。结论：中西医结合治疗RA能明显提高机体免疫能力。抗过敏、改善临床症状及实验室指标。中西医结合治疗RA能取长补短，增强疗效，减少副作用，减轻患者经济负担。可使RA患者长期维持治疗。     

Feasibility of treating hyperfibrinogenemia with intermittently administered batroxobin in patients with ischemic stroke/transient ischemic attack for secondary prevention.

This study evaluated the safety and efficacy of batroxobin in treating hyperfibrinogenemia for secondary stroke prevention. Patients with ischemic stroke or transient ischemic attack (TIA) were measured for plasma fibrinogen levels. Selected participants had concomitant hyperfibrinogenemia (plasma fibrinogen > or = 3.0 g/l). Patients enrolled between 1 July 2003 and 31 December 2004 were treated with batroxobin; patients enrolled between 1 January 2002 and 30 June 2003 were treated without batroxobin. Batroxobin was administered intermittently via intravenous injection at 3-monthly intervals. Patients in both groups were followed for 1 year. Any cerebrovascular events and suspected adverse events were recorded. In total, 112 ischemic stroke/TIA patients with concomitant hyperfibrinogenemia were enrolled, 52 being treated with batroxobin and 60 without batroxobin. Six patients (11.5%) with batroxobin and 16 patients (26.7%) without batroxobin had recurrent cerebral ischemic events during follow-up. Stroke/TIA recurrence in patients without batroxobin was higher than that in patients with batroxobin (P < 0.05). Two patients with batroxobin and two patients without batroxobin developed hemorrhagic stroke during follow-up. There were five deaths (9.6%) in the batroxobin group, and seven deaths (11.7%) in the nonbatroxobin group during follow-up (P > 0.05). Intermittent intravenous injection of batroxobin can efficiently reduce the risk for stroke/TIA recurrence in patients with concomitant hyperfibrinogenemia.     

两种隐匿阴茎大鼠模型的建立及比较

目的:建立稳定的大鼠隐匿阴茎模型,为探索阴茎包埋对海绵体结构和功能的影响提供实验动物模型。方法:90只2周龄雄性SD大鼠随机均分为A、B、C3组,A组采用阴茎根部内荷包缝合法,B组采用包皮折叠缝合法包埋阴茎,C组为假手术组。在180d内观察两种方法的包埋效果。结果:A组术后4只死于急性尿潴留,5只因尿道口周围软组织感染、皮肤破溃导致包埋失败,3只因包埋过松阴茎伸出;B组术后1只死于麻醉,2只死于急性尿潴留;因阴茎发育和勃起,A组有7只、B组有10只阴茎伸出;C组1只死于麻醉。A组和B组中其余大鼠均有较好的包埋效果,A组包埋成功率为36.7%,B组为56.7%,而且可以在实验中任何时候解除包埋。结论:包皮折叠缝合法和阴茎根部内荷包缝合法均能建立稳定的、且与人类隐匿阴茎自然病程较为一致的2周龄大鼠隐匿阴茎动物模型。