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71.
Pillai SK Abdel-Mohsen M Guatelli J Skasko M Monto A Fujimoto K Yukl S Greene WC Kovari H Rauch A Fellay J Battegay M Hirschel B Witteck A Bernasconi E Ledergerber B Günthard HF Wong JK;Swiss HIV Cohort Study 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(8):3035-3040
72.
Lee SY Miyai K Han HS Hwang DY Seong MK Chung H Jung BH Devaraj B McGuire KL Carethers JM 《Digestive diseases and sciences》2012,57(1):72-78
Background and Objectives
Colorectal tumors are often observed with tumor infiltrating lymphocytes, presumably as a host-immune response, and patterns may segregate by types of genomic instability. Microsatellite unstable (MSI) colorectal cancers contain a pronounced lymphocyte reaction that can pathologically identify these tumors. Colorectal tumors with elevated microsatellite alterations at selected tetranucleotide repeats (EMAST) have not been examined for lymphocyte patterns. 相似文献73.
Ayasa Matsuda Keiko Hara Miho Miyajima Eisuke Matsushima Katsuya Ohta Masato Matsuura 《Clinical neurophysiology》2013,124(6):1115-1121
Objective: The aim of the present study was to examine patterns of neural activity in response to variations in scale notes and alterations from a scale note to a non-scale note.Methods: Event-related potentials (ERPs) were recorded in response to scale and non-scale violin notes using an odd-ball mismatch negativity (MMN) paradigm. Standard stimuli were set to the scale note A4 (440 Hz). Deviant stimuli included two scale notes (scale-B, B4 = 494 Hz; scale-C, C5 = 523 Hz) and a non-scale note halfway between them (non-scale, B4 + 42¢ = 506 Hz).Results: MMN amplitude elicited by the non-scale was significantly larger than that elicited by the scale-B and scale-C, which did not differ significantly from one another.Conclusion: The current results suggest that the human brain may possess pre-attentive mechanisms for extracting relational aspects among sounds of the musical scale.Significance: The results indicate that non-scale notes may be processed in a different way even in the pre-attentive stage than scale notes. 相似文献
74.
Maki Nishimura Junko Kohara Jun Hiasa Yoshikage Muroi Naoaki Yokoyama Katsuya Kida Xuenan Xuan Hidefumi Furuoka Yoshifumi Nishikawa 《Clinical and Vaccine Immunology : CVI》2013,20(2):309-312
Histopathology and quantitative PCR (qPCR) were used to determine the tissue distribution of Neospora caninum in calves at 80 days postinfection. Our findings revealed that the most appropriate brain areas for researching N. caninum pathogenesis were the amygdala and hippocampus for qPCR and the corpus striatum and diencephalon for histopathology. 相似文献
75.
Tsuyoshi Saito Misa Ryu Yuki Fukumura Miki Asahina Atsushi Arakawa Katsuya Nakai Hiroyoshi Miura Mitsue Saito Takashi Yao 《International journal of clinical and experimental pathology》2013,6(7):1432-1436
A 70-year-old woman visited a local hospital complaining of a nodulein the right breast, present since 1 month. She was referred to our hospital for further evaluation. Following mammotome (MMT) biopsy, the nodule was diagnosed as myxoid/round cell liposarcoma. She underwent total mastectomy of the right breast. Histological analysis indicated that the tumor was almost entirely composed of proliferating small round mesenchymal cells in amyxoid matrix background with capillary-like vessels with partial necrosis (<10%). Immunohistochemically, p53 positive cells were seen focally (<1%) only, and the Ki-67 labeling index was approximately 20%. Sincethe surgical margin was histologically positive despite pathologic findings of high-grade malignancy, adjuvant treatment involving local radiation therapy (60Gy) was administered. The patient was free from any symptoms of local recurrence and metastases 1 year and 8 months after surgery. 相似文献
76.
Masayasu Aikawa Mitsuo Miyazawa Kojun Okamoto Yasuko Toshimitsu Katsuya Okada Naoe Akimoto Yosuke Ueno Isamu Koyama Yoshito Ikada 《Surgery today》2013,43(11):1298-1304
Purpose
Earlier studies have investigated the suitability of various materials and autologous grafts for the repair of diaphragmatic defects. Our group investigated the feasibility of using an artificial diaphragm (AD) to repair wide diaphragmatic defects.Methods
Twelve pigs were laparotomized and, in each pig, a defect was fashioned by resecting a round 8-cm diameter hole in the left diaphragm. Next, the defect was repaired by implanting an AD. The animals were relaparotomized 8 or 24 weeks after implantation for gross, histological and radiological observation of the implanted sites.Results
All recipient animals survived until killing for evaluation. Chest X-ray examinations showed no differences between the preoperative diaphragms and the grafted diaphragms at 8 and 24 weeks after implantation. At 8 weeks after implantation, the implanted sites exhibited fibrous adhesions to the liver and lungs without deformities or penetrations. Parts of the surface tissue at the graft sites had a varnished appearance similar to those of the native diaphragm. Histology performed at 8 weeks detected no trace of the ADs in the graft sites; however, numerous inflammatory cells and profuse fibrous connective tissue were observed. At 24 weeks after implantation, no differences were found in the thorax between the areas with the grafts and the unaffected areas. Histology of the graft sites in the thorax confirmed growth of mesothelial cells similar to that observed in the native diaphragm.Conclusions
Artificial diaphragms can be a novel substitute for diaphragmatic repair. 相似文献77.
78.
Nobuo Shinohara Takashige Abe Tango Mochizuki Akira Kashiwagi Kouichi Kanagawa Satoru Maruyama Ataru Sazawa Koji Oba Katsuya Nonomura 《Urologic oncology》2013,31(7):1276-1282
ObjectivesWe investigated the prognosis of Japanese patients with metastatic renal cell carcinoma (RCC), and analyzed the validity of Memorial Sloan-Kettering Cancer Center (MSKCC) risk classification.Materials and methodsThe endpoint of the present study was overall survival. Relationships between overall survival and potential prognostic factors were assessed using the Cox proportional hazard model with a step-wise procedure. Prognostic assessment was also performed according to the MSKCC risk classification. The predictive accuracy of the MSKCC risk classification was measured employing the concordance index.ResultsThe median survival for all patients was 22 months (95% CI, 19–28 months). The eight factors were identified as independent prognostic factor; time from initial diagnosis to metastasis, low hemoglobin (Hb), lactate dehydrogenase (LDH), corrected serum calcium (cCa), C-reactive protein (CRP), and the presence or absence of liver metastasis, bone metastasis, and lymph node metastasis. When the MSKCC risk classification was applied to patients, the median overall survival was not reached and 26 and 10 months in the patients classified as favorable, intermediate, and poor risk, respectively. The c-index was 0.73.ConclusionsThe prognosis of Japanese metastatic renal cell carcinoma patients may be better than that of previous studies from North America or Europe. Although there are some differences in the rate of patients in the risk groups and survival time by risk group between these patients, the MSKCC risk classification may be applicable for Japanese patients with metastatic renal cell carcinoma. 相似文献
79.
80.
Fukuda Yuko Yamamoto Yuka Mitamura Katsuya Ishikawa Ryo Asano Eisuke Toyohara Jun Norikane Takashi Nishiyama Yoshihiro 《Annals of nuclear medicine》2019,33(11):822-827
Annals of Nuclear Medicine - The novel radiotracer, 4′-[methyl-11C]-thiothymidine (11C-4DST), was developed based on the DNA incorporation method as a cell proliferation marker. This study... 相似文献