全文获取类型
收费全文 | 5271篇 |
免费 | 268篇 |
国内免费 | 18篇 |
学科分类
医药卫生 | 5557篇 |
出版年
2024年 | 5篇 |
2023年 | 26篇 |
2022年 | 40篇 |
2021年 | 184篇 |
2020年 | 100篇 |
2019年 | 164篇 |
2018年 | 217篇 |
2017年 | 124篇 |
2016年 | 127篇 |
2015年 | 130篇 |
2014年 | 224篇 |
2013年 | 279篇 |
2012年 | 455篇 |
2011年 | 455篇 |
2010年 | 273篇 |
2009年 | 227篇 |
2008年 | 347篇 |
2007年 | 337篇 |
2006年 | 336篇 |
2005年 | 319篇 |
2004年 | 290篇 |
2003年 | 249篇 |
2002年 | 232篇 |
2001年 | 54篇 |
2000年 | 48篇 |
1999年 | 54篇 |
1998年 | 42篇 |
1997年 | 37篇 |
1996年 | 23篇 |
1995年 | 33篇 |
1994年 | 20篇 |
1993年 | 8篇 |
1992年 | 10篇 |
1991年 | 14篇 |
1990年 | 11篇 |
1989年 | 8篇 |
1988年 | 10篇 |
1987年 | 6篇 |
1986年 | 6篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1982年 | 2篇 |
1981年 | 4篇 |
1979年 | 4篇 |
1974年 | 2篇 |
1962年 | 2篇 |
1961年 | 1篇 |
1960年 | 3篇 |
1933年 | 1篇 |
1929年 | 1篇 |
排序方式: 共有5557条查询结果,搜索用时 15 毫秒
81.
Arnau Oliver Meritxell Tortajada Xavier Lladó Jordi Freixenet Sergi Ganau Lidia Tortajada Mariona Vilagran Melcior Sentís Robert Martí 《Journal of digital imaging》2015,28(5):604-612
Breast density is a strong risk factor for breast cancer. In this paper, we present an automated approach for breast density segmentation in mammographic images based on a supervised pixel-based classification and using textural and morphological features. The objective of the paper is not only to show the feasibility of an automatic algorithm for breast density segmentation but also to prove its potential application to the study of breast density evolution in longitudinal studies. The database used here contains three complete screening examinations, acquired 2 years apart, of 130 different patients. The approach was validated by comparing manual expert annotations with automatically obtained estimations. Transversal analysis of the breast density analysis of craniocaudal (CC) and mediolateral oblique (MLO) views of both breasts acquired in the same study showed a correlation coefficient of ρ = 0.96 between the mammographic density percentage for left and right breasts, whereas a comparison of both mammographic views showed a correlation of ρ = 0.95. A longitudinal study of breast density confirmed the trend that dense tissue percentage decreases over time, although we noticed that the decrease in the ratio depends on the initial amount of breast density. 相似文献
82.
Ana Fernandez Judith Garcia-Alonso Concepción Royo-Pastor Immaculada Garrell-Corbera Jordi Rengel-Chica Josep Agudo-Ugena Alberto Ramos Juan Manuel Mendive 《The British journal of general practice》2015,65(632):e198-e203
Background
Economic recession affects quality of life by increasing rates of mental disorders in particular. Social support can be an important protective factor.Aim
To estimate the impact of being personally affected by an economic crisis on health-related quality of life (HRQoL), taking into account the possible buffering effect of perceived social support.Design and setting
Data from the first wave (March 2012 to November 2012) of the ‘Social Support and Quality of Life Study’, a longitudinal study carried out in a primary health care centre in a deprived neighbourhood of Barcelona, Spain.Method
A total of 143 participants were assessed using the 12-item Short-Form Health Survey, the List of Threatening Experiences and the Duke Social Support scales. The effect of economic crisis on mental and physical HRQoL was assessed using ordinary least squares regression models to test the interaction between social support and having experienced an economic crisis.Results
There was no statistical association between having suffered an economic crisis and physical HRQoL. The interaction between social support and economic crisis was also tested without finding any statistical association. An interaction was detected between social support and economic crisis in relation to mental HRQoL; those who had low levels of social support and had also experienced an economic crisis had the lowest levels of mental HRQoL.Conclusion
Social support constitutes a safety net that offers protection against the adverse effect of economic recessions on mental health. Primary care professionals are in a key position to promote social activities and to strengthen social networks in the community. 相似文献83.
Mercè Cladellas Jordi Bruguera Josep Comín Joan Vila Elisabeth de Jaime Julio Martí Miquel Gomez 《European heart journal》2006,27(9):1093-1099
AIMS: To assess the level of pre-operative haemoglobin (HB) as a risk marker for morbidity and mortality in the early post-operative period of patients who underwent elective valve replacement. METHODS AND RESULTS: Between January 1998 and March 2004, clinical and outcomes data were collected for the 201 patients who had elective valve replacement. For each gender, the criterion to choose the best cut-off point was that which achieved the maximum likelihood after several General Additive Model models performed in a Bootstrap procedure. The best cut-off point obtained for pre-operative HB was 12 g/dL. Overall peri-operative mortality (deaths occurring during hospital period or within 30 days) was 9.5%. After adjusting well-known independent pre-operative risk factors for operative mortality, pre-operative HB <12 g/dL was identified as an independent predictor for in-hospital mortality (OR, 3.23; 95% CI, 1.09-9.55; P = 0.03). Also adjusting for EuroScore, pre-operative HB remained significant (OR, 3.64; 95% CI, 1.32-10.06; P = 0.01). The same model was applied to post-operative morbidity, and pre-operative HB <12 g/dL was identified as an independent predictor with and without EuroScore (OR, 4.67; 95% CI, 2.03-10.71; P < 0.001), (OR, 5.18; 95% CI, 2.18-12.3; P < 0.001), respectively. CONCLUSION: In patients undergoing elective valve replacement pre-operative HB <12 g/dL is a risk marker of in-hospital mortality and serious adverse outcomes. 相似文献
84.
Wägner AM Jorba O Bonet R Ordóñez-Llanos J Pérez A 《The Journal of clinical endocrinology and metabolism》2003,88(7):3212-3217
To compare the effects of atorvastatin, gemfibrozil, and their combination on the components of diabetic dyslipidemia, 44 type 2 diabetic patients with low density lipoprotein cholesterol (LDLc) levels greater than 100 mg/dl and triglyceride levels less than 400 mg/dl were included. Twelve-week treatments with atorvastatin (10-20 mg/d) and gemfibrozil (900-1200 mg/d) were given in random order in an open, cross-over study and then combined (10 mg atorvastatin and 900 mg gemfibrozil) for 12 additional wk. Triglyceride, LDLc, high density lipoprotein cholesterol (HDLc), non-HDLc, apolipoprotein B (apoB), and LDL size were measured at baseline and after each treatment. Atorvastatin was more effective (P < 0.001) in lowering LDLc, non-HDLc, and apoB and in achieving treatment goals, whereas gemfibrozil lowered triglyceride levels more effectively (P < 0.001) and increased LDL size (from 25.59 +/- 0.06 to 25.69 +/- 0.06 nm; P < 0.05). Combined treatment with both drugs reduced LDLc, triglyceride, non-HDLc, and apoB by 26.5%, 24.1%, 30.4%, and 21.8%, respectively; increased HDLc by 4.8% and LDL size by 0.1 nm; and was the most effective treatment in reaching the therapeutic targets, especially in patients with triglyceride levels higher than 150 mg/dl. In conclusion, statins are first choice drugs in diabetic patients with low to moderate risk LDLc, although their combination with fibrates might be the most appropriate treatment, especially when triglyceride levels are above the therapeutic goal. 相似文献
85.
The Seminal Plasma of the Boar is Rich in Cytokines,with Significant Individual and Intra‐Ejaculate Variation 下载免费PDF全文
86.
Emine Alp Tuğba Tok Leylagül Kaynar Fatma Cevahir İsmail Hakkı Akbudak Kürşat Gündoğan Mustafa Çetin Jordi Rello 《Australian critical care》2018,31(6):363-368
Background
Haematological cancer (HC) patients are increasingly requiring intensive care (ICUs). The aim of this study was to investigate the outcome of HC patients in our ICU and evaluate 5 days-full support as a breakpoint for patients’ re-assessment for support.Methods
Retrospective study enrolling 112 consecutive HC adults, requiring ICU in January-December 2015. Patients’ data were collected from medical records and Infection Control Committee surveillance reports. Logistic regression analysis was performed to identify independent risk factors for ICU mortality.Results
Sixty-one were neutropenic, and 99 (88%) had infection at ICU admission. Acute myeloid leukaemia was diagnosed in 43%. Thirty-five (31%) were hematopoietic stem cell transplant recipients. Only 17 (15%) were in remission. Eighty-nine underwent mechanical ventilation on admission. Fifty-three patients acquired ICU-infection (35 bacteremia) being gram negative bacteria (Klebsiella pneumoniae and non-fermenters) the top pathogens. However, ICU-acquired infection had no impact on mortality. The overall ICU and 1-year survival rate was 27% (30 patients) and 7% (8 patients), respectively. Moreover, only 2/62 patients survived with APACHE II score ≥25. The median time for death was 4 days. APACHE II score ≥25 [OR:35.20], septic shock [OR:8.71] and respiratory failure on admission [OR:10.55] were independent risk factors for mortality in multivariate analysis. APACHE II score ≥25 was a strong indicator for poor outcome (ROC under curve 0.889).Conclusions
APACHE II score ≥25 and septic shock were criteria of ICU futility. Our findings support the full support of patients for 5 days and the need to implement a therapeutic limitations protocol. 相似文献87.
Damaskini Valvi Maribel Casas Dora Romaguera Nuria Monfort Rosa Ventura David Martinez Jordi Sunyer Martine Vrijheid 《Environmental health perspectives》2015,123(10):1022-1029
Background
Human evidence on the effects of early life phthalate exposure on obesity and cardiovascular disease risks, reported by experimental studies, is limited to a few cross-sectional studies.Objectives
We evaluated the associations between prenatal phthalate exposure and childhood growth and blood pressure in a Spanish birth cohort study.Methods
We assessed exposure using the average of two phthalate metabolite spot-urine concentrations collected from the mothers in the first and third pregnancy trimesters (creatinine-adjusted, n = 391). Study outcomes were the difference in age- and sex-specific z-scores for weight between birth and 6 months of age; and repeated age- and sex-specific z-scores for body mass index (BMI) at 1, 4, and 7 years; waist-to-height ratio at 4 and 7 years; and age- and height-specific z-scores for systolic and diastolic blood pressure at 4 and 7 years.Results
The sum of five high-molecular-weight phthalate metabolites (ΣHMWPm) was associated with lower weight z-score difference between birth and 6 months (β per doubling of exposure = –0.41; 95% CI: –0.75, –0.06) and BMI z-scores at later ages in boys (β = –0.28; 95% CI: –0.60, 0.03) and with higher weight z-score difference (β = 0.24; 95% CI: –0.16, 0.65) and BMI z-scores in girls (β = 0.30; 95% CI: –0.04, 0.64) (p for sex interaction = 0.01 and 0.05, respectively). The sum of three low-molecular-weight phthalates (ΣLMWPm) was not significantly associated with any of the growth outcomes. ΣHMWPm and ΣLMWPm were associated with lower systolic blood pressure z-scores in girls but not in boys.Conclusions
This study suggests that prenatal phthalate exposure may be associated with postnatal growth and blood pressure in a sex-specific manner. Inconsistencies with previous cross-sectional findings highlight the necessity for evaluating phthalate health effects in prospective studies.Citation
Valvi D, Casas M, Romaguera D, Monfort N, Ventura R, Martinez D, Sunyer J, Vrijheid M. 2015. Prenatal phthalate exposure and childhood growth and blood pressure: evidence from the Spanish INMA-Sabadell birth cohort study. Environ Health Perspect 123:1022–1029; http://dx.doi.org/10.1289/ehp.1408887 相似文献88.
89.
Jordi Landier Guillaume Constantin de Magny Andres Garchitorena Jean-Fran?ois Guégan Jean Gaudart Laurent Marsollier Philippe Le Gall Tamara Giles-Vernick Sara Eyangoh Arnaud Fontanet Ga?tan Texier 《Emerging infectious diseases》2015,21(8):1414-1417
To determine when risk for Buruli ulcer is highest, we examined seasonal patterns in a highly disease-endemic area of Cameroon during 2002–2012. Cases peaked in March, suggesting that risk is highest during the high rainy season. During and after this season, populations should increase protective behaviors, and case detection efforts should be intensified. 相似文献
90.
Iris?Iglesia Isabelle?Guelinckx Pilar?M.?De?Miguel-Etayo Esther?M.?González-Gil Jordi?Salas-Salvadó Stavros?A.?Kavouras Joan?Gandy Homero?Martínez Saptawati?Bardosono Morteza?Abdollahi Esmat?Nasseri Agnieszka?Jarosz Guansheng?Ma Esteban?Carmuega Isabelle?Thiébaut Luis?A.?MorenoEmail author 《European journal of nutrition》2015,54(2):57-67