全文获取类型
收费全文 | 280篇 |
免费 | 26篇 |
学科分类
医药卫生 | 306篇 |
出版年
2022年 | 1篇 |
2021年 | 6篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 8篇 |
2017年 | 9篇 |
2016年 | 10篇 |
2015年 | 11篇 |
2014年 | 13篇 |
2013年 | 20篇 |
2012年 | 18篇 |
2011年 | 16篇 |
2010年 | 11篇 |
2009年 | 4篇 |
2008年 | 16篇 |
2007年 | 10篇 |
2006年 | 17篇 |
2005年 | 14篇 |
2004年 | 16篇 |
2003年 | 14篇 |
2002年 | 17篇 |
2001年 | 11篇 |
2000年 | 5篇 |
1999年 | 6篇 |
1998年 | 3篇 |
1997年 | 2篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 3篇 |
1990年 | 3篇 |
1989年 | 2篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1975年 | 2篇 |
1964年 | 1篇 |
1962年 | 1篇 |
1931年 | 1篇 |
1901年 | 2篇 |
1897年 | 1篇 |
1895年 | 1篇 |
1892年 | 1篇 |
1891年 | 1篇 |
1888年 | 1篇 |
排序方式: 共有306条查询结果,搜索用时 218 毫秒
301.
302.
Tsirigotis P Kapsimalli V Baltadakis I Kaloyannidis P Karakasis D Papalexandri A Psarra E Nosi E Konsta E Vikentiou M Papageorgiou S Sakellari I Pappa V Harhalakis N Anagnostopoulos A Dervenoulas J 《Transfusion and apheresis science》2012,46(2):181-188
Extracorporeal photopheresis (ECP) has been established as an effective treatment modality for patients with chronic extensive graft-versus host disease (GVHD). In the present study, we evaluated the influence of ECP on the numbers of CD4+, CD8+, CD20+, CD56+ cells, and on T-regulatory (Tregs), as well as on the numbers of naïve, central memory (CM), and effector memory (EM) T-cells in patients treated for refractory chronic GVHD. Flow cytometric analysis of peripheral blood lymphocytes was performed for the calculation of the different T-cell subsets. Patients with GVHD had a higher percentage of EM-CD4+ cells in comparison with healthy donors (p = 0.046). The percentages of naïve-CD8+, naïve-CD4+, CM-CD8+, CM-CD4+, EM-CD8+, and Tregs were not different between patients with GVHD and healthy donors. Similarly there was no statistical difference in the percentages of naïve, CM, and EM CD4+ and CD8+ cells before and after 3 months of treatment with ECP. However, in the subset of Tregs a statistically significant increase was observed after 3 months of treatment with ECP (p = 0.015). Responders to ECP had statistically significantly higher absolute numbers of CD4+, and CD8+ cells, in comparison with non-responders. These data further support the concept that ECP does not cause immune-suppression, but should be better considered as an immune-modulating treatment. 相似文献
303.
304.
305.
Siakantaris MP Tsirigotis P Stavroyianni N Argyropoulos KV Girkas K Pappa V Chondropoulos S Papadavid E Sakellari I Anagnostopoulos A Antoniou C Dervenoulas J 《Transfusion and apheresis science》2012,46(2):189-193
Extracorporeal photopheresis (ECP) is an established therapy for cutaneous T-cell lymphoma (CTCL). The objective of this study was to further explore the clinical efficacy of ECP combined with immunomodulatory agents. Eighteen patients with histologically proven CTCL were followed-up after therapy with ECP, mainly combined with interferon-α or bexarotene. A total of 61% of patients responded to therapy (n=11; CR: 5, PR: 6). Median survival was 51 months, progression free survival was 28 months and response duration was 29 ± 23.9 months. ECP combined therapy was highly effective or had a palliative effect in CTCL resistant to previous treatments. 相似文献
306.
D Gray N Y Parker-Cohen T White S T Clark S H Seiner J Achilles W M McMahon 《Journal of developmental and behavioral pediatrics : JDBP》2001,22(4):234-242
Chronic fatigue syndrome (CFS) is a controversial diagnosis with unknown cause. Adult studies indicate high rates of psychosocial dysfunction and psychiatric comorbidity. The authors compared three groups of pediatric patients selected by diagnosis-(1l) CFS (n = 15), (2) juvenile rheumatoid arthritis (n = 15), and (3) mood disorders (n = 15)-across many psychological measures. CFS subjects had dramatic elevation of the Somatic Complaints subscale (mean T score = 75), whereas the mood disorders group had higher externalizing scores (mean T score = 68) on the Child Behavior Checklist. The CFS subjects missed significantly more school compared with the two control groups. After the onset of CFS, 13 of 15 of the CFS patients required significant educational accommodation. Only 4 of the 15 CFS patients had an Axis I psychiatric diagnosis, as determined by the Computerized Diagnostic Interview for Children. Despite a low rate of psychiatric diagnosis in the CFS sample, these data attest to their psychosocial and school dysfunction. 相似文献