5-二茂铁基噁唑的合成研究

以二茂铁甲醛和对甲苯磺酰基异氰(TOSMIC)为原料,经过Van Leusen反应,一步合成目标化合物5-二茂铁基噁唑,通过~1HNMR、~(13)CNMR和ESI-MS对其结构进行表征,并对影响收率的主要因素进行考察。结果表明,在物料比n(TOSMIC)∶n(二茂铁甲醛)为1.1∶1、反应溶剂为甲醇、K_2CO_3用量即n(K_2CO_3)∶n(二茂铁甲醛)为2.0∶1、反应温度为65℃、反应时间为8 h的最佳条件下,目标化合物收率达到74.7%。该方法具有原料廉价易得、反应操作简单、收率高等优点,具有一定的应用价值。     

Formation of a protective layer against corrosion on Mg alloy via alkali pretreatment followed by vanillic acid treatment

Although Mg alloy possesses high specific strength, low density, and good biocompatibility, poor corrosion resistance hinders its further applications. In the present study, an innovative protective layer against corrosion was prepared on the AZ31 Mg alloy via alkali pretreatment followed by vanillic acid treatment. The alkali pretreatment supplied –OH for the AZ31 Mg alloy surface to react with vanillic acid. The vanillic acid treatment played a crucial role in enhancing the corrosion resistance due to the excellent ability to act as a barrier and retard aqueous solution penetration, which effectively isolated the underlying Mg alloy from the corrosive environment. The corrosion current density of alkali and vanillic acid-treated Mg alloy (AZ31V) almost showed two orders of magnitude lower values in comparison with that of the AZ31 Mg alloy, and the corrosion potential of AZ31V Mg alloy increased from −1.41 to −1.25 V. The immersion tests proved that there was no occurrence of severe corrosion. Hence, the alkali pretreatment and vanillic acid treatment may represent a promising method to improve the corrosion resistance of Mg alloy.     

轮胎外轮廓对气动阻力影响的研究

针对185/65R14乘用车轮胎，采用流体动力学计算方法，研究轮胎外轮廓对轮胎气动阻力的影响。结果表明：轮胎外轮廓对轮胎气动阻力因数影响明显，轮胎气动阻力因数的差异最大可达14.51%；通过改进影响气流分离的轮胎外轮廓，可以减小气流尾涡以降低轮胎气动阻力。本研究结果可为低气动阻力轮胎结构设计奠定基础。     

一种大型复杂构件加工新模式及新装备探讨

大型复杂构件是航空航天、能源、船舶等领域装备的核心结构件，此类构件通常具有尺寸大、形状复杂、刚性弱等特点。传统“分体离线加工-在线检测”模式存在工艺不稳定、过程复杂、柔性差、周期长等问题，以龙门式多轴数控机床加工为代表的“包容式”加工模式，难以适应大型复杂构件的高效高质量加工制造需求。提出一种基于移动式和吸附式机器人的多机协同原位加工新模式，通过多机器人系统自主寻位、精确定位加工与加工质量原位检测，实现大型复杂构件多安装面并行铣削、制孔与打磨等作业。多机器人系统包括移动式混联机器人、吸附式并联机器人、移动式串联铣削机器人、移动式双臂加工机器人和移动式打磨机器人。构建多机协同原位加工模式，需要揭示多机器人协同原位加工行为与大型弱刚性结构件质量控制的交互机理，面临着本体、测量、工艺和集成四个方面的挑战，需要设计高灵活、高刚度的移动式和吸附式加工机器人，解决移动机器人自主准确寻位和超大结构件原位高精检测难题，攻克加工变形误差在线补偿和振动抑制技术，通过集成实现多机协同高效高精加工，为大型复杂构件的高效高质量制造提供创新技术及装备，并实现此类构件制造核心技术及装备自主可控。     

Coexistence of three ferroelectric phases and enhanced piezoelectric properties in BaTiO3–CaHfO3 lead-free ceramics

Perovskite ferroelectrics possess the fascinating piezoelectric properties near a morphotropic phase boundary, attributing to a low energy barrier that the results in structural instability and easy polarization rotation. In this work, a new lead-free system of (1-x)BaTiO₃-xCaHfO₃ was designed, and characterized by a coexistence of ferroelectric rhombohedral-orthorhombic-tetragonal (R-O-T) phases. With the increase amount of CaHfO₃ (x), a stable coexistence region of three ferroelectric phases (R-O-T) exists at 0.06 ≤ x ≤ 0.08. Both large piezoelectric coefficient (d₃₃～400 pC/N), inverse piezoelectric coefficient (d₃₃^*～547 pm/V) and planar electromechanical coupling factor (k_p～58.2%) can be achieved for the composition with x = 0.08 near the coexistence of three ferroelectric phases. Our results show that the materials with the composition located at a region where the three ferroelectric R-O-T phases coexist would have the lowest energy barrier and thus greatly promote the polarization rotation, resulting in a strong piezoelectric response.     

Application of Mono‐ and Disaccharides in Drug Targeting and Efficacy

Carbohydrates and their conjugates play important roles in many biological processes including fertilization, differentiation, development, immune response, and infection. Their activities are largely dependent on the properties of terminal mono‐ or disaccharides. Galactose, mannose, fucose, glucose, sialic acid, etc., are commonly used as powerful scaffolds installed on drug molecules for targeting specific tissues including brain, liver, and cancers, and as epitopes for enhancing the targeting of various vaccines. This review focuses on the influence of their structural variations, including changes in sugar type, substituent groups and their positions, as well as length of linker portion, on the targeting of drugs or their efficacy. Particular attention is paid to the targeting properties of mono‐ and disaccharides applied in drug design and discovery.     

Operating Range Scheduled Robust Dahlin Algorithm to Typical Industrial Process with Input Constraint

International Journal of Control, Automation and Systems - There is a class of typical nonlinear industrial process, which can be characterized by a first-order inertia plus pure delay model in an...     

空间红外大口径折射式低温镜头设计与验证

针对目标探测类空间红外相机大范围成像、高灵敏度探测、高精度定位等应用需求,文中提出采用像方远心光路和低温光学技术结合的解决方案,设计了物方视场角8°×8°、入瞳口径265 mm、工作温度200 K的像方远心折射式光学系统。镜头最大口径280 mm,采用多级分散的弹性支撑设计,解决大口径低温透镜装框、透镜组件支撑和镜头整体安装各环节的热应力卸载问题。在保证高刚度和低漏热的情况下,使低温下透镜的热应力对镜头能量集中度的影响降低到可接受范围内。镜头完成装调及室温下像质确认后,进行了力学振动试验,并将其制冷到200 K水平测试像质,测试结果表明,镜头能量集中度达到轴上75%,边缘视场72%。