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31.
Luiza Ghila Thomas Aga Legy Andreas Frslev Mathisen Shadab Abadpour Joao A. Paulo Hanne Scholz Helge Rder Simona Chera 《International journal of molecular sciences》2021,22(7)
The past decade revealed that cell identity changes, such as dedifferentiation or transdifferentiation, accompany the insulin-producing β-cell decay in most diabetes conditions. Mapping and controlling the mechanisms governing these processes is, thus, extremely valuable for managing the disease progression. Extracellular glucose is known to influence cell identity by impacting the redox balance. Here, we use global proteomics and pathway analysis to map the response of differentiating human pancreatic progenitors to chronically increased in vitro glucose levels. We show that exogenous high glucose levels impact different protein subsets in a concentration-dependent manner. In contrast, regardless of concentration, glucose elicits an antipodal effect on the proteome landscape, inducing both beneficial and detrimental changes in regard to achieving the desired islet cell fingerprint. Furthermore, we identified that only a subgroup of these effects and pathways are regulated by changes in redox balance. Our study highlights a complex effect of exogenous glucose on differentiating pancreas progenitors characterized by a distinct proteome signature. 相似文献
32.
33.
Tracy Q. Gardner Ana I. Flores Richard D. Noble John L. Falconer 《American Institute of Chemical Engineers》2002,48(6):1155-1167
A transient permeation method presented here not only determines the adsorption and diffusion properties of the pores that are the transport pathways through zeolite membranes, but nondestructively estimates the effective thickness of the membrane. Transient responses of the permeate concentration to step changes in the feed were measured on two H-ZSM-5 tubular membranes and modeled assuming Maxwell-Stefan diffusion and Langmuir adsorption. The adsorption isotherms determined from these transient measurements at 298 K of N2 and CO2 were nearly identical to those measured by calorimetry on H-ZSM-5 powders. The CH4 isotherm at 298 K was similar to isotherms measured by calorimetry and gravimetric techniques on Na-ZSM-5 and silicalite powders. The similarity of the isotherms indicates that transport of these light gases occurs mainly through zeolite pores. The Maxwell-Stefan diffusion coefficients DMS depended on concentration and were higher for higher feed partial pressures. Average DMS values for the two membranes were 7.5, 5 and 1.5×10−10 m2/s for N2, CH4, and CO2, respectively; these are in the same range and order as diffusion coefficients measured in zeolite crystals. 相似文献
34.
Clinical practice guidelines in paper format are still the preferred form of delivery of medical knowledge and recommendations to healthcare professionals. Their current support and development process have well identified limitations to which the healthcare community has been continuously searching solutions. Artificial intelligence may create the conditions and provide the tools to address many, if not all, of these limitations.. This paper presents a comprehensive and up to date review of computer-interpretable guideline approaches, namely Arden Syntax, GLIF, PROforma, Asbru, GLARE and SAGE. It also provides an assessment of how well these approaches respond to the challenges posed by paper-based guidelines and addresses topics of Artificial intelligence that could provide a solution to the shortcomings of clinical guidelines. Among the topics addressed by this paper are expert systems, case-based reasoning, medical ontologies and reasoning under uncertainty, with a special focus on methodologies for assessing quality of information when managing incomplete information. Finally, an analysis is made of the fundamental requirements of a guideline model and the importance that standard terminologies and models for clinical data have in the semantic and syntactic interoperability between a guideline execution engine and the software tools used in clinical settings. It is also proposed a line of research that includes the development of an ontology for clinical practice guidelines and a decision model for a guideline-based expert system that manages non-compliance with clinical guidelines and uncertainty. 相似文献
35.
Hipolito Aguilar-Sierra Gerardo Flores Sergio Salazar Rogelio Lozano 《Journal of Intelligent and Robotic Systems》2014,73(1-4):455-468
This work addresses the problem of fault detection and diagnosis (FDD) for a quad-rotor mini air vehicle (MAV). Actuator faults are considered on this paper. The basic idea behind the proposed method is to estimate the faults signals using the extended state observers theory. To estimate the faults, a polynomial observer (Aguilar et al. 2011; Mata-Machuca et al., Commun Nonlinear Sci Numer Simul 15(12):4114–4130, 2010, BioSystems 100(1):65–69, 2010) is presented by using the available measurements and know inputs of the system. In order to investigate the diagnosability properties of the system, a differential algebra approach is proposed (Cruz-Victoria et al., J Frankl Inst 345(2):102–118, 2008; and Martinez-Guerra and Diop, IEE P-Contr Theor Ap 151(1):130–135, 2004). The effectiveness of the methodology is illustrated by means of numerical simulations. 相似文献
36.
Inductive Model Generation for Text Classification Using a Bipartite Heterogeneous Network
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Rafael Geraldeli Rossi Alneu de Andrade Lopes Thiago de Paulo Faleiros Solange Oliveira Rezende 《计算机科学技术学报》2014,(3):361-375
Algorithms for numeric data classification have been applied for text classification. Usually the vector space model is used to represent text collections. The characteristics of this representation such as sparsity and high dimensionality sometimes impair the quality of general-purpose classifiers. Networks can be used to represent text collections, avoiding the high sparsity and allowing to model relationships among different objects that compose a text collection. Such network- based representations can improve the quality of the classification results. One of the simplest ways to represent textual collections by a network is through a bipartite heterogeneous network, which is composed of objects that represent the documents connected to objects that represent the terms. Heterogeneous bipartite networks do not require computation of similarities or relations among the objects and can be used to model any type of text collection. Due to the advantages of representing text collections through bipartite heterogeneous networks, in this article we present a text classifier which builds a classification model using the structure of a bipartite heterogeneous network. Such an algorithm, referred to as IMBHN (Inductive Model Based on Bipartite Heterogeneous Network), induces a classification model assigning weights to objects that represent the terms for each class of the text collection. An empirical evaluation using a large amount of text collections from different domains shows that the proposed IMBHN algorithm produces significantly better results than k-NN, C4.5, SVM, and Naive Bayes algorithms. 相似文献
37.
We address the problem of robust and efficient treatment of element collapse and inversion in corotational FEM simulations of deformable objects in two and three dimensions, and show that existing degeneration treatment methods have previously unreported flaws that seriously threaten robustness and physical plausibility in interactive applications. We propose a new method that avoids such flaws, yields faster and smoother degeneration recovery and extends the range of well‐behaved degenerate configurations without adding significant complexity or computational cost to standard explicit and quasi‐implicit solvers. 相似文献
38.
F. Figueras J. L. Flores G. Delahay A. Bourane J.-M. Clacens A. Desmartin-Chomel B. Coq A. Giroir-Fendler 《Topics in Catalysis》2006,39(1-2):59-64
Titanias of different surface areas have been sulfated and used as supports of Rh oxide for the selective catalytic reduction
of nitrogen oxides. Only the sulfation of TiO2 of large surface areas gives strong Br?nsted acid sites, retaining pyridine up to 773 K. Low surface area anatase is unable
to retain sulfates. The catalytic activities measured at 523 K, increase with the number of acid sites, and then reach a plateau,
showing the intervention of acidity in the SCR. This is true only for Rh but not for Pt. The investigation of the elemental
steps on Rh/sulfated TiO2 by in situ diffuse reflectance spectroscopy permits to clarify a few points: the oxidation of propene, presumably to acetaldehyde, occurs
by the reaction with nitrates adsorbed on the support. The further oxidation of this intermediate by NO2 yields an isocyanate, which can be hydrolysed to ammonia. 相似文献
39.
This article introduces a new method for model falsification using set‐valued observers, which can be applied to a class of discrete linear time‐invariant dynamic systems with time‐varying model uncertainties. In comparison with previous results, the main advantages of this approach are as follows: The computation of the convex hull of the set‐valued estimates of the state can be avoided under certain circumstances; to guarantee convergence of the set‐valued estimates of the state, the required number of previous steps is at most as large as the number of states of the nominal plant; and it provides a straightforward nonconservative method to falsify uncertain models of dynamic systems, including open‐loop unstable plants. The results obtained are illustrated in simulation, emphasizing the advantages and shortcomings of the suggested method. Copyright © 2013 John Wiley & Sons, Ltd. 相似文献
40.
Ritesh Rawal Antonio Feteira Alberto Arenas Flores Neil C. Hyatt Anthony R. West Derek C. Sinclair Kumaravinothan Sarma Neil McN. Alford 《Journal of the American Ceramic Society》2006,89(1):336-339
The dielectric properties of dense ceramics of the "twinned" 8H-hexagonal perovskite Ba8 Nb4 Ti3 O24 are reported. Single-phase powders were obtained from the mixed-oxide route at 1325°C and ceramics (>92% of the theoretical X-ray density) by sintering in air or flowing O2 at 1400°–1450°C. The ceramics are dc insulators with a band gap >3.4 eV that resonate at microwave frequencies with relative permittivity, ɛr ∼44–48, quality factor, Q × f r ∼21 000–23 500 GHz (at f r ∼5.5 GHz) and temperature coefficient of resonant frequency, TC f ,∼+115 ppm/K. 相似文献