Preparation and characterization of novel derivatives of chitosan and trimethyl chitosan conjugated with dipeptides and vitamin B12 as candidates for oral delivery of insulin

Chitosan and its derivatives are widely used in drug delivery systems due to their bio-degradebility, bio-compatibility and absorption enhancing properties. Many peptide and protein derived therapeutics cannot be administered through oral rout because of the proteolytic condition of gastro-intestinal tract and their low bio-availability. Insulin is a peptide drug which is widely used in diabetics as repeated daily injection. Due to the fact that there are receptors for didpeptides and vitamine B12 in small intestine, in this research work novel derivatives of chitosan and trimethyl chitosan conjugated with glycyl-glycine, alanyl-alaninie and vitamine B12 were synthesized and characterized. The structure of conjugates as well as substitution of different functional groups was confirmed by different instrumental analytical methods such as Fourier transform infrared, magnetic resonance, and X-ray diffraction spectroscopy. Nano-particles of aforementioned loaded with insulin were prepared and their size, surface electrical charge and morphology characterized and their release profile were studied. The results are promising and reveal that these new chitosan and trimethyl chitosan derivatives are potential vehicles for protein and peptide drug molecules.     

Comparison of bolted end plate and T-stub connections sensitivity to bolt diameter on cyclic behavior

Considering the construction limitations, proper and correct design of connections is vital and of great importance. At the construction stage, it is probable to use a connection bolt with a diameter less than the design assumptions. It can occur due to an imperfection in construction or even to changes in the function of the building. The unforeseen changes can increase the structural load, and consequently the moment and shear force demand values. Therefore, the present paper is aimed to examine the sensitivity of the bolted connections to the diameter of bolts using a numerical method. The results show that bolted T-stub connections are more sensitive to bolt diameter than end plate connections. Hence, the bolted end plate connections are recommended where the imperfection in construction or changes in function of the building is probable. Moreover, in construction of bolted connections, if changing the number of bolts regarding the constant total cross sectional area is considered, it is recommended to use the symmetric arrangement of bolts on each beam flange. In design of connections for a particular frame according to AISC, the moment capacity of T-stub connection is higher than that of end plate connection. However, the total energy absorptions of these connection types are approximately equal.     

A Novel Evolutionary-Based Cooperative Spectrum Sensing Mechanism for Cognitive Radio Networks

Cognitive radio (CR) is considered as a feasible intelligent technology for 4G wireless networks or self-organization networks and envisioned as a promising paradigm of exploiting intelligence for enhancing efficiency of underutilized spectrum bands. In CR, one of the main concerns is to reliably sense the presence of primary users, to attain protection against harmful interference caused by the potential spectrum access of secondary users (SUs). In this paper, evolutionary algorithms, namely, genetic algorithm (GA) and particle swarm optimization (PSO) are investigated. An imperialistic competitive algorithm (ICA) is proposed to minimize error detection at the common soft data fusion (SDF) center for structurally centralized cognitive radio network (CRN). By using these techniques, evolutionary operations are invoked to optimize the weighting coefficients applied on the sensing measurement components received from multiple cooperative SUs. The proposed method is compared with other evolutionary algorithms, as well as other conventional deterministic, such as maximal ratio combining- (MRC-), modified deflection coefficient- (MDC-), normal deflection coefficient- (NDC-) based SDF schemes and OR-rule HDF based. MATLAB simulations confirm the superiority of the ICA-based scheme over the PSO-, GA-based and other conventional schemes in terms of detection performance. In addition, the ICA-based scheme also shows promising convergence and time running performance as compared to other iterative-based schemes. This makes ICA an adequate solution to meet real-time requirements.     

Harmony search optimization algorithm for a novel transportation problem in a consolidation network

This article presents a new harmony search optimization algorithm to solve a novel integer programming model developed for a consolidation network. In this network, a set of vehicles is used to transport goods from suppliers to their corresponding customers via two transportation systems: direct shipment and milk run logistics. The objective of this problem is to minimize the total shipping cost in the network, so it tries to reduce the number of required vehicles using an efficient vehicle routing strategy in the solution approach. Solving several numerical examples confirms that the proposed solution approach based on the harmony search algorithm performs much better than CPLEX in reducing both the shipping cost in the network and computational time requirement, especially for realistic size problem instances.     

Dual-Rotation Speed Friction Stir Welding: Experimentation and Modeling

Implementing differential rotation speeds of pin and shoulder in the friction stir welding process is considered. Experimental investigations were carried out using a newly designed and fabricated apparatus for dual-rotation speed friction stir welding. Metallographic studies demonstrated that appropriate selection of separate pin and the shoulder rotation speeds not only results in defect-free joints, but also affects the weld zone by controlling the heat input delivered. An energy model for predicting maximum temperature was extended to the dual-rotation speed friction stir process. The model was verified using the previous experimental results reported in the literature.     

Improving the quality of surface in polishing process with the magnetic abrasive powder polishing (MAPP) by use of ultrasonic oscillation of work-piece on a CNC table

In this research work, polishing inside, outside and over the cylindrical parts has been done by using a completely new and innovative method. The work-pieces have been placed on a two-axis Cartesian CNC Table for polishing operations. The Magnetic Rotary Head continuously changes its rotation direction from CW to CCW and CCW to CW and meanwhile the part begin to oscillate up-and-down under a High Frequency (20 kHz) conditions. The Frequency of changing direction From CW to CCW and CCW to CW is one of the important parameters in this method. This method is a kind of Ultrasonic Assisted Polishing (UAP) and novelty of this research work is combining this method with motion of work piece under CNC trajectory with continuously changing direction of Magnetic Rotary Head. Gap between Rotary Magnetic Polishing Head and the Work piece Surface can be controlled by a power transmission screw which operates in the direction of the vertical axis. Several experiments have proved high performance of this new proposed method in the process of polishing in short times.     

Analytical solution for transient temperature and thermal stresses within convective multilayer disks with time-dependent internal heat generation,Part II: Applications

This work investigates the analytical solution for transient temperature and thermal stresses within three circular geometries. First, the transient temperature and thermal stresses within a composite disk are addressed. Then, two examples regarding transient temperature and thermal stresses throughout circular heaters are analyzed. Pulsed and sinusoidal internal heat generations are incorporated into the second and third examples, respectively. For the composite hollow-disk example, merely the separation of variables method (SVM) is used to overcome the energy partial differential equation. For the other two examples, the combination of the SVM and Duhamel's theorem are adopted to solve the partial differential equations. Accordingly, assuming plane stress formulation, the transient thermal stresses within structures are obtained.     

Application of titanium oxide nanotube films containing gold nanoparticles for the electroanalytical determination of ascorbic acid

Au/TiO₂/Ti electrodes have been prepared by galvanic deposition of gold particles on TiO₂ nanotube substrates. Titanium oxide nanotubes are fabricated by anodizing titanium foil in a Dimethyl Sulfoxide electrolyte containing fluoride. The scanning electron microscopy results indicated that gold particles are homogeneously deposited on the surface of TiO₂ nanotubes. The TiO₂ layers consist of individual tubes of about 40-80 nm diameters. The electro-catalytic behavior of Au/TiO₂/Ti and flat gold electrodes for the ascorbic acid electro-oxidation was studied by cyclic voltammetry. The results showed that the flat gold electrode is not suitable for the oxidation of ascorbic acid. However, the Au/TiO₂/Ti electrodes are shown to possess catalytic activity toward the oxidation reaction. Catalytic oxidation peak current showed a linear dependence on the ascorbic acid concentration and a linear calibration curve is obtained in the concentration range of 1-5 mM of ascorbic acid. Also, determination of ascorbic acid in real samples was evaluated. The obtained results were found to be satisfactory. Finally the effects of interference on the detection of ascorbic acid were investigated.     

On the formulation design and rheological evaluations of pectin-based functional gels

In the current study, formulation design and development of a novel pectin-based functional gel were investigated. Amidated low methoxyl pectin (ALMP), high methoxyl pectin (HMP), sorbitol, inulin, rebaudioside-A, gardenia, phloridzin, quercetin, apple flavor, and calcium chloride (as its dihydrated salt) were selected as general ingredients. Response surface methodology was applied to design different formulations and to investigate on their experimental responses. The oscillatory tests were carried out in 2 stages with ALMP, HMP, sorbitol, and inulin as the variables of the 1st stage and ALMP and calcium chloride as the variables of the 2nd stage. Results of the 1st stage indicated relatively similar behaviors throughout the frequency range applied for all of the samples studied (true gels). However, magnitudes of the 5 rheological parameters of this study (storage modulus, loss modulus, loss tangent, complex modulus, and complex viscosity) were affected by different variables (ALMP, HMP, inulin, and sorbitol concentrations). Experimental results confirmed that sorbitol could be omitted from the formula while inulin and HMP could be used at their highest levels studied. At the 2nd stage, only 2 formulas indicated a strong gel behavior and other formulas showed typical behaviors of weaker gels or those of the concentrated solutions. At the conclusion of this study, a finished gelled product formula was suggested with the application of the best levels of the ingredients. The resultant gel was found to be set rapidly with no syneresis and showed a potential to be considered as a functional gelled dessert.