Sol-Gel Glass-Encapsulated Crown Ethers for the Separation and Preconcentration of Strontium from Acidic Media

Extraction chromatography employing an inert polymeric support impregnated with a crown ether (typically, 4,4’,(5’)-di-(tert-butylcyclohexano)-18-crown-6 (DtBuCH18C6)), either neat (i.e., undiluted) or as a solution in 1-octanol, has previously been shown to provide an effective means for the isolation of radiostrontium from a variety of sample types for subsequent determination. In this study, sol-gel chemistry has been employed to prepare sorbents in which DtBuCH18C6 is encapsulated in a silica matrix. The resultant materials have been evaluated for their ability to retain strontium ion and compared to a commercially available extraction chromatographic (EXC) resin. Certain of the new materials are shown to provide uptake efficiencies comparable to those obtained with the commercial resins, although unless a porogen is employed, the kinetics of strontium uptake are significantly slower. In contrast to conventional EXC materials, however, strontium uptake by DtBuCH18C6-loaded glasses does not increase in proportion to the amount of extractant present, indicating that not all of the crown ether present is available for interaction with the metal ion.     

Dynamics of incomplete ionized dopants and their impact on4H/6H-SiC devices

The influence of incomplete ionization of dopants in 4H/6H-SiC on transient device behavior has been investigated numerically based on a self-consistent solution of the coupled system of Poisson's equation, the continuity equations of electrons and holes, and balance equations for each donor or acceptor level. If the rise time of a reverse bias pulse is equal or smaller than the characteristic ionization time constant, a dynamically enlarged extension of depletion regions is obtained which can result in a dynamic punchthrough (PT) within back-to-back junction configurations. The respective time constants of nitrogen (N), aluminum (Al), and boron (B) mere measured as functions of temperature in 4H- and 6H-SiC using thermal admittance spectroscopy (AS) and deep level transient spectroscopy (DLTS). At room temperature, for instance, we obtained 60 ps/2 ps, 300 ps/10 ps, and 100 ns/100 ns for N (cubic site), Al, and B in 4H/6H-SiC, respectively. As the time constants of N and Al are small, transient incomplete ionization turns out to be negligible, at least within today's high-power device operation areas. Boron, on the other hand, influences significantly the dynamic device characteristics. In order to demonstrate the implications of these effects, numerical device simulations of a 6H-SiC double-implanted MOSFET and a 4H-SiC thyristor were performed. These simulations allow a detailed analysis of the transient device behavior and the onset of dynamic PT which strongly depends on temperature, structure parameters, and the external excitation     

Thermo-reversible sol–gel transition of TiO2 nanoparticles with surface modified by p-toluene sulfonic acid

In this paper an unprecedent thermo-reversible sol–gel transition for titania nanoparticles dispersed in a solution of p-toluene sulfonic acid (PTSH) in isopropanol is reported. The sol formed by the thermo-hydrolysis at 60 °C of titanium tetraisopropoxide (Ti(OⁱPr)₄) reversibly changes into a turbid gel upon cooling to room temperature. Turbidimetric measurements performed for samples containing different nominal acidity ratios (A = [PTSH]/[Ti]) have evidenced that the gel transformation temperature increases from 20 to 35 °C as the [PTSH]/[Ti] ratio increases from 0.2 to 2.0. SAXS results indicate that the thermo-reversible gelation is associated to a reversible aggregation of a monodisperse set of titania nanoparticles with average gyration radius of ≈2 nm. From the different PTSH species evidenced by Raman spectroscopy and TG/DTA of dried gels we proposed that the thermo-reversible gelation in this systems is induced by the formation of a supramolecular network, in which the protonated surface of nanoparticles is interconnected through cooperative hydrogen bonds between –SO₃ groups of p-toluene sulfonic acid.     

Intratumoral microdistribution of [131I]MB-1 in patients with B-cell lymphoma following radioimmunotherapy

Leprechaunism is a rare autosomal recessive disorder characterized by marked intrauterine and postnatal growth retardation, severe insulin resistance, and altered glucose homeostasis. This syndrome is related to mutations in the insulin receptor (IR) gene that impair the transmission of the insulin signal by several mechanisms. There is no effective therapy and patients usually die within the first months of life. Here we report the prenatal diagnosis of leprechaunism in two unrelated families in which affected children were compound heterozygotes with two different deficient IR alleles. In family Par-1, the disease IR alleles carried a missense mutation located in exon 18 (Arg1092-->Trp) and exon 20 (Glu1179-->Lys). In family Als, a 3-basepair deletion causing the loss of Asn281 in exon 3 and a major deletion of exons 10-13 were present in the maternal and paternal mutant IR alleles, respectively. Prenatal diagnosis was made in each family by a specific approach combining denaturing gradient gel electrophoresis (DGGE) and Southern blotting. This methodology allowed us to correctly predict the genotype of the two fetuses at the IR locus.     

The polypyrimidine tract binding protein (PTB) requirement for internal initiation of translation of cardiovirus RNAs is conditional rather than absolute

Picornavirus RNAs are translated by an unusual mechanism of internal ribosome entry that requires a substantial segment of the viral 5'-untranslated region, generally known as the internal ribosome entry segment (IRES), and in some circumstances may require cellular trans-acting proteins, particularly polypyrimidine tract binding protein (PTB). It is shown here that for encephalomyocarditis virus (EMCV), the PTB dependence of IRES function in vitro is determined partly by the nature of the reporter cistron, and more especially by the size of an A-rich bulge in the IRES. With a wild-type EMCV IRES (which has a bulge of 6 As), translation is effectively independent of PTB provided the IRES is driving the synthesis of EMCV viral polyprotein. With an enlarged (7A) bulge and heterologous reporters, translation is highly dependent on PTB. Intermediate levels of PTB dependence are seen with a 7A bulge IRES driving viral polyprotein synthesis or a wild-type (6A) bulge IRES linked to a heterologous reporter. None of these parameters influenced the binding of PTB to the high-affinity site in the IRES. These results argue that PTB is not an essential and universal internal initiation factor, but, rather, that when it is required, its binding to the IRES helps to maintain the appropriate higher-order structure and to reverse distortions caused, for example, by an enlarged A-rich bulge.     

Temperature dependence of the coefficient of linear thermal expansion of single-crystal SmS

The coefficient of linear thermal expansion of single-crystal SmS has been measured in the temperature range 300–850 K by dilatometry and X-ray diffraction. It is shown that the difference in the results obtained by these two methods is due to the heating-induced formation of SmS phases with small lattice parameters (5.62–5.8 Å) close to that for the metallic SmS phase.     

Breast feeding at maternity hospitals in France in 1995. National perinatal survey

The objectives of the study were to estimate the current level of breast-feeding at hospital discharge in France, and to identify maternal factors and characteristics of the pregnancy and delivery associated with breast-feeding. DATA AND METHODS: The sample included all births during 1 week in France in 1995 (n = 12,179 babies). The data were collected during the postnatal stay in hospital. Factors associated with breast-feeding were identified, using bivariate analysis and multiple logistic regression. As the relations between the studied factors and breast-feeding differed between French women and women of foreign nationality, multivariate analysis was carried out separately in the two groups. RESULTS: In 1995, 52% of babies were breastfed at hospital discharge, including 10% of babies partially breastfed. Breastfeeding was more common among women of foreign nationality than among French women, 76 vs 49%. In both groups, breastfeeding was more common among older women, women with a high level of education or a qualified occupation; breastfeeding was also more frequent among non smokers during pregnancy and among women who attended antenatal classes. On the contrary, among French women, induction of labour and delivery in a small hospital were associated with a low level of breastfeeding; among women of foreign nationality, a low level of breastfeeding was observed for unmarried women, women who had an induction or a caesarean section, and those who delivered in a private hospital. CONCLUSION: France was at the lowest level among Western countries for which national data on breastfeeding were available. Efforts to promote breastfeeding are needed, both towards sub-groups of pregnant women and towards health professionals. Maternity hospitals should provide support to breastfeeding mothers, and avoid practices which may affect breastfeeding.     

Rapid thermal annealing applied to the optimization of titanium oxide arc

In this work, rapid thermal annealing (RTA) in the 400–700°C range is used to adjust simultaneously the index and thickness of titanium oxide layers in order to achieve an antireflection coating (ARC) in industrial conditions (large solar cells with a high throughput capability). The technique used for high production rate and low cost coating process is the atmospheric pressure chemical vapor deposition (APCVD) at low temperature.Titanium oxide layers are obtained from the hydrolysis of two precursors, namely the tetraisopropoxide titanate (TPT) and the titanium tetrachloride. In the first case, on silicon substrates at 150°C, we have obtained refractive indices of 1.8–1.9 with layer thicknesses in the range 70–100 nm. In the second case, at 100°C, the refractive index is 2.1–2.2 as deposited and the thickness in the same range. After RTA lasting 120 s at 700°C, the refractive index is 2.25 and the thickness is decreased by 40% with the first precursor, while with chloride, the index increases until 2.4 and the thickness is decreased by 30%. These results are discussed by means of X-ray diffraction and SIMS analysis.