Relative importance of informational units and their role in long-term recall by closed-head-injured patients and control groups.

Applied qualitative analysis to the information recalled by control Ss and closed-head-injured (CHI) patients. The Logical Memory subtest of the Wechsler Memory Scale (WMS) was administered to 40 CHI and 40 control Ss. Recall was tested immediately after administration, 40 min later, and 24 hrs later. The analysis took into account the importance of recalled information as determined by a prior rating according to 3 levels of importance. Results suggest that CHI patients have difficulty selectively retrieving the most important information after a long delay. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

紫外可见分光光度法在共轭亚油酸定量分析中的应用

采用UV - 91 0 0型紫外可见分光光度计 ,测定了由植物油脂制得的共轭亚油酸、共轭亚油酸甲酯、共轭亚油酸三甘酯在不同浓度时在 2 0 0nm - 30 0nm的吸光度 ,绘制出样品在不同浓度时的吸光度曲线 ,找出适宜的浓度范围 ,用MicrocalSoftwareOriginVersion 4.0做回归分析 ,由线性回归给出样品浓度和吸光度的线性关系 ,为对实验结果进行检验和校正 ,采用惠普 845 2A二极管阵列分光光度计测定了同一批样品在不同浓度范围内的吸光度 ,利用PEAutosystemXL -TurboMass测得样品中共轭亚油酸准确浓度 ,结合回归系数给出了用紫外可见分光光度计快速测定样品中共轭亚油酸含量的经验公式     

Normal Mode Solution for Frequency-Dependent Damping of a Free Particle

The normal mode transformation of the Hamiltonian equivalent of the Generalized Langevin Equation for the free particle is used to provide explicit solutions for the classical and quantum-mechanical diffusion of a free particle.     

Performance on two fixed-interval schedules in the absence of neocortex in rats.

Rats with complete surgical removal of the neocortex (neodecorticates) were trained, with milk as the reinforcer, on a 40-sec fixed-interval (FI-40) schedule, then on an FI-120, and finally reexposed to the FI-40. Like controls, neodecorticates developed and appropriately adjusted their postreinforcement pauses and response distributions and showed scallop-type responding on the FI-120 and a positive correlation between running rate and the preceding postreinforcement pause on both FI-40 schedules but not on the FI-120. On some variables neodecorticates reached asymptotic levels of performance more slowly than controls. Extended training on the first FI-40 did not differentially affect neodecorticates' performance. The results suggest that neodecorticates retain a functional timing mechanism. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

Functional Chromatography Reveals Three Natural Products that Target the Same Protein with Distinct Mechanisms of Action

Access to lead compounds with defined molecular targets continues to be a barrier to the translation of natural product resources. As a solution, we developed a system that uses discrete, recombinant proteins as the vehicles for natural product isolation. Here, we describe the use of this functional chromatographic method to identify natural products that bind to the AAA+ chaperone, p97, a promising cancer target. Application of this method to a panel of fungal and plant extracts identified rheoemodin, 1‐hydroxydehydroherbarin, and phomapyrrolidone A as distinct p97 modulators. Excitingly, each of these molecules displayed a unique mechanism of p97 modulation. This discovery provides strong support for the application of functional chromatography to the discovery of protein modulators that would likely escape traditional high‐throughput or phenotypic screening platforms.     

Design and Expected Performance of GISMO-2, a Two Color Millimeter Camera for the IRAM 30 m Telescope

We present the main design features for the GISMO-2 bolometer camera, which we build for background-limited operation at the IRAM 30 m telescope on Pico Veleta, Spain. GISMO-2 will operate simultaneously in the 1 and 2 mm atmospherical windows. The 1 mm channel uses a \(32 \times 40\) TES-based backshort under grid (BUG) bolometer array, the 2 mm channel operates with a \(16 \times 16\) BUG array. The camera utilizes almost the entire full field of view provided by the telescope. The optical design of GISMO-2 was strongly influenced by our experience with the GISMO 2 mm bolometer camera, which is successfully operating at the 30 m telescope. GISMO is accessible to the astronomical community through the regular IRAM call for proposals.     

A constraint consensus memetic algorithm for solving constrained optimization problems

Constraint handling is an important aspect of evolutionary constrained optimization. Currently, the mechanism used for constraint handling with evolutionary algorithms mainly assists the selection process, but not the actual search process. In this article, first a genetic algorithm is combined with a class of search methods, known as constraint consensus methods, that assist infeasible individuals to move towards the feasible region. This approach is also integrated with a memetic algorithm. The proposed algorithm is tested and analysed by solving two sets of standard benchmark problems, and the results are compared with other state-of-the-art algorithms. The comparisons show that the proposed algorithm outperforms other similar algorithms. The algorithm has also been applied to solve a practical economic load dispatch problem, where it also shows superior performance over other algorithms.     

Designing winning robots by careful design of their development process

We present a comprehensive robot development process and its evaluation. We designed this process in the context of a robotics course in high schools. The motivation for designing this new process was improving the robustness and reliability of robots developed by students and preparing students for becoming better designers. The newly designed process proved to be highly successful in designing top quality robots. In the process design, we explored and adapted existing design tools and methods to the specific designers, the nature of the product, the environment, the product needs, and the design context goals. At the end of this thorough design, we selected a synergetic integration of six tools and methods to compose the new comprehensive development process for this product context: conceptual design, fault-tolerant design, atomic requirements, fuzzy logic for control, creative thinking, and microprogramming-based design. The design skills of the students that learned the design process and the performance of robots they designed and participated in an international robotics contest were examined. The high school teams that studied the proposed process won the first places in an international contest. The robots developed by the students had better performance than robots built by engineers and faculty teams. Professional experts rated the robots’ designs as excellent. The students that studied the process demonstrated high level of diverse design skills including creativity and design management capabilities. Additionally, they improved their science subject grades and their attitude toward engineering. Both the results obtained by the study and the authors’ experience in teaching robotics demonstrate that the proposed robot development process could be taught successfully in high school and that it leads to superior robotic products. Our experience also indicates that this process could serve industry design by improving the robustness of robots operating in uncertain environments and supporting fast change management practices.     

Stray light correction for diode-array-based spectrometers using a monochromator

Photodiode-array-based spectrometers are increasingly being used in a wide variety of applications. However, the signal measured by this type of instrument often is not what is anticipated by the user and is often subject to contamination from stray light. This paper describes an efficient and low-cost stray light correction approach based on a relatively simple system using a monochromator-based source. The paper further discusses the limitations of using a monochromator instead of a laser, as used by previous researchers, and its impact on the quality of the stray light correction. The reliability and robustness of the stray light correction matrix generated have been studied and are also reported.