Assembly of Fully Substituted 2H-Indazoles Catalyzed by Cu2O Rhombic Dodecahedra and Evaluation of Anticancer Activity

Simultaneous C−N, and N−N bond-forming methods for one-pot transformations are highly challenging in synthetic organic chemistry. In this study, the Cu₂O rhombic dodecahedra-catalyzed synthesis of 2H-indazoles is demonstrated with good to excellent yields from readily available chemicals. This one-pot procedure involves Cu₂O nanoparticle-catalyzed consecutive C−N, and N−N bond formation followed by cyclization to yield 2H-indazoles with broad substrate scope and high functional group tolerance. Various cell-based bioassay studies demonstrated that 2H-indazoles inhibit the growth of cancer cells, typically through induction of apoptosis in a dose-dependent manner. Moreover, 2H-indazoles tested in the MDA-MB-468 cell line were capable of inhibiting cancer cell migration and invasion. Thus, it is shown that 2H-indazoles have potent in vitro anticancer activity that warrant further investigation of this compound class.     

LGVTON: a landmark guided approach for model to person virtual try-on

Multimedia Tools and Applications - In this paper, we propose a Landmark Guided Virtual Try-On (LGVTON) method for clothes, which aims to solve the problem of clothing trials on e-commerce...     

Local jet pattern: a robust descriptor for texture classification

Multimedia Tools and Applications - Methods based on locally encoded image features have recently become popular for texture classification tasks, particularly in the existence of large intra-class...     

A spiral shaped regenerative microfluidic fuel cell with Ni‐C based porous electrodes

Microchannel geometry, electrode surface area, and better fuel utilization are important aspects of the performance of a microfluidic fuel cell (MFC). In this communication, a membraneless spiral‐shaped MFC fabricated with Ni as anode and C as a cathode supported over a porous filter paper substrate is presented. Vanadium oxychloride and dilute sulfuric acid solutions are used as fuel and electrolyte, respectively, in this fuel cell system. The device generates a maximum open‐circuit voltage of ~1.2 V, while the maximum energy density and current density generated from the fuel cell are ~10 mW cm^?2 and ~51 mA cm^?2, respectively. The cumulative energy density generated from the device after five cycles are measured as ~200 mW after regeneration of the fuel by applying external voltage. The spiral design of the fuel cell enables improved fuel utilization, rapid diffusive transport of ions, and in‐situ regeneration of the fuel. The present self‐standing spiral‐shaped MFC will eliminate the challenges associated with two inlet membrane‐less fuel cells and has the potential to scale up for commercial application in portable energy generation.     

Robust vectorization method for electrical circuit drawings using component morphology

Pattern Analysis and Applications - Decomposition and representation of electrical circuit drawings to a suitable vector form has widespread applications related to data compression, storage,...     

Monitoring the curing of furan resins through the exothermic heat of reaction

The curing reaction of furan resins was monitored through the exothermic heat of reaction by means of a simple technique. p-Toluene sulphonic acid dissolved in acetone was used to catalyse the curing reaction. A ‘cure rate index’, defined as the maximum temperature rise per unit time per unit mass of the resin, was used as a measure of the rate of cure. The index value increases exponentially with the catalyst concentration. Interestingly, for the same catalyst concentration the index value also increases significantly with the period of ageing of the catalyst solution. A method is developed for deriving the activation energy for the curing reaction from the exothermic heat data for non-isothermal cure. The activation energy is found to increase with resin viscosity and to decrease exponentially with increasing catalyst concentration. Quantitative expressions are derived relating activation energy with catalyst concentration.     

Oxidation of Aqueous Sulphur Dioxide Catalysed by Poly-4-vinylpyridine–Cu(II) Complex. Part 2: Combined Homogeneous and Heterogeneous Phase Oxidation

Aqueous phase oxidation of sulphur dioxide at low concentrations catalysed by a PVP–Cu complex in the solid phase and dissolved Cu(II) in the liquid phase is studied in a rotating catalyst basket reactor (RCBR). The equilibrium adsorption of Cu(II) and S(VI) on PVP particles is found to be of the Langmuir-type. The diffusional effects of S(IV) species in PVP–Cu resin are found to be insignificant whereas that of product S(VI) are found to be significant. The intraparticle diffusivity of S(VI) is obtained from independent tracer experiments. In the oxidation reaction HSO₃⁻ is the reactive species. Both the S(IV) species in the solution, namely SO₂(aq) and HSO₃⁻, get adsorbed onto the active PVP–Cu sites of the catalyst, but only HSO₃⁻ undergoes oxidation. A kinetic mechanism is proposed based on this feature which shows that SO₂(aq) has a deactivating effect on the catalyst. A rate model is developed for the three-phase reaction system incorporating these factors along with the effect of concentration of H₂SO₄ on the solubility of SO₂ in the dilute aqueous solutions of Cu(II). Transient oxidation experiments are conducted at different conditions of concentration of SO₂ and O₂ in the gas phase and catalyst concentration, and the rate parameters are estimated from the data. The observed and calculated profiles are in very good agreement. This confirms the deactivating effect of non-reactive SO₂(aq) on the heterogeneous catalysis. © 1997 SCI.     

Electrochemical synthesis of Li-doped NiFeCo oxides for efficient catalysis of the oxygen evolution reaction in an alkaline environment

Oxygen evolution reaction (OER) is an essential reaction for overall electrochemical water splitting. In this present study, we adopt a facile electrochemical deposition method to synthesize the Li-doped NiFeCo oxides for OER in an alkaline medium. The scanning electron microscopy, X-ray diffraction, Brunauer-Emmet-Teller method and X-ray photo-electron spectroscopy provides the information of morphology, structure, specific surface area and electronic state of the electrocatalysts respectively. Investigates the electrochemical properties by the thin-film technique on a rotating disk electrode and in a single-cell laboratory water electrolyzer connects with electrochemical impedance spectroscopy. Among the catalysts under investigation, Ni_0·9Fe_0·1Co_1·975Li_0·025O₄ exhibits the highest activity towards oxygen evolution reaction, and explains the activity by the oxygen binding energy; such knowledge can be helped to develop better catalyst. We achieve onset over potential 220 mV and receive 10 mA cm^?2 current density at over potential 301 mV with Tafel slope 62 mV dec^?1 in 1 M KOH solution. The results are similar to recently published catalysts in the literature. In water electrolyzer, the Ni_0·9Fe_0·1Co_1·975Li_0·025O₄ modified nickel foam anode exhibits a current density of 143 mA cm^?2 at a cell voltage of 1.85 V in 10 wt% KOH and a temperature of 50 °C.     

Evaluation of Ni-Cr-P coatings electrodeposited on low carbon steel bipolar plates for polymer electrolyte membrane fuel cell

Polymer electrolyte membrane fuel cell (PEMFC) stacks suffer from the high cost and low volumetric energy of non-porous graphite bipolar plates. To resolve this problem, a bilayer coating consisting of Ni and Ni–Cr–P is deposited on AISI 1020 low-carbon steel using pulse electrodeposition. Ni/Ni–Cr–P-coated AISI 1020 is evaluated as a bipolar plate material for PEMFCs. Ni/Ni–Cr–P-coated substrates exhibit better corrosion resistance in both cathodic (air-purging) and anodic (H₂-purging) environment than the bare AISI 1020 substrate and lower interfacial contact resistance (ICR) than bare AISI 1020 and stainless steel. Further, it is expected to show better water management as the Ni/Ni–Cr–P coating is more hydrophobic than the bare substrate. Preliminary studies show that Ni/Ni–Cr–P-coated AISI 1020 plate can be a suitable candidate for replacing graphite as the bipolar plate of PEMFCs.