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991.
Dr. Eric M. Lewandowski Dr. Łukasz Szczupak Dr. Aleksandra Kowalczyk Dr. Gracia Mendoza Prof. Manuel Arruebo Lian M. C. Jacobs Prof. Paweł Stączek Prof. Yu Chen Prof. Konrad Kowalski 《Chembiochem : a European journal of chemical biology》2020,21(15):2187-2195
The conjugation of organometallic groups to current β-lactam antibiotics is a field of increasing study due to the ability of certain organometallic groups to enhance the antibiotic potency of these drugs. Herein, we report the antibacterial properties of two metallocenyl (ferrocenyl and ruthenocenyl) 7-aminocephalosporanic acid (7-ACA) antibiotic conjugates. Continuing a trend we found in our previous studies, the ruthenocenyl conjugate showed greater antibacterial activity than its ferrocenyl counterpart. Compared with the previously published 7-aminodesacetoxycephalosporanic acid (7-ADCA) conjugates, the 3-acetyloxymethyl group significantly improved the compounds’ activity. Furthermore, the Rc-7-ACA compound was more active against clinical Staphylococcus aureus isolates than the ampicillin reference. Noticeably, neither of the two new compounds showed an undesirable toxic effect in HeLa and L929 cells at the concentrations at which they displayed strong antibacterial effects. The antibacterial activity of the two metallocenyl 7-ACA derivatives was further confirmed by scanning electron microscopy (SEM). SEM micrographs showed that bacteria treated with metallocenyl 7-ACA derivatives feature cell wall damage and morphology changes. Using a CTX-M-14 β-lactamase competition assay based on nitrocefin hydrolysis, we showed that the Rc-7-ACA bound more favorably to CTX-M-14 than its ferrocenyl counterpart, again confirming the superiority of the ruthenocenyl moiety over the ferrocenyl one in interacting with proteins. We also report a 1.47 Å resolution crystal structure of Rc-7-ACA in complex with the CTX-M-14 E166A mutant, an enzyme sharing a similar active site configuration with penicillin-binding proteins, the molecular target of β-lactam antibiotics. These results strengthen the case for the antibacterial utility of the Rc and Fc groups. 相似文献
993.
Xiangyang Lian Wanjun Liu Jianqiang Xie Qiang Shi Shaowei Yao Yuexin Guo Yufeng Zhang 《应用聚合物科学杂志》2020,137(47):49557
Thin film composite (TFC) reverse osmosis (RO) membranes with high permeability have been prepared by interfacial polymerization based on tailoring the polysulfone (PSf) substrate structure by in situ embedded poly(p-phenylene terephthamide) (PPTA) star-like rigid supports. The star-like rigid supports were observed by the polarizing optical microscopy (POM) and transmission electron microscope (TEM). The surface properties of the substrates were investigated by FTIR, the water contact angle (WCA), FESEM and AFM. The WCA was decreased from 88.5° to 72.3° with the PPTA increasing from 0% to 8%, and the surface roughness increased from 24.2, 25.1, 33.5 and 58.6 nm, respectively. Furthermore, numerous interconnect micro-structures were constructed in the substrate when the PPTA content was up to 8%. The pure water flux of 8% PPTA/92%PSf substrate was up to 377.0 L m−2 h−1 and the flux decline rate was lowest (64%) after compacted at 5.5 MPa for 30 min. Otherwise, increasing the PPTA contents in the substrate enhanced the roughness, encouraged nanosheet formation and improved the permeability of TFC RO membranes. The pure water flux of the TFC RO membranes increased from 36.32 to 58.42 L m−2 h−1, where the NaCl rejection was about 99.5% at 5.5 MPa. 相似文献
994.
Wenhao Qiu Guangyao Lian Peng Zhou Kaoli Huang 《Quality and Reliability Engineering International》2020,36(5):1592-1603
An extended failure mode effect and criticality analysis (FMECA)-based sample allocation method for testability verification is presented in this study to deal with the poor representativeness of test sample sets and the randomness of the testability evaluation results caused by unreasonable selection of failure samples. First, the fault propagation intensity is introduced as part of the extended information of FMECA, and the sample allocation impact factors of component units and failure modes are determined under this framework. Then, the failure mode similarity and impact factor support are defined, and the game decision method for weighing the relationship between similarity and support is proposed to obtain the weight of failure mode impact factor. Finally, a two-step allocation framework of test samples is formulated to realize the sample allocation of component units and failure modes. This method is applied to the testability verification test of a launch control system. Results show that this method can obtain more representative test samples compared with the traditional sample allocation method while effectively reducing randomness of single testability evaluation result. 相似文献
995.
从钢铁生产过程中水资源使用时的能耗角度研究了钢铁联合企业的水能关系,提出了水能强度的概念来评价企业生产过程中水资源利用的节能水平,建立了钢铁企业的水能关系模型。以中国某大型钢铁联合企业为例,计算并分析了该企业的水能关系。该企业总的水能量为55 709 kW·h/h,重复用水水能量占整个钢铁企业全部水能量的82%,补水水能量占16%,排水水能量占1%;各工序中热轧工序占比最大,其次是炼铁、炼钢工序,冷轧、烧结和炼焦工序较低。该企业的吨钢水能强度为0.208 kW·h/m3,炼铁工序的水能强度最高,热轧、炼钢工序次之,烧结、冷轧和炼焦工序较低。最后,从钢铁生产过程水资源利用的角度得到节能的方向及措施。 相似文献
996.
Zhou Wei Lian Cheng Zeng Zhigang Xu Bingrong Su Yixin 《Neural Processing Letters》2021,53(5):3427-3443
Neural Processing Letters - Because it is very expensive to collect a large number of labeled samples to train deep neural networks in certain fields, semi-supervised learning (SSL) researcher has... 相似文献
997.
Zhihong Lian Jing Wang Yuhua Lv Shubin Wang Qiang Su 《Journal of Alloys and Compounds》2007,430(1-2):257-261
A valence change from Eu3+ to Eu2+ was observed in the europium ion-doped ZnO–B2O3–P2O5 glasses prepared at high temperature in air. The fluorescence emission spectrum of the sample consists of a broad emission band ascribed to the 5d–4f transition of Eu2+ ion and sharp emission peaks assigned to the transitions of 5Do–7FJ (J = 0, 1, 2, 3, and 4) of Eu3+ ion, indicating that part of Eu3+ can be reduced into Eu2+ in the glass. A charge compensation model is proposed. The rigid tetrahedral network structure of glasses plays an important role in stability of Eu2+. The fabrication conditions are also studied. 相似文献
998.
999.
1000.
研究非线性互联系统的分散镇定问题。利用向量 L yapunov函数 ,对一类具有互联结构的非线性大系统给出了 L yapunov型的分散镇定条件 ,并给出了分散镇定的反馈控制律 相似文献