RAID5 performance with distributed sparing

Distributed sparing is a method to improve the performance of RAID5 disk arrays with respect to a dedicated sparing system with N+2 disks (including the spare disk), since it utilizes the bandwidth of all N+2 disks. We analyze the performance of RAID5 with distributed sparing in normal mode, degraded mode, and rebuild mode in an OLTP environment, which implies small reads and writes. The analysis in normal mode uses an M/G/1 queuing model, which takes into account the components of disk service time. In degraded mode, a low-cost approximate method is developed to estimate the mean response time of fork-join requests resulting from accesses to recreate lost data on the failed disk. Rebuild mode performance is analyzed by considering an M/G/1 vacationing server model with multiple vacations of different types to take into account differences in processing requirements for reading the first and subsequent tracks. An iterative solution method is used to estimate the mean response time of disk requests, as well as the time to read each disk, which is shown to be quite accurate through validation against simulation results. We next compare RAID5 performance in a system (1) without a cache; (2) with a cache; and (3) with a nonvolatile storage (NVS) cache. The last configuration, in addition to improved read response time due to cache hits, provides a fast-write capability, such that dirty blocks can be destaged asynchronously and at a lower priority than read requests, resulting in an improvement in read response time. The small write penalty is also reduced due to the possibility of repeated writes to dirty blocks in the cache and by taking advantage of disk geometry to efficiently destage multiple blocks at a time     

Sampled- and continuous-time passivity and stability of virtual environments

We propose a new time-domain passivity observer (PO) and passivity controller (PC) which removes the constant-velocity assumption during one sample time, which was used in our previous PO/PC approach. A new sampled-time definition of passivity is introduced, and this new definition is compared with the previous sampled-time definition of passivity. Through this comparison, we propose the more accurate PO/PC approach. The proposed new PO/PC approach is applied to the "Excalibur" haptic interface system with very high stiffness (K = 120 kN/spl middot/m) virtual environment, and stable contact is demonstrated.     

Resource policing to support fine-grain cycle stealing in networks of workstations

We present the design, implementation, and performance evaluation of a suite of resource policing mechanisms that allow guest processes to efficiently and unobtrusively exploit otherwise idle workstation resources. Unlike traditional policies that harvest cycles only from unused machines, we employ fine-grained cycle stealing to exploit resources even from machines that have active users. We developed a suite of kernel extensions that enable these policies to operate without significantly impacting host processes: 1) a new starvation-level CPU priority for guest jobs, 2) a new page replacement policy that imposes hard bounds on physical memory usage by guest processes, and 3) a new I/O scheduling mechanism called rate windows that throttle guest processes' usage of I/O and network bandwidth. We evaluate both the individual impacts of each mechanism, and their utility for our fine-grain cycle stealing.     

真核细胞蛋白质翻译起始研究进展

在大量有关机制的研究基础上,针对真核蛋白质翻译起始,提出了核糖体沿mRNA滑动识别翻译起始位点的机制和核糖体从mRNA内部识别翻译起始位点的机制.     

Factors Affecting Flow-Mediated Vasodilatation in Hemodialysis Patients

Clinical manifestation of overt vascular disease may be preceded for years by endothelial dysfunction. Objective: This study was undertaken to evaluate endothelial function in ESRD patients and correlation between endothelial function and clinical and biochemical parameters. Methods: 32 stable ESRD patients (male : female = 16 : 16, average age: 55.2 ± 13.0) on hemodialysis were included. A 10‐MHz ultrasound transducer was used to image the brachial artery. Brachial artery diameter was measured, and reactive hyperemia was induced by inflation to 250 mmHg for 5 min and then deflation of a pneumatic cuff. After release of the cuff, brachial artery diameter was measured. Results: In the entire study population and non‐diabetic group, the %FMD (% flow‐mediated dilatation, % change of brachial artery diameter between before and after cuff inflation) did not show any significant correlation with duration of dialysis, age, hypertension, albumin, CRP, total cholesterol, LDL and HDL cholesterol, and triglyceride. However, the %FMD of diabetic patients was lower than that of non‐diabetics. Among the patients with diabetes, the group of patients with FMD of <5.2% showed significant lower serum albumin and significantly higher ln(CRP) levels compared to the group of patients with FMD ≥5.2%. The %FMD showed significant positive correlation with serum albumin level and significant negative correlation with ln(CRP) in diabetic patients. Conclusion: These findings suggest that endothelial dysfunction, estimated by FMD, was significantly more prominent in diabetic ESRD, especially with low serum albumin and high CRP levels.     

Immobilization of laccase on carbon nanomaterials

Laccase from Trametes versicolor was readily immobilized on carbon nanomaterials including multiwalled carbon nanotubes (MWNTs), carboxylated multiwalled carbon nanotubes (MWNT-COOHs), and graphene oxides (GOs), by physical adsorption without using coupling agents. The immobilized amount of laccase strongly depends on the pH of the aqueous buffers of the immobilization mixture. As the pH of the aqueous buffer for immobilization increases, the immobilized amount of laccase decreases. The activity of the immobilized laccase on the three carbon nanomaterials exhibits a bell-shaped dependence on the pH of the immobilization solution with maximum activity at pH 6 or 7. When the immobilization solution becomes acidic or basic, the activity of the immobilized laccase declines significantly. The amount and the activity of immobilized laccase were maximum for graphene oxides as substrate material for immobilization.     

Field Evaluation of the Bacterial Volatile Derivative 3-Pentanol in Priming for Induced Resistance in Pepper

Plants are defended from attack by emission of volatile organic compounds (VOCs) that can act directly against pathogens and herbivores or indirectly by recruiting natural enemies of herbivores. However, microbial VOC have been less investigated as potential triggers of plant systemic defense responses against pathogens in the field. Bacillus amyloliquefaciens strain IN937a, a plant growth-promoting rhizobacterium that colonizes plant tissues, stimulates induced systemic resistance (ISR) via its emission of VOCs. We investigated the ISR capacity of VOCs and derivatives collected from strain IN937a against bacterial spot disease caused by Xanthomonas axonopodis pv. vesicatoria in pepper. Of 15 bacterial VOCs and their derivatives, 3-pentanol, which is a C8 amyl alcohol reported to be a component of sex pheromones in insects, was selected for further investigation. Pathogens were infiltrated into pepper leaves 10, 20, 30, and 40 days after treatment and transplantation to the field. Disease severity was assessed 7 days after transplantation. Treatment with 3-pentanol significantly reduced disease severity caused by X. axonopodis and naturally occurring Cucumber mosaic virus in field trials over 2 years. We used quantitative real-time polymerase chain analysis to examine Pathogenesis-Related genes associated with salicylic acid (SA), jasmonic acid (JA), and ethylene defense signaling. The expression of Capsicum annuum Pathogenesis-Related protein 1 (CaPR1), CaPR2, and Ca protease inhibitor2 (CaPIN2) increased in field-grown pepper plants treated with 3-pentanol. Taken together, our results show that 3-pentanol triggers induced resistance by priming SA and JA signaling in pepper under field conditions.     

Grafting maleic anhydride onto EVA and effect on the physical and rheological properties of PETG/EVA-g-MAH blends

Maleic anhydride (MAH) was grafted onto ethylene vinyl acetate copolymer (EVA) in the internal mixer in the presence of dicumyl peroxide (DCP), and a prepared reactive compatibilizer, MAH-g-EVA, was blended with Poly (ethylene glycol-co-cyclohexane-1,4-dimethanol terephthalate) (PETG). The gel content determination and element analysis (EA) was performed to confirm the grafting reaction. It was found that grafting reaction of MAH on to EVA could compete with crosslinking reaction of DCP during the modification process. In addition, the introduction of small amount of MAH showed a great effect on reducing gel content by decreasing crosslink reaction. As MAH content increased, grafted MAH concentration increased, whereas the grafting yield decreased. It was also confirmed that MAH-g-EVA acted as a reactive compatibilizer in the blend with PETG, and enhanced compatibility by reacting with the hydroxyl end groups, OH, of PETG. Addition of EVA in the blend leads a plastic deformation of PETG, and MAH had a great effect on enhancing interfacial adhesion resulting in significant increasing of % strain; however, improved compatibility could not be changed much in low strain tensile strength and Young's modulus. © 2012 Wiley Periodicals, Inc. J Appl Polym Sci, 2012