Study on correlation of mammographic features、pathology and molecular bology of breast infiltrating ductal carcinoma

Objective To investigate the correlation among mammographic features、pathology and molecu-lar biology markers of breast infitrating ductal carcinoma(IDC) tissues.Methods The mammographic features of 93 cases with IDC confirmed by surgery and histopathology were analyzed retrospectively.The mastectomy specimens of the IDC were stained with immunohistochemistry,and the expression of ER、PR、C-erbB-2 were measured.The rela-tionship between the immunohistochemical pathologic results and mammographic features was analyzed.Results A-mong the 93 cases of IDC,ER positive expression was positively correlated with the spiculate margin of breast cancer (P<0.05);C-erbB-2 positive expression was positively correlated(P<0.05).Moreover,ER and PR positive expres-sion showed a significant inverse correlation with the calcifying of breast cancer(P>0.05);ER and PR positive ex-pression was positively correlated with the transfer of lymph(P<0.05);there existed correlation between the positive expression of C-erbB-2 and lymphatic metastasis and pathohistology grade(P<0.05).Conclusion There was a pos-itive correlation among IDC mammography、pathology and the abnormal value of ER、PR and C-erbB-2.The X-ray mammography could reflect the diagnosis value of ER、PR and C-erbB-2 roughly,and thadpractical value in determi-ning prognoses and endocrinotherapy.     

MRI检查在膝关节交叉韧带损伤中的应用

目的：观察MRI检查在膝关节交叉韧带损伤诊断中的应用情况.方法：收集2009年1月至2011年3月广东省揭阳市人民医院收治的74例膝关节交叉韧带损伤患者的临床资料,以关节镜检查的诊断结果作为金标准,分析比较MRI检查的准确率.结果：本组74例膝关节交叉韧带损伤患者中,关节镜诊断阳性率、临床体检阳性率、MRI检查初次诊断阳性率分别为100％（ 74/74）、99％（ 73/74）、86％（64/74）,MRI检查与前两者比较,差异具有统计学意义（P＜0.05）.MRI检查的诊断假阳性率为14％（10/74）.患者MRI影像表现较为复杂,如韧带连续性中断、信号增高、外形不规则、韧带水平走向等,尤其是急性损伤的高信号及积液的高信号常常影响MRI检查结果.结论：MRI检查对于膝关节前后交叉韧带损伤的诊断和手术方案的准备都治必不可少,但需结合临床的分析,可疑患者必要时应进行膝关节镜检查,以免造成漏诊.     

甲醇和汽油汽车尾气对兔肺巨噬细胞免疫功能影响的比较研究

目的：比较汽油和四醇汽车尾气提取物对兔肺巨噬细胞免疫功能的影响，为甲醇燃料的推广应用提供依据。方法：取激活的兔肺巨噬细胞体外培养，分别进行玫瑰花环实验、抗体介导的细胞毒作用实验和抗肿瘤细胞毒作用实验。结果：汽油和甲醇尾气提取物可使巨噬细胞玫瑰花环形成率、肺巨噬细胞抗肿瘤细胞毒作用受到抑制，但与汽油尾气提取物比较，甲醇的抑制作用较弱，汽油尾气提取物对抗体介导的细胞毒作用有显著的抑制作用，但未见甲醇尾气提取物有此作用。结论：甲醇汽车尾气提取物对巨噬细胞免疫活性的抑制作用显著低于汽油尾气提取物。