肺栓塞临床分析

目的提高对肺栓塞的认识和诊治水平。方法对23例肺栓塞患者的超声检查、X线影像学检查、肺通气／血流灌注检查等资料进行回顾性分析。结果23例肺栓塞患者都有下肢深静脉炎或血栓形成、术后、创伤或不适当的长期卧床、慢性心肺疾病、糖尿病和肿瘤等基础疾病。由于及时诊断和及时的抗凝治疗,17例（73．9％）患者治疗后存活。23例肺栓塞患者采用放射性核素肺通气／灌注扫描,阳性率为95％。结论肺栓塞仍是一个被人们认识不足的疾病,因此应予重视,并要求我们对临床高度怀疑者应尽快进行肺栓塞的诊断程序。放射性核素肺通气／关注扫描是一项安全、简便、无创、有价值的肺栓塞的筛选和诊断方法。     

匹罗卡品致(癎)大鼠海马中表达生长抑素的中间神经元数目变化及其轴突出芽

Objective To investigate the roles of somatostatin(SS)positive intemeurons in the development and compensation of temporal lobe epilepsy.Methods Piloearpine-induced epilepsy rat model was established.Immunohistochemistry method was used to detect number changes and axonal sprouting of SS positive intemeurons in different domains of the hippocampus at difierent time points.Degeneration of SS positive interneurons and their neurophils were detected by the double immunofluorescence staining with SS and Fluoro-Jade B(FJB)at 7 and 60 days after status epilepticus (SE).Results In the exoerimental rat group,the number of SS positive neurons decreased in each hippocampal domain,and it reached the lowest at 7 days post-SE(There were 11.1±3.3 in hilus,2.8±0.9 in CA1region and 1.8±0.7 in CA1region,t=13.519,9.644 and 8.808,all P<0.01).In chronic phase,the number of SS neurons gradually recovered,and exceeded the control group in CA1 area at 60 days post-SE(12.8±1.5 vs 8.8±1.3,t=-4.506,P<0.01),however,the number of SS neurons in the hilus(25.5±4.6)and CA1 area(4.8±0.8)remained significantly less than normal levels(t value were 4.691 and 3.953.both P<0.01).Increased SS positive fibers were found in the lacunosum-molecular (1m)layer and outer molecular layer of dentate gyrus after 30 days post-SE,and numerous SS positive fibers were seen threnghout the layers of area CA1 at 60 days post-SE.Double immunofluuorescence revealed that a few SS positive interneurons and fibers were also labeled by FJB in area CA1 at 7 days post-SE and in CA domain/hilus at 60 days post-SE.Conclusions SS intemeurons loss plays an important role in the development of temporal lobe epilepsy.The loss is partially caIlsed by the degeneration and death of neurons;SS positive neurophils increase within area CA1 in chronic phase may play a significant role in the generation and compensation of temporal lobe epilepsy.     

海口地区围绝经期妇女状况的调查

目的 通过流行病学调查了解海口地区围绝经期妇女绝经期状况，为开展围绝经期及绝经后妇女的保健工作提供依据。方法 随机选取海南热带地区40～65岁围绝经期妇女，通过问卷调查形式了解其绝经年龄、围绝经期症状及其相关影响因素。结果 该地区妇女多产及口服避孕药可以使绝经年龄后延，潮热与出汗等绝经相关症状相对不明显，运动及饮食均影响绝经症状，对绝经相关知识认知程度低，接受激素替代疗法的占极少数。结论 今后在海南热带地区应因地制宜地大力宣传提倡绝经相关的知识。     

肺栓塞23例临床分析

肺栓塞是内源性或外源性栓子阻塞肺动脉及其分支引起的肺循环障碍的临床和病理生理综合征。据流行病学资料显示 ,急性肺栓塞病人约 11%死于发病后 1h内 ,89%活到 1h以上 ,多数病人仍有机会进行检查和治疗 ,而得以治疗的病人中 92 %可生存 ,这说明早期诊断、及时治疗的重要性[1] 。本文对 2 3例肺栓塞进行回顾性分析。1　临床资料1 1　一般资料　 2 3例根据临床表现结合超声检查、X线及放射性核素显像确诊。男 16例 ,女 7例 ;年龄 2 5～ 92岁。基础疾病 :下肢深静脉炎 9例 ,外科术后及下肢创伤 3例 ,慢性心肺疾病 5例 ,恶性肿瘤 2例 ,糖尿病…     

剖宫产率及剖宫产指征动态变化及增长速度分析

剖宫产术使用恰当是抢救或避免母婴危险的最有效手段，但无节制地扩大使用，则无助于降低孕产妇及围生儿的死亡率。合理使用剖宫产术，是产科工作者的责任与义务。现对1993年1月～2007年12月我院剖宫产的相关问题做一回顾分析，旨在探讨剖宫产指征的变化及剖宫产率上升原因，以正确掌握剖宫产指征，提高产科质量。     

匹罗卡品致(癎)大鼠海马中表达生长抑素的中间神经元数目变化及其轴突出芽

Objective To investigate the roles of somatostatin(SS)positive intemeurons in the development and compensation of temporal lobe epilepsy.Methods Piloearpine-induced epilepsy rat model was established.Immunohistochemistry method was used to detect number changes and axonal sprouting of SS positive intemeurons in different domains of the hippocampus at difierent time points.Degeneration of SS positive interneurons and their neurophils were detected by the double immunofluorescence staining with SS and Fluoro-Jade B(FJB)at 7 and 60 days after status epilepticus (SE).Results In the exoerimental rat group,the number of SS positive neurons decreased in each hippocampal domain,and it reached the lowest at 7 days post-SE(There were 11.1±3.3 in hilus,2.8±0.9 in CA1region and 1.8±0.7 in CA1region,t=13.519,9.644 and 8.808,all P<0.01).In chronic phase,the number of SS neurons gradually recovered,and exceeded the control group in CA1 area at 60 days post-SE(12.8±1.5 vs 8.8±1.3,t=-4.506,P<0.01),however,the number of SS neurons in the hilus(25.5±4.6)and CA1 area(4.8±0.8)remained significantly less than normal levels(t value were 4.691 and 3.953.both P<0.01).Increased SS positive fibers were found in the lacunosum-molecular (1m)layer and outer molecular layer of dentate gyrus after 30 days post-SE,and numerous SS positive fibers were seen threnghout the layers of area CA1 at 60 days post-SE.Double immunofluuorescence revealed that a few SS positive interneurons and fibers were also labeled by FJB in area CA1 at 7 days post-SE and in CA domain/hilus at 60 days post-SE.Conclusions SS intemeurons loss plays an important role in the development of temporal lobe epilepsy.The loss is partially caIlsed by the degeneration and death of neurons;SS positive neurophils increase within area CA1 in chronic phase may play a significant role in the generation and compensation of temporal lobe epilepsy.     

沙眼衣原体感染输卵管性不孕妇女性激素和氧化应激水平分析

目的分析沙眼衣原体阳性输卵管堵塞妇女血清性激素雌激素(E2)、人促黄体生成素(LH)、促卵泡生成激素(FSH)水平和宫颈分泌物氧化应激标志物丙二醛(MDA)和过氧化氢(H2O2)含量,了解沙眼衣原体阳性输卵管堵塞妇女性激素和氧化应激水平,为临床治疗衣原体阳性输卵管堵塞提供参考。方法收集2015年2月-2016年8月就诊于医院生殖健康门诊并同意参与研究的20~38岁的妇女为研究对象,按照输卵管是否阻塞和沙眼衣原体是否阳性进行分组,其中输卵管性可育且沙眼衣原体阴性者为对照组(42例)、输卵管堵塞且沙眼衣原体阴性者为阴性组(56例)、输卵管堵塞且沙眼衣原体阳性者为阳性组(61例);分析所有妇女性激素水平及宫颈分泌物氧化应激标志物含量。结果三组妇女性激素E2、LH、FSH水平比较差异均无统计学意义;宫颈分泌物氧化应激标志物MDA与H2O2水平比较差异有统计学意义(P0.05),阳性组妇女的氧化应激标志物MDA含量高于阴性组(t=12.785,P0.001),H_2O_2含量高于阴性组(t=11.206,P0.001);阳性组妇女大部分无明显症状,少部分出现轻微下腹部疼痛、点滴阴道出血和排尿困难等症状。结论沙眼衣原体感染和输卵管堵塞不会影响妇女体内性激素水平,但体内存在氧化应激,损害妇女生育能力。     

全程人性化服务对孕期及产后抑郁的影响

目的:探讨全程人性化服务对孕期抑郁症状及产后抑郁症状产生的影响。方法:选择在产科门诊登记进行产前检查的孕妇600例,采用随机、单盲的前瞻性队列研究,600例孕妇按简单随机法分为实验组和对照组,实验组实施全程人性化护理服务模式,对照组实施传统的护理服务模式。所有孕妇入组时由专人进行宗氏抑郁自评量表(SDS)、一般因素及一般情况的评估,每月随访产后抑郁相关危险因素,所有产妇产后7天和42天由专人采用爱丁堡产后抑郁调查表(EPDS)进行产后抑郁的单盲筛查评估。结果:对照组孕期入选时和临产前抑郁症状的检出率分别为5.7%和7.9%,实验组分别为5.3%和2.8%,两组间差异均有统计学意义(P值均<0.05),临产前差异更明显;产后7天和42天抑郁症发生率实验组明显低于对照组(5.94%比9.12%,4.06%比16.35%),且实验组随时间延长而发生率下降,对照组则明显上升。结论:全程人性化服务能在一定程度上缓解孕期抑郁症状,降低产后抑郁的发生率。     

盐酸克林霉素注射液部分安全性试验

目的 评价盐酸克林霉素注射液注射给药的安全性.方法 采用家兔耳缘静脉血管刺激性试验、肌肉刺激性试验、体外溶血性试验、豚鼠全身主动过敏试验和大鼠被动皮肤过敏试验等方法进行研究.结果 盐酸克林霉素注射液静脉滴注对给药部位血管无明显刺激作用,肌内注射给药对注射部位有一定的刺激性;豚鼠全身主动过敏反应和大鼠被动皮肤过敏反应为阴性;对家兔红细胞无溶血和凝集作用.结论 试验所用的盐酸克林霉素注射液临床静脉滴注给药安全性较好,肌内注射给药对注射部位具有刺激性.     

匹罗卡品致(癎)大鼠海马中表达生长抑素的中间神经元数目变化及其轴突出芽

Objective To investigate the roles of somatostatin(SS)positive intemeurons in the development and compensation of temporal lobe epilepsy.Methods Piloearpine-induced epilepsy rat model was established.Immunohistochemistry method was used to detect number changes and axonal sprouting of SS positive intemeurons in different domains of the hippocampus at difierent time points.Degeneration of SS positive interneurons and their neurophils were detected by the double immunofluorescence staining with SS and Fluoro-Jade B(FJB)at 7 and 60 days after status epilepticus (SE).Results In the exoerimental rat group,the number of SS positive neurons decreased in each hippocampal domain,and it reached the lowest at 7 days post-SE(There were 11.1±3.3 in hilus,2.8±0.9 in CA1region and 1.8±0.7 in CA1region,t=13.519,9.644 and 8.808,all P<0.01).In chronic phase,the number of SS neurons gradually recovered,and exceeded the control group in CA1 area at 60 days post-SE(12.8±1.5 vs 8.8±1.3,t=-4.506,P<0.01),however,the number of SS neurons in the hilus(25.5±4.6)and CA1 area(4.8±0.8)remained significantly less than normal levels(t value were 4.691 and 3.953.both P<0.01).Increased SS positive fibers were found in the lacunosum-molecular (1m)layer and outer molecular layer of dentate gyrus after 30 days post-SE,and numerous SS positive fibers were seen threnghout the layers of area CA1 at 60 days post-SE.Double immunofluuorescence revealed that a few SS positive interneurons and fibers were also labeled by FJB in area CA1 at 7 days post-SE and in CA domain/hilus at 60 days post-SE.Conclusions SS intemeurons loss plays an important role in the development of temporal lobe epilepsy.The loss is partially caIlsed by the degeneration and death of neurons;SS positive neurophils increase within area CA1 in chronic phase may play a significant role in the generation and compensation of temporal lobe epilepsy.