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41.
Dr. Lina Liang Tong-You Wade Wei Pei-Yu Wu Wouter Herrebout Ming-Daw Tsai Prof. Stéphane P. Vincent 《Chembiochem : a European journal of chemical biology》2020,21(20):2982-2990
d -Glycero-d -manno-heptose-1β,7-bisphosphate (HBP) and d -glycero-d -manno-heptose-1β-phosphate (H1P) are bacterial metabolites that were recently shown to stimulate inflammatory responses in host cells through the activation of the TIFA-dependent NF-κB pathway. To better understand structure-based activity in relation to this process, a family of nonhydrolyzable phosphonate analogues of HBP and H1P was synthesized. The inflammation modulation by which these molecules induce the TIFA-NF-κB signal axis was evaluated in vivo at a low-nanomolar concentration (6 nM) and compared to that of the natural metabolites. Our data showed that three phosphonate analogues had similar stimulatory activity to HBP, whereas two phosphonates antagonized HBP-induced TIFA-NF-κB signaling. These results open new horizons for the design of pro-inflammatory and innate immune modulators that could be used as vaccine adjuvant. 相似文献
42.
Weigang Liang Beibei Wang Guofeng Shen Suzhen Cao Bertrand Mcswain Ning Qin Liyun Zhao Dongmei Yu Jicheng Gong Shanshan Zhao Yawei Zhang Xiaoli Duan 《Indoor air》2020,30(2):264-274
Stunting adversely affects physical and mental outcomes of children. It has not been examined whether household air pollution from solid fuel combustion is a risk factor for stunting in children. In a total of 41,439 children aged 6-17 across China, height was measured using a unified protocol. Multivariable linear regression models and logistic regression models were used to assess the associations of solid fuel use for cooking/heating with stunting in children. Adjusted for covariates, cooking/heating with solid fuel was significantly associated with a lower z-score for height for age and sex (β = −0.21 [−0.32 to −0.09] and −0.17 [−0.31 to −0.03], respectively) and an increased risk of stunting with an estimated ORs of 1.34 [1.07~1.68] and 1.37 [1.02~1.83], respectively. The risk of stunting associated with solid fuel use was statistically significant in high-age children. And the effect was greater on girls than on boys, though the difference was not statistically significant. Our study suggested that Chinese children living in households using solid fuel had a significantly higher risk of stunting than those living in households using cleaner fuel. 相似文献
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Yan Xiong Xianwu Du Mingyu Xiang Hao Wang Weimin Wang Zhengyi Fu 《Journal of the European Ceramic Society》2018,38(12):4167-4172
The densification behaviors of pure B4C and B4C-ZrO2 mixtures were compared during hot pressing. The results showed that in-situ formed ZrB2 effectively enhanced the densification process of B4C-ZrO2 mixtures, more significantly during the intermediate stage. Within the relative density ranging from 0.75 to 0.90, the B4C-15?wt%ZrO2 mixture (B15Z) achieved the maximum densification rate as twice much as that of pure B4C. The stress exponent n>3 indicated plastic deformation was the dominant densification mechanism of B15Z. The viscosities of plastic flow were evaluated using Murray-Rodger-William equation and the viscosity of B15Z was only a quarter of that in pure B4C. The sintering activation energy was calculated to be 305.9?kJ/mol for pure B4C and 197?kJ/mol for B15Z, respectively. It was proposed that the lower viscosity of plastic flow and activation energy accelerated the sliding and propagating motions of plastic flow, by which underlain the enhanced densification behaviors of B4C-ZrO2 mixtures. 相似文献
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Ying Chen HuiLi Zhang YuNing Liang YanHua Gao Yongchao Li 《Petroleum Science and Technology》2019,37(7):787-795
In this study, a simple hydrothermal synthesis method was adapted for the preparation of Co-doping Co2+/F-/TiO2 nanotubes photocatalyst, and the micro-nano structure of catalysts prepared by biomimetic technology which makes the catalyst have super-oleophilicity property. Co2+/F-/TiO2 revealed improved photocatalytic performance for denitrification of light oil compared to single TiO2 photocatalysts. The enhance of photocatalytic activity can be attributed to narrowing the band gap, increasing the light response wavelength and exposing more highly active crystal surfaces due to synergistic effects of Co2+ and F? in the photocatalyst. 相似文献
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