Gelatin‐carbohydrate phase‐separated hydrogels as bioactive carriers in vaginal delivery: Preparation and physical characterizations

The current study focuses on the alteration of properties of the gelatin hydrogels using polysaccharides (e.g., maltodextrin, dextran, and sodium carboxymethyl cellulose) for probable use in vaginal delivery of antimicrobials. The hydrogels were prepared by varying the proportions of gelatin and polysaccharides and were characterized by microscopy, mechanical testing, and impedance spectroscopy. Metronidazole (MZ), drug of choice for the treatment of bacterial vaginosis, was incorporated within the hydrogels. In vitro release studies of MZ from the hydrogels was studied in‐depth using modified Franz's diffusion cell. Antimicrobial efficiency of the MZ‐loaded hydrogels was tested against E. coli and B. subtilis. The results suggested that the incorporation of polysaccharides resulted in the phase‐separated hydrogels. The properties of the hydrogels was found be suitable for vaginal delivery. The drug release and antimicrobial efficiency from the hydrogels suggested that the developed hydrogels may be used for the delivery of antimicrobials in the vaginal lumen. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131, 40445.     

Palm oil‐based organogels and microemulsions for delivery of antimicrobial drugs

This study has been designed to develop palm oil (PO) based organogels using span 80/tween 80 mixture (OG) as a gelator system by fluid‐filled structure mechanism. The results suggested formation of organogels, emulsions, and microemulsions as the proportions of PO, OG and water were varied. The emulsions were found to be thermodynamically unstable as compared to the organogels and the microemulsions. Accelerated thermal stability test suggested that all the microemulsions and the organogels of only eight compositions were stable. The organogels showed viscoelastic property while the microemulsions showed viscous flow behavior. Both the organogels and the microemulsions were found to be highly hemocompatible and nonirritant. The antimicrobial efficiency of the ciprofloxacin HCl‐loaded formulations showed equivalent efficiency as compared to marketed formulations. The rates of drug release from the organogels were found to be relatively slower as compared to the microemulsions. The preliminary studies suggested that the developed organogel and microemulsion‐based formulations may be tried for topical delivery of antimicrobials. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2014 , 131, 39979.     

Conceptual Design of Unpressurized Shelters on Lunar Surface

Three concepts for the shelters on the moon are presented here. It is envisaged that the first robots will land on the moon and start preparing sites for advanced bases and also for future human presence. These robots will encounter severe radiation and micrometeor hits when they are exposed to the lunar atmosphere. During the period of intense solar radiation these robots have to be temporarily sheltered, since shielding on the robots may not be adequate to protect the instruments. The construction of these shelters has to be performed with very little equipment support. This paper presents concepts and their feasibility analysis for the fabrication of shelters under such stringent constraints.     

Realistic mobility simulation of urban mesh networks

It is a truism that today’s simulations of mobile wireless networks are not realistic. In realistic simulations of urban networks, the mobility of vehicles and pedestrians is greatly influenced by the environment (e.g., the location of buildings) as well as by interaction with other nodes. For example, on a congested street or sidewalk, nodes cannot travel at their desired speed. Furthermore, the location of streets, sidewalks, hallways, etc. restricts the position of nodes, and traffic lights impact the flow of nodes. And finally, people do not wander the simulated region at random, rather, their mobility depends on whether the person is at work, at lunch, etc. In this paper, realistic simulation of mobility for urban wireless networks is addressed. In contrast to most other mobility modeling efforts, most of the aspects of the presented mobility model and model parameters are derived from surveys from urban planning and traffic engineering research. The mobility model discussed here is part of the UDel Models, a suite of tools for realistic simulation of urban wireless networks. The UDel Models simulation tools are available online.     

Analysis of a Three-Phase Delta-Connected Inductive Load Controlled by an SCR-Diode Switch

A detailed analysis is presented of a system consisting of a three-phase delta-connected inductive static load controlled by a thyrode (SCR and diode) controller. The current equations are developed for a three-phase delta-connected inductive circuit representing the steady-state model of an induction motor. The simulated and actual current and voltage waveforms of an induction motor controlled by such an SCR-Diode controller are illustrated. The frequency/power spectra of the phase and line current are also presented.     

Product property and production rate control of styrene polymerization

A multivariable multi-rate nonlinear model predictive control (NMPC) strategy is applied to styrene polymerization. The NMPC algorithm incorporates a multi-rate Extended Kalman Filter (EKF) to handle state variable and parameter estimation. A fundamental model is developed for the styrene polymerization CSTR, and control of polymer properties such as number average molecular weight (NAMW) and polydispersity is considered. These properties characterize the final polymer distribution and are strong indicators of the polymer qualities of interest. Production rate control is also demonstrated. Temperature measurements are available frequently while laboratory measurements of concentration and molecular weight distribution are available infrequently with substantial time delays between sampling and analysis. Observability analysis of the augmented system provides guidelines for the design of the augmented disturbance model for use in estimation using the multi-rate EKF. The observability analysis links measurement sets and corresponding observable disturbance models, and shows that measurements of moments of the polymer distribution are essential for good estimation and control. The CSTR is operated at an open-loop unstable steady state. Control simulations are performed under conditions of plant-model structural mismatch and in the presence of parameter uncertainty and disturbances, and the proposed multi-rate NMPC algorithm is shown to provide superior performance compared to linear multi-rate and nonlinear single-rate MPC algorithms. The major contributions of this work are the development of the multi-rate estimator and the measurement design study based on the observability analysis.     

Immediate adaptation of the dog kidney to acute hypercapnia

Studies were performed to determine whether ammoniagenesis could adapt instantaneously to acidosis in the dog kidney. Following acute respiratory acidosis, renal glutamine extraction rose acutely in dogs with stable renal blood flow but did not change when the renal blood flow fell by more than 25%. Acute hypercapnia immediately increased renal ammonia production in both groups of dogs. The rate of both glutamine extraction and ammonia production in acutely hypercapnic dogs without hemodynamic changes was comparable to the rates observed in dogs with chronic metabolic acidosis. Furthermore, the renal metabolite profile observed in acute hypercapnia was similar to the pattern described in chronic metabolic acidosis, i.e., a marked fall in renal glutamate and alpha-ketoglutarate concentrations and a fivefold increase in malate and oxaloacetate concentrations. In the liver and muscle, acute hypercapnia induced no significant change in glutamine concentration but glutamate and alpha-ketoglutarate concentrations decreased. Our findings demonstrate that the dog kidney can adapt immediately to acidosis but that hemodynamic change may mask this adaptation.     

Water sorption and diffusion through saturated polyester and their nanocomposites synthesized from glycolyzed PET waste with varied composition

A new system of saturated polyester and their nanocomposites synthesized from glycolyzed PET with varied composition is investigated for the sorption and diffusion studies in water. The kinetics of sorption is studied by using the equation of transport phenomena. The values of ‘n’ from transport equation are found to be below ‘0.5’, showing the non-Fickian or pseudo-Fickian transport in the polymer. The dependence of diffusion coefficient on composition and temperature has been studied for all polymeric samples. The diffusion coefficient of saturated polyester samples decreases with an increase in glycolyzed PET contents. The nanocomposite samples show less diffusion coefficient than pristine polymer and it decreases with an increase in nano-filler up to 4 wt%. The diffusion coefficient increases with an increase in temperature for all the samples. The sorption coefficient shows a little change with variation in composition as well as temperature for all the samples and it is in a range of 1. The activation energy for diffusion and permeation is positive for all the samples. The heat of sorption is also positive for all the samples, indicating Henry type mode of sorption.