Experimental study on micro EDM-drilling of Ti6Al4V using helical electrode

There is a growing interest in the machining of micro-holes with high aspect-ratio in difficult-to-machine alloys for the aerospace industry. Processes based on electro discharge machining (EDM) and developed for the manufacture of both micro-electrode and micro-hole are actually used, but most of them involve micro-EDM machines. In this work, the influence of EDM parameters on material removal rate, electrode wear, machining time and micro-hole quality when machining Ti6Al4V is studied. Due to an inefficient removal of debris when increasing hole depth, a new strategy based on the use of helical-shaped electrodes has been proposed. The influence of helix angle and flute depth with respect to process performance has been addressed. Main results include 37% reduction in machining times (hole diameter 800 μm) when using electrode helix angle of 45° and flute-depth of 50 μm, and an additional 19% with flute-depth of 150 μm. Holes of 661 μm diameter and as much as 6.81 mm depth, which yields in aspect ratio of 10:1, have successfully been machined in Ti6Al4V.     

Small animal PET image super-resolution using Tikhonov and modified total variation regularisation

Positron emission tomography (PET) is an imaging procedure used mainly in the diagnosis and treatment of diseases. PET is also used in the preclinical research studies of small animals. However, researchers may have difficulty interpreting the particularly low-resolution images obtained via this procedure. This paper presents a new method of increasing the resolution of PET images through the use of super-resolution techniques. Aside from being resistant to the noise and other degradations that plague PET images, our proposed algorithm is also capable of preserving important structures (e.g. lesions). To this end, the proposed objective function includes a term based on the modified total variation model which allows the user to preserve texture and to deal with noise without incurring the artefacts that typically arise when the total variation norm is used. The present study shows the effectiveness of the method in recovering structures and details and indicates that, in most cases, it outperforms other state-of-the-art methods.     

A numerical model of the EDM process considering the effect of multiple discharges

The electrical discharge machining (EDM) process is, by far, the most popular amongst the non-conventional machining processes. The technology is optimum for accurate machining of complex geometries in hard materials, as those required in the tooling industry. However, although a large number of EDM machines are sold every year, scientific knowledge of the process is still limited. The complex nature of the process involves simultaneous interaction of thermal, mechanical, chemical and electrical phenomena, which makes process modelling very difficult. In this paper a new contribution to the simulation and modelling of the EDM process is presented. Temperature fields within the workpiece generated by the superposition of multiple discharges, as it happens during an actual EDM operation, are numerically calculated using a finite difference schema. The characteristics of the discharge for a given operation, namely energy transferred onto the workpiece, diameter of the discharge channel and material removal efficiency can be estimated using inverse identification from the results of the numerical model. The model has been validated through industrial EDM tests, showing that it can efficiently predict material removal rate and surface roughness with errors below 6%.     

Stabilization of nonlinear systems via forwarding mod{LgV}

Forwarding is a tool for constructing stabilizers for nonlinear systems. A key step in this design technique is to find an explicit solution to a partial differential equation (PDE), which may be hard to find (actually, the PDE may even not be solvable at all). In this paper we show that it is possible to provide an additional degree of freedom for the solution of the aforementioned PDE, hence effectively extending the realm of application of the forwarding methodology. Our contribution is illustrated with the example of an inverted pendulum with a disk inertia     

Generalized orderings of excess lifetimes of renewal processes

Several concepts of generalized orderings and generalized ageing classes have been considered in the literature (see Fagiuoli and Pellerey, 1993, Nav Res Logist 40: 829–842). They have been used in reliability, economics and actuarial sciences. These generalized notions provide a knowledge of the intrinsic structure of the ageing and ordering properties of random variables and have become an important tool in applied probability. In this paper, we provide new results about generalized orderings of excess lifetimes at different times of a renewal process when the underlying distribution belongs to some generalized ageing class. We also derive some interpretations and give some discussions of these results.     

‘Long autonomy or long delay?’ The importance of domain in opinion mining

Nowadays, people do not only navigate the web, but they also contribute contents to the Internet. Among other things, they write their thoughts and opinions in review sites, forums, social networks, blogs and other websites. These opinions constitute a valuable resource for businesses, governments and consumers. In the last years, some researchers have proposed opinion extraction systems, mostly domain-independent ones, to automatically extract structured representations of opinions contained in those texts. In this work, we tackle this task in a domain-oriented approach, defining a set of domain-specific resources which capture valuable knowledge about how people express opinions on a given domain. These resources are automatically induced from a set of annotated documents. Some experiments were carried out on three different domains (user-generated reviews of headphones, hotels and cars), comparing our approach to other state-of-the-art, domain-independent techniques. The results confirm the importance of the domain in order to build accurate opinion extraction systems. Some experiments on the influence of the dataset size and an example of aggregation and visualization of the extracted opinions are also shown.     

Intracellular Distributions of the Anthracycline 4′-iodo-4′-deoxy-Doxorubicin and Essential Trace Metals Using Nuclear Microprobe Analysis

The nuclear microprobe is an instrument of multi-elemental analysis with micro-imaging capabilities. Particle Induced X-ray Emission (PIXE) and Rutherford Backscattering Spectrometry (RBS) were performed simultaneously on cultured cancer cells exposed to an antitumor agent, the anthracycline 4′-iodo-4′-deoxy-doxorubicin (IDX). Element mapping revealed that iodine and iron spatial distributions were strongly correlated, suggesting iron intracellular chelation by the anthracycline. Iron and iodine co-localizations were generally observed within the nucleus region. Quantitative determination of trace element concentrations shown that the average amount of endogenous trace metals did not change in cells after two hours exposure to 20 μM IDX. It suggests that no extra-cellular iron was imported into the cells during IDX uptake. From these results, it can be concluded that iron-IDX complexes might be formed in the intracellular space, at least when IDX is administered at 20 μM, and could participate to the various biological effects of anthracyclines antitumor drugs.     

Characterisation of 4043 aluminium alloy deposits obtained by wire and arc additive manufacturing using a Cold Metal Transfer process

ABSTRACT

4043 aluminium deposits were elaborated using a 3D print device equipped with a Cold Metal Transfer welding source. Two sets of process parameters leading to different average powers were compared in order to establish the relations between the powers and energies produced and the geometrical characteristics of the deposits. The effects of the travel speed and layer superposition on the transfer mechanisms as well as on the geometrical characteristics of the deposits were discussed for both sets of parameters. Finally, the formed microstructures were analysed and the porosity defects were quantified and discussed with regard to the heat input characteristics and the solidification conditions.     

Catalytic Reduction of 4-Nitrobenzoic Acid by cis-[Rh(CO)2(Amine)2](PF6) Complexes Under Water–Gas Shift Reaction Conditions: Kinetics Study

Rhodium(I) complexes of the type, cis-[Rh(CO)₂(amine)₂](PF₆) where (amine = 3-picoline, 2-picoline, pyridine, 2,6-lutidina or 3,5-lutidine) dissolved in 80% aqueous amine solutions catalyzed the selective reduction of 4-nitrobenzoic acid to 4-aminobenzoic acid under CO atmosphere. The importance of these catalytic systems is their high chemo selectivity for the aromatic nitro group of the 4-nitrobenzoic acid with respect to the carboxylic group, allowing the production of the desired aromatic amine in high yields. The 4-aminobenzoic acid production depends on the nature of the coordinated amine. The Rh/3,5-lutidine system, the most active catalyst among tested, displays turnover frequencies for 4-aminobenzoic acid production of about 173 moles per mole Rh per day for [Rh] = 1 × 10^?4 mol, [4-nitrobenzoic acid] = 3.82 × 10^?3mol, 10 mL of 80% aqueous 3,5-lutidine, P(CO) = 0.9 atm at 100 °C. Analyses of kinetic results for the Rh/3,5-lutidine system show a first order dependence on 4-nitrobenzoic acid concentration, a non-linear dependence on CO pressure, a segmented Arrhenius plot and dependence on the nature of the reducing gas agent. These data are discussed in terms of a possible mechanism.