排序方式: 共有94条查询结果,搜索用时 15 毫秒
41.
Vinju?Vasudevan?Srinivasan Muthusamy?Poomalai?Pachamuthu Rajamanickam?MaheswariEmail author 《Journal of Porous Materials》2015,22(5):1187-1194
Lewis acidic mesoporous material (TUD-1) containing Fe was investigated as stable and reusable catalyst for the synthesis of Hantzsch 1,4-dihydropyridine (DHP) derivatives. Yields between 76 and 91 % of DHP derivatives were obtained in shorter reaction times of 3 h depending on the nature of substituents in benzaldehyde. 相似文献
42.
Hepatocyte‐Specific Delivery of siRNAs Conjugated to Novel Non‐nucleosidic Trivalent N‐Acetylgalactosamine Elicits Robust Gene Silencing in Vivo 下载免费PDF全文
Dr. Kallanthottathil G. Rajeev Dr. Jayaprakash K. Nair Dr. Muthusamy Jayaraman Dr. Klaus Charisse Nate Taneja Jonathan O'Shea Jennifer L. S. Willoughby Kristina Yucius Tuyen Nguyen Svetlana Shulga‐Morskaya Dr. Stuart Milstein Abigail Liebow Dr. William Querbes Dr. Anna Borodovsky Dr. Kevin Fitzgerald Dr. Martin A. Maier Dr. Muthiah Manoharan 《Chembiochem : a European journal of chemical biology》2015,16(6):903-908
We recently demonstrated that siRNAs conjugated to triantennary N‐acetylgalactosamine (GalNAc) induce robust RNAi‐mediated gene silencing in the liver, owing to uptake mediated by the asialoglycoprotein receptor (ASGPR). Novel monovalent GalNAc units, based on a non‐nucleosidic linker, were developed to yield simplified trivalent GalNAc‐conjugated oligonucleotides under solid‐phase synthesis conditions. Synthesis of oligonucleotide conjugates using monovalent GalNAc building blocks required fewer synthetic steps compared to the previously optimized triantennary GalNAc construct. The redesigned trivalent GalNAc ligand maintained optimal valency, spatial orientation, and distance between the sugar moieties for proper recognition by ASGPR. siRNA conjugates were synthesized by sequential covalent attachment of the trivalent GalNAc to the 3′‐end of the sense strand and resulted in a conjugate with in vitro and in vivo potency similar to that of the parent trivalent GalNAc conjugate design. 相似文献
43.
Suganthi Muthusamy Julie Charles B. Renganathan D. Sastikumar 《Journal of Materials Science》2018,53(22):15401-15417
Polypyrrole (PPy) and polypyrrole/Prussian blue (PPy–PB) nanocomposite-based fiber optic gas sensors are developed for gas sensing application. Prussian blue (PB) nanocubes are successfully grown on polypyrrole (PPy) nanoparticles by in situ oxidative polymerization method to obtain PPy–PB nanocomposite. PPy and PPy–PB are evaluated based on structural, morphological and electrical properties. The characteristic peaks present in the FTIR spectra of pure PPy and PB nanoparticles are also present in the FTIR spectrum of PPy–PB nanocomposite with small shifts in the absorption maximum. The XRD pattern reveals the semicrystalline structure of PPy–PB nanocomposite with an average crystallite size of 22 nm, and the morphology (FESEM) shows the formation of PB nanocubes over PPy matrix. AC conductivity measurements show slight improvement in the conductivity value of PPy–PB in comparison with PPy. Dielectric studies in the frequency range of 50 Hz–5 MHz reveal that PPy–PB nanocomposite is a high-k dielectric material. At 50 Hz, PPy–PB exhibits high dielectric constants of 1149 and 766 with low dielectric loss values of 9.9 and 4.6 at 150 and 120 °C, respectively. Further, their application as fiber optic gas sensors in sensing various gases is studied using fiber optic technique. The spectral response is studied for various concentrations (0–500 ppm) of ammonia, acetone and ethanol gases at room temperature. The study shows that the spectral intensity increases linearly with different concentrations of all gases. The clad-modified fiber optic sensor with PPy–PB nanocomposite exhibits enhanced sensitivity for ethanol than clad-modified fiber optic sensor with PPy nanoparticles. TGA studies reveal the high thermal stability of PPy–PB nanocomposite. Hence, PPy–PB-based fiber optic sensors can be used to sense toxic ethanol vapor not only at room temperature but also in a composite environment where a temperature variation is expected. 相似文献
44.
Masilamani Muruganandam Muthusamy Madheswaran 《International Journal of Control, Automation and Systems》2013,11(5):966-975
The attempt is made to enhance the performance of a closed loop control of DC series motor fed by DC chopper (DC-DC buck converter) by hybridization of PID controller with an intelligent control using ANN (Artificial Neural Network) controller. This system consists of inner current controller loop and outer PID-ANN based speed controller loop. The current controller allows the PWM (Pulse Width Modulation) signal when the motor current is less than set value. The PID-ANN speed controller controls the motor voltage by controlling the duty cycle of the chopper thereby the motor speed is regulated. The PID-ANN controller performances are analyzed in both steady state and dynamic operating condition with various set speed and various load torque. The rise time, maximum over shoot, settling time, steady state error and speed drops are taken for comparison with conventional PID controller and existing work. The steady state stability analysis of the system also is made by using the transfer function model with MATLAB. The training data for PID-ANN controller is taken from conventional PID controller. The Hybrid PID-ANN controller with DC chopper has better control over the conventional PID controller and the reported existing work. This system is simulated using MATLAB/Simulink and also it is implemented with a NXP 80C51 family Microcontroller (P89V51RD2 BN) based Embedded System. 相似文献
45.
In this work, new water-soluble polypyrrole–sulfonated melamine formaldehyde nanocomposites (PPy–SMF NCs) were first synthesized by one-step in-situ polymerization of pyrrole with FeCl3 in the presence of various mole ratios of sulfonated melamine formaldehyde (SMF). The characterization of the PPy–SMF NCs was investigated via ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray, dynamic light scattering, transmission electron microscopy, X-ray diffraction, thermogravimetric analysis, differential scanning calorimetry, and conductivity measurements. The resulting PPy–SMF NCs were proved to improve the solubility, electrical properties, and thermal stability. The anti-corrosion performance of PPy-SMF NCs on 316 L stainless steel (316 L SS) was examined using electrochemical impedance spectroscopy, potentiodynamic polarization, and weight-loss method. The result showed that the PPy–SMF NCs acts as a mixed-type inhibitor, as well as a protective layer to 316 L SS against corrosion in 3.5% NaCl solution. The Langmuir adsorption isotherm was well fitted and suitable to explain the adsorption behavior of the PPy-SMF NCs on 316 L SS surface. The inhibition efficiency of PPy-SMF NCs is 99% by the weight-loss method which could be attributed to the protective layer formed on 316 L SS surface by the adsorption of PPy-SMF NCs. 相似文献
46.
Boopathi Muthusamy Sujatha Ramalingam Senthil Kumar Chandran Sathish Kumar Kannaiyan 《IET nanobiotechnology / IET》2021,15(2):173
Herein, multivariate Lagrange''s interpolation polynomial (MLIP) and multivariate least square (MLS) methods are used to derive linear and higher‐order polynomials for two varied applications. (1) For an effective fabrication of Pectin degrading Fe3O4‐SiO2 Nanobiocatalyst activity (IU/mg). Here, the three parameters namely: pH value, pectinase loading and temperature as independent variables are optimized for the maximal of anobiocatalyst activity as a dependent variable. (2) For a passive system reliability estimation of decay heat removal (DHR) of a nuclear power plant. The success criteria of the system depend on three types temperature that do not exceed their respective design safety limits and are considered as dependent variables and 14 significant parameters were used as independent variables. Statistically, the validation of these multivariate polynomials are done by testing of hypothesis. Comparative study of the proposed approach gives significance results in the first application have the optimum conditions for maximum activity using linear MLIP method is: 58.64 with pH = 4, pL = 250 and Temp = 4°C. The maximum activity using second order MLIP method is 59.825 and method of MLS is 59.8249 with the optimized values of an independent variables pH = 4, pL = 300 and Temp = 8°C depicted in Table 1. In DHR system, the significance results are obtained and depicted in Table 2. 相似文献
47.
ABSTRACTIn this work, the moisture management properties of combination herbal extract treated cotton knitted fabrics were explored. The herbs namely wild turmeric (Curcuma aromatica Salisb.) and holy basil (Ocimum tenuiflorum L.) were used for the study. The pre-treated single jersey cotton knitted fabrics were given finishing treatment with 50%:50% combination herbal extract of wild turmeric and holy basil using pad-dry-cure method. The randomized response surface Box–Behnken design using quadratic model was used for the finishing treatment with process parameters such as combination herbal extract concentration of 1%, 2.5%, and 4%; crosslinking agent concentration of 3%, 5%, and 7%; curing temperature of 80°, 100°, and 120°. The analysis of variance results analysis using Design Expert software shows that the moisture management properties of the treated fabrics are influenced by the finishing process parameters. The study results revealed that the finishing treatment has altered the moisture management properties of the treated fabrics and resulted in excellent accumulative one way transport capability which increased their overall moisture management capability. 相似文献
48.
In this research work, aluminium oxide/yttria stabilized zirconia (20%Al2O3/80%8YSZ) and ceria/yttria stabilized zirconia (20%CeO2/80%8YSZ) were coated through atmospheric plasma spray technique (APS) as thermal barrier coating (TBC) over CoNiCrAlY bond coat on aluminium alloy (Al-13%Si) substrate piston crown material and their thermal cycling behavior were studied experimentally. Thermal cycle test of both samples were conducted at 800?°C. Microstructural, phase and elemental analysis of the TBC coatings were experimentally investigated. The performance, combustion and emission characteristics of Al2O3/8YSZ, CeO2/8YSZ TBC coated and uncoated standard diesel engine were experimentally investigated. The test results revealed that CeO2/8YSZ based TBC has an excellent thermal cycling behavior in comparison to the Al2O3/8YSZ based TBC. The spallation of the Al2O3/8YSZ TBC occurred mainly due to the formation of thermally grown oxide (TGO), and growth of residual stresses at top coating and bond coating interface. The experimental results also revealed that the increase of brake thermal efficiency and reduction of specific fuel consumption for both TBC coated engine. Further reduction of HC, CO and smoke and increase of NOx emission were recorded for both TBC coated engine compared to the standard diesel engine. 相似文献
49.
Lebeau B Brendlé J Marichal C Patil AJ Muthusamy E Mann S 《Journal of nanoscience and nanotechnology》2006,6(2):352-359
A room-temperature sol-gel-based process was used to produce by direct synthesis talc-like organosilicates having hexadecyl or aminopropyl groups pending in the interlayer space. Thermal analyses, Fourier transform infrared and 13C/29Si solid-state nuclear magnetic resonance spectroscopies confirmed the presence of organic moieties bonded to the inorganic network. Exfoliation of these organoclays in polar solvents such as water for the positively charged magnesium phyllo(aminopropyl)silicate, and in low polar solvents such as toluene and chloroform for hydrophobic magnesium phyllo(hexadecyl)silicate, was investigated by TEM. The ability of these layered magnesium organosilicates to exfoliate in appropriate solvents was exploited for the preparation of transparent self-supporting films and ordered macroporous networks using by latex colloidal crystal templates. 相似文献
50.