基于补偿模糊神经网络的智能诊断系统

提出了一种基于补偿模糊神经网络的智能诊断系统,该系统将神经网络和补偿模糊逻辑相结合,采用动态、全局优化的运算,充分利用了相互间的优点.在神经网络的学习算法中,动态优化补偿模糊运算,使网络更适用、更优化.网络不仅能适当调整输入输出模糊隶属函数,也能借助于补偿逻辑算法动态优化相应的模糊推理,由于补偿模糊逻辑神经网络引入了补偿模糊神经元,能使网络从初始定义的模糊规则开始训练,使网络容错率更高,系统更稳定.仿真实验证明该模型在智能诊断中具有收敛速度快,诊断精度高,而且适应性强等优点.     

探索提高三维定量构效关系模型预测能力的方法

为了解决使用三维定量构效关系(three-dimensional quantitative structure-activity relationship,3D-QSAR)模型预测新化合物生物活性效果不理想的问题,建立了2种新的一致性模型.模型一是由多元线性回归(multiple linear regression,MLR)方法构建的加权一致性模型(weighted consensus modeling,WCM),该模型为每个子模型添加了各自的权重系数.模型二通过计算多个子模型预测值的平均值来构建平均一致性模型(average consensus modeling,ACM).研究结果表明,当交叉验证相关系数0.5q~2≤0.8时,一致性模型可以提高预测能力,而在q~20.8时不能提高3D-QSAR模型的预测能力.该方法可为提高模型预测能力和设计新型高活性抑制剂提供帮助.     

第三章研究与发展现状

文章介绍了当前在无线通信技术领域国外的相关研究计划,它们的技术特征和应用范围,介绍了现有的几种基于无线技术的原型产品.     

Significant Enhancement of Photothermal and Photoacoustic Efficiencies for Semiconducting Polymer Nanoparticles through Simply Molecular Engineering

Semiconducting polymer nanoparticles (SP NPs) are employed as efficient nanoagents for “all‐in‐one” theranostic nanoplatforms with dual photoacoustic imaging (PAI) and photothermal therapy (PTT) functions based on their photothermal conversion effect. However, the mechanisms of tuning the PTT efficiency are still elusive, though several SP NPs with high photothermal efficiency are reported. Herein, two donor–acceptor (D–A) SP NPs PTIGSVS and PIIGSVS with the same donor unit but different acceptor units are designed and synthesized. Through tuning the acceptor unit, PTIGSVS shows more planar backbone structure, stronger D–A strength, redshifted absorption, enhanced extinction efficient, weakened emission properties, and more efficient nonradiative decay in comparison to the polymeric analogue PIIGSVS . Thus, PTIGSVS NPs present much higher photothermal conversion efficiencies (74%) than PIIGSVS NPs (11%), resulting in significantly enhanced in vitro and in vivo PAI and PTT performance. This contribution demonstrates that PTIGSVS NPs are superior PA/PTT agents for effective cancer theranostic and shed light on understanding the relationship between molecular structures and photothermal effect of CPs.     

ID-based proxy re-signature without pairing

Several new attacks have been identified in CRNs such as primary user emulation, dynamic spectrum access (DSA), and jamming attacks. Such types of attacks can severely impact network performance, specially in terms of the over all achieved network throughput. In response to that, intrusion detection system (IDS) based on anomaly and signature detection is recognized as an effective candidate solution to handle and mitigate these types of attacks. In this paper, we present an intrusion detection system for CRNs (CR-IDS) using the anomaly-based detection (ABD) approach. The proposed ABD algorithm provides the ability to effectively detect the different types of CRNs security attacks. CR-IDS contains different cooperative components to accomplish its desired functionalities which are monitoring, feature generation and selection, rule generation, rule based system, detection module, action module, impact analysis and learning module. Our simulation results show that CR-IDS can detect DSA attacks with high detection rate and very low false negative and false positive probabilities.     

胞内分枝杆菌HSP 70基因的克隆、分析及原核表达

胞内分枝杆菌为致病性非结核分枝杆菌（NTM）之一,分布广泛,人畜均可感染,对人畜健康造成极大威胁。应用巢式PCR克隆胞内分枝杆菌HSP 70基因,利用在线分析软件对其进行生物信息学分析。构建原核表达载体p ET15b-HSP 70,同时进行诱导表达。结果显示,胞内分枝杆菌HSP 70基因完整,ORF基因全长1860bp,共编码619个氨基酸,HSP 70为酸性、亲水性蛋白质,不存在明显跨膜结构,含14个潜在磷酸化位点,亚细胞定位主要存在于细胞质中,无信号肽结构。二级结构预测,蛋白空间结构以α-螺旋和无规则卷曲为主。同时,以同源建模法预测了HSP 70基因编码蛋白的三维立体结构。成功构建p ET 15b-HSP 70原核表达载体,在原核表达系统中该载体可诱导表达70ku的HSP70重组蛋白。     

亚稳态Bi2SiO5晶体的制备及析晶热力学分析

采用熔体冷却法制备了亚稳态Bi2SiO5硅酸铋晶体,利用XRD、SEM等表征分析了所制备Bi2SiO5多晶的晶型及形貌特征.通过系统在相平衡温度时的可逆相变过程,计算了析晶过程的ΔH、ΔS和ΔG.实验结果表明:组成中当摩尔比Bi2O3/SiO2为1∶1时,所生成的Bi2SiO5晶体在2h保温时间后仍没有发生晶型转变.所制备的单相Bi2SiO5晶粒呈现层状生长,且层与层之间呈现紧密生长.热力学分析表明:当温度T=T0-ΔT=973.15K时,ΔG=-7.478KJ<0,说明从基础熔体中析出Bi2SiO5的过程是自发进行的;同时,熔体中的分相有利于Bi2SiO5晶体的析出.     

隔振机械结构振动响应工程预报方法

在估计隔振机械结构振动传递特性和振动响应过程中,目前的方法都需要已知激励力或激励源的输入阻抗,这对实际工程中大型机械设备来说是很困难的.可以通过将隔振系统输入输出端频响函数相除的方法消去激励力,利用隔振机械结构输入输出端的振动响应估计出振动传递特性,用比例函数来表示,再用不同时刻或不同工况下结构输入端振动响应的监测结果,对结构输出端的振动响应进行预报和监测.研究表明,这种方法适用于单激励源和多源非耦合激励源情况下的振动响应预报,实验结果验证了估计方法的有效性.     

中国地震灾害损失评估模型与实证分析研究

中国是世界上地震灾害多发的国家之一,对强震灾害损失进行准确的评价研究具有重要的经济和社会意义。文章着重对震灾的经济损失方面进行评估,将其分为直接经济损失和间接经济损失2个部分。首先运用K-S检验确定我国年地震损失额的分布函数,并对月地震次数进行拟合,然后运用灰色聚类法和主成分分析法对不同震灾分别进行直接和间接经济损失评级,最后对2006-2009年我国地震所造成的经济损失进行评估,对8次震灾进行综合经济损失评级。     

地震可控震源非线性扫描应用初探

非线性扫描是用于可控震源地震勘探的一项新技术。它能控制输入信号的频谱,因而可用来提高输入信号的高频成份,补偿地层的衰减,提高地层分辨力;也可用来压制某一频率的规则干扰波(如面波、低频干扰)等。这对地层吸收大,低频干扰严重的地区的资料采集工作,特别是对于浅层高频地震勘探有着十分重要的意义。本文着重介绍我们在贵州南部碳酸盐岩地区的非线性扫描初步试验结果。