Photoconductive optically driven deformable membrane for spatial light modulator applications utilizing GaAs substrates

The fabrication and characterization of an optically addressable deformable mirror for a spatial light modulator is described. Device operation utilizes an electrostatically driven pixellated aluminized polymeric membrane mirror supported above an optically controlled photoconductive GaAs substrate. A 5 microm thick grid of patterned photoresist supports the 2 microm thick aluminized Mylar membrane. A conductive ZnO layer is placed on the back side of the GaAs wafer. A standard Michelson interferometer is used to measure mirror deformation data as a function of illumination, applied voltage, and frequency. A simplified analysis of device operation is also presented.     

Real-time holographic deconvolution techniques for one-way image transmission through an aberrating medium: characterization, modeling, and measurements

We propose and demonstrate a new photorefractive real-time holographic deconvolution technique for adaptive one-way image transmission through aberrating media by means of four-wave mixing. In contrast with earlier methods, which typically required various codings of the exact phase or two-way image transmission for correcting phase distortion, our technique relies on one-way image transmission through the use of exact phase information. Our technique can simultaneously correct both amplitude and phase distortions. We include several forms of image degradation, various test cases, and experimental results. We characterize the performance as a function of the input beam ratios for four metrics: signal-to-noise ratio, normalized root-mean-square error, edge restoration, and peak-to-total energy ratio. In our characterization we use false-color graphic images to display the best beam-intensity ratio two-dimensional region(s) for each of these metrics. Test cases are simulated at the optimal values of the beam-intensity ratios. We demonstrate our results through both experiment and computer simulation.     

Volume computed tomography air kerma index and image quality evaluation in Brazil

The aim of this study was to evaluate the image quality of 29 computed tomography (CT) scanners in Brazil and to perform estimations of patient dose and image quality of common CT examinations at these equipment. The volume CT air kerma indexes (C(VOL)) were estimated, using normalised weighted air kerma indexes, supplied by the ImPACT group. The image quality tests were performed using the phantom and accreditation protocol from the American College of Radiology (ACR). The C(VOL) values for head scans varied between 8.7 and 108 mGy. The Hi-res chest examinations presented C(VOL) values varying from 0.4 to 32 mGy. For abdominal scans, the estimated C(VOL) values varied between 4.1 and 94 mGy. This wide variation of air kerma between different centres is related to the scanner type and also to the scanning parameters. The results also showed that the image quality did not attend all ACR CT accreditation requirements.     

Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging

Understanding the control of the optical and plasmonic properties of unique nanosystems--gold nanostars--both experimentally and theoretically permits superior design and fabrication for biomedical applications. Here, we present a new, surfactant-free synthesis method of biocompatible gold nanostars with adjustable geometry such that the plasmon band can be tuned into the near-infrared region 'tissue diagnostic window', which is most suitable for in vivo imaging. Theoretical modelling was performed for multiple-branched 3D nanostars and yielded absorption spectra in good agreement with experimental results. The plasmon band shift was attributed to variations in branch aspect ratio, and the plasmon band intensifies with increasing branch number, branch length, and overall star size. Nanostars showed an extremely strong two-photon photoluminescence (TPL) process. The TPL imaging of wheat-germ agglutinin (WGA) functionalized nanostars on BT549 breast cancer cells and of PEGylated nanostars circulating in the vasculature, examined through a dorsal window chamber in vivo in laboratory mouse studies, demonstrated that gold nanostars can serve as an efficient contrast agent for biological imaging applications.     

Time‐dependent shape functions for modeling highly transient geothermal systems

This paper presents new time‐dependent finite element shape functions suitable for modeling high‐gradient transient conductive heat flow in geothermal systems. The shape functions are made adaptive by enhancing the approximation functions with time‐dependent variables, which may vary according to the transient process without adding extra degrees of freedom or applying mesh adaptation. Two different approaches are presented. First, an iterative method is proposed, in which an exponential approximation function, which is optimized continually during the transient process, is incorporated in the shape function. Second, an analytical method is suggested, in which an analytical solution of a simplified process is incorporated in the shape function, enabling an explicit update of the shape functions in each time step. A methodology for modeling the variation of temperature in one and two dimensions is introduced. The ability of the method to capture high‐gradient temperature profiles using relatively large elements is illustrated with numerical examples of cases in which equally large standard finite elements fail. Copyright © 2008 John Wiley & Sons, Ltd.     

Optimal Water Resources Management: Case of Lower Litani River, Lebanon

The pressures of human population and patterns of development frequently jeopardize the integrity of river systems worldwide. An integrated approach to water resources management is essential, particularly in developing countries. This study presents the results of the water resources optimization conducted for the Lower Litani River Basin in Lebanon. The overall aim of the project is to develop, test, and critically evaluate an innovative approach to water resources management in the Mediterranean region. The method explores the ways in which multiple environmental, economic, and social benefits can be achieved through integrated management of water resources. The Water Resources Model was utilized to assess the efficiency of the baseline model scenario and for the optimization process of the different scenarios of the Litani Lower Basin. Strengths, weaknesses, opportunities and threats analysis was applied in order to derive the objectives and constraints. Results revealed that the potential retained scenarios aim at decreasing water consumption and demand, losses, and return flow. These scenarios mainly include the shift to drip irrigation, awareness campaigns, and losses control in domestic supply pipes. Other retained scenarios having a higher shortfall rely on the use of the Channel concrete lining to decrease losses and return flow, in addition to the awareness campaigns in both domestic and irrigation sectors, and less consumptive/more efficient irrigation methods such as sprinkler and drip irrigation at variable application percentages. Hence, most of the interventions or measures proposed are generally not costly and can be implemented.     

Resilient modulus–moisture content relationships for pavement engineering applications

In recent years, there has been an increased interest in determining the influence of moisture changes on the resilient modulus (M_R) of subgrade soils beneath pavement structures. Efforts have also been made to develop mathematical models that predict the change in M_R values with moisture. These models are expected to account for seasonal variations in subgrade moisture content. This study evaluates the variation of resilient modulus with post-compaction moisture content of soils in the State of Oklahoma and the State of Pennsylvania. A series of specimens was compacted at optimum moisture content and then tested for resilient modulus; other series of specimens were prepared at optimum moisture content and then either wetted or dried prior to M_R testing. Employed wetting and drying procedures are time-efficient in developing the M_R–moisture relationships. Results showed that M_R–moisture content relationships varied with soil types and M_R values varied inversely with changes of moisture content. In addition, an M_R–moisture model predicting the variation of resilient modulus with moisture contents is proposed. This model can be used to predict changes in the bearing capacity of pavements due to seasonal variations of moisture content.     

Urodynamic correlates of resolution of reflux in meningomyelocele patients

PURPOSE: Resolution of reflux in meningomyelocele patients is a reflection of improved bladder storage. We correlated resolution of reflux with changes observed in sequential urodynamic studies. MATERIALS AND METHODS: The study included 27 children with meningomyelocele born between 1975 and 1985 who presented with or developed vesicoureteral reflux. Resolution of reflux was observed during the 10-year followup period as they were treated with a regimen of clean intermittent catheterization and pharmaco-therapy. Urodynamic studies were performed when vesicoureteral reflux was present and subsequent to its resolution. The urodynamic parameters compared in the 2 studies included bladder capacity, pressure specific bladder volume, bladder compliance and leak point pressure. RESULTS: Significant increases in bladder capacity, pressure specific bladder volume and bladder compliance were noted. Leak point pressure appeared to be decreased subsequent to resolution of reflux. CONCLUSIONS: Resolution of reflux in meningomyelocele patients correlates with changes in parameters of bladder storage observed on sequential urodynamic studies.     

Comparison of 6-s-cis- and 6-s-trans-locked analogs of 1alpha,25-dihydroxyvitamin D3 indicates that the 6-s-cis conformation is preferred for rapid nongenomic biological responses and that neither 6-s-cis- nor 6-s-trans-locked analogs are preferred for genomic biological responses

The hormone 1alpha,25-dihydroxyvitamin D3 [1alpha,25(OH)2D3] generates biological responses via both genomic and rapid, nongenomic mechanisms. The genomic responses utilize signal transduction pathways linked to a nuclear receptor (VDRnuc) for 1alpha,25(OH)2D3, while the rapid responses are believed to utilize other signal transduction pathways that may be linked to a putative membrane receptor for 1alpha,25(OH)2D3. The natural seco steroid is capable of facile rotation about its 6,7 single carbon bond, which permits generation of a continuum of potential ligand shapes extending from the 6-s-cis (steroid like) to the 6-s-trans (extended). To identify the shape of conformer(s) that can serve as agonists for the genomic and rapid biological responses, we measured multiple known agonist activities of two families of chemically synthesized analogs that were either locked in the 6-s-cis (6C) or 6-s-trans (6T) conformation. We found that 6T locked analogs were inactive or significantly less active than 1alpha,25(OH)2D3 in both rapid responses (transcaltachia in perfused chick intestine, 45Ca2+ influx in ROS 17/2.8 cells) and genomic (osteocalcin induction in MG-63 cells, differentiation of HL-60 cells, growth arrest of MCF-7 cells, promoter transfection in COS-7 cells) assays. In genomic assays, 6C locked analogs bound poorly to the VDRnuc and were significantly less effective than 1alpha,25(OH)2D3 in the same series of assays designed to measure genomic responses. In contrast, the 6C locked analogs were potent agonists of both rapid response pathways and had activities equivalent to the conformationally flexibile 1alpha,25(OH)2D3; this represents the first demonstration that 6-s-cis locked analogs can function as agonists for vitamin D responses.